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In all disease processes, different aspects are stressed by the microbiologist, biochemist, geneticist, statistician, clinician, etc. But it is the . Use is made of different tools to come to some conclusion as to the nature and cause of lesions.

Atheroma lesions have a spectrum of changes. Small localized raised foci in the young progress over years to form large areas of gruel and then go on to calcify and fibrose.

Let us press on to the findings of the study. Reexamination of the pathological features, with due consideration for the presence of organisms, opened up new insights into the lesion.

If there was no resistance, attack by germs would continue unabated until complete destruction of the artery occurred. Luckily, the body has some defense mechanisms to counteract foreign invaders. Different cellular, inflammatory, and immunological mechanisms come into play in reaction to invasion and damage by germs.

The next stage occurs when the fatty streak lesion progresses to form a mass of necrotic atheroma gruel, the so-called fibronecrotic plaque.

Let us look at the lesion in another manner. Scanning electron micrographs do not show the fine detail one sees with transmission electron micrographs, but they do show the scene in three dimensions and are probably more easily related to the world we know.

There are molecular biological studies confirming that plays some role in the lesion. Studies are unraveling various mechanisms in which plays a role in the inflammatory processes, lymphocytic infiltrate, muscle damage, macrophage infiltrate, and other aspects that make up part and parcel of the atheroma lesion []–[].

Lipid has dominated research in the field of atherogenesis—so much so that it has come to be regarded as the sine qua non of atherosclerosis.

Based on pathological features, the evidence points to the existence of a arterial lesion. The question, however, is whether atherosclerosis lesions are all one and the same, or different lesions, with some being related.

The first aspect that needs attention, if we are to start treatment of atheroma lesions per se, is development of some method of diagnosis.