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Alzheimer's and Dementia: The Journal of the Alzheimer's Association

Resumen/Descripción – provisto por la editorial en inglés
The mission of Alzheimer's & Dementia: Journal of the Alzheimer's Association is to bridge the knowledge gaps across a wide range of bench-to-bedside investigation. The journal publishes the results of studies in: behavior, biochemistry, genetics, molecular biology, pharmacology, physiology, protein chemistry, neurology, neuropathology, psychiatry, geriatrics, neuropsychology, epidemiology, sociology, health services research, health economics, political science and public policy. Content emphasizes interdisciplinary investigations, integrative/translational articles, related to: etiology, risk factors, early detection, disease modifying interventions, prevention of dementia and applications of new technologies in health services. The journal publishes • comprehensive reviews; • research articles; • information on clinical trials; • short reports;
• in-depth perspectives/open-peer commentaries; • theoretical and/or translational papers that attempt integrate knowledge across discipline;
• history & politics of science/brief biographies and, • abstracts of papers presented at international meetings. Negative results, particularly clinical trials, are published as short communications.

The ultimate objective is to create a novel forum for: • rapid communication of new findings, ideas or perspectives; • disseminating knowledge, across the spectrum of basic to clinical studies, necessary for optimal translation of research findings into practical applications/interventions; • integrating knowledge across disciplines; • increase knowledge in diverse disciplines to promote early detection/diagnosis and/or interventions; • formulating new theories and/or strategies for the rigorous testing of theories or their predictions; • identifying promising new directions of research and, • providing the scientific impetus for new initiatives; or public policies concerning research on prevention and new models of health services.

Alzheimer's & Dementia is indexed/abstracted in Index Medicus/MEDLINE, Scopus, Science Citation Index Expanded (SciSearch®), Current Contents®/Clinical Medicine, Neuroscience Citation Index®, and Journal Citation Reports/Science Edition.
Palabras clave – provistas por la editorial

No disponibles.

Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde ene. 2005 / hasta dic. 2023 Wiley Online Library

Información

Tipo de recurso:

revistas

ISSN impreso

1552-5260

ISSN electrónico

1552-5279

Editor responsable

Elsevier

País de edición

Países Bajos

Fecha de publicación

Tabla de contenidos

The Nairobi Declaration—Reducing the burden of dementia in low‐ and middle‐income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs

Gladys Maestre; Maria Carrillo; Raj Kalaria; Daisy Acosta; Larry Adams; Thierry Adoukonou; Kazeem Akinwande; Joshua Akinyemi; Rufus Akinyemi; Onoja Akpa; Suvarna Alladi; Ricardo Allegri; Raul Arizaga; Faheem Arshad; Oyedunni Arulogun; David Babalola; Olusegun Baiyewu; Thomas Bak; Tarek Bellaj; Judith Boshe; Carol Brayne; David Brodie‐Mends; Richard Brown; Jennifer Cahn; Nkouonlack Cyrille; Albertino Damasceno; Ranil de Silva; Rohan de Silva; Mamuka Djibuti; Anna Jane Dreyer; Ratnavalli Ellajosyula; Temitope Farombi; Bernard Fongang; Stefania Forner; Rob Friedland; Noe Garza; Antoine Gbessemehlan; Eliza (Eleni‐ Zacharoula) Georgiou; Riadh Gouider; Ishtar Govia; Lea Grinberg; Maëlenn Guerchet; Seid Gugssa; Joy Louise Gumikiriza‐Onoria; Deborah Gustafson; Eef Hogervorst; Michael Hornberger; Agustin Ibanez; Masafumi Ihara; Ozama Ismail; Thomas Issac; Linus Jönsson; Celestin Kaputu; Wambui Karanja; Jackline Karungi; Desire Tshala‐Katumbay; Brian Kunkle; Joseph H Lee; Iracema Leroi; Raphaella Lewis; Gill Livingston; Francisco Lopera; Kamada Lwere; Facundo Manes; Lingani Mbakile‐Mahlanza; Pedro Mena; Bruce Miller; Athanase Millogo; Abdul Mohamed; Christine Musyimi; Victoria Mutiso; Noeline Nakasujja; David Ndetei; Sam Nightingale; Alfred K. Njamnshi; Gabriela Novotni; Primrose Nyamayaro; Solomon Nyame; Julius Ogeng'o; Adesola Ogunniyi; Maira Okada De Oliveira; Njideka Okubadejo; Martin Orrell; Akintunde Orunmuyi; Mayowa Owolabi; Stella Paddick; Margaret A Pericak‐Vance; Zvezdan Pirtosek; Felix Potocnik; Bill Preston; Rema Raman; Kirti Ranchod; Mie Rizig; Monica Rosselli; Roy Deepa; Upal Roy; Marufjon Salokhiddinov; Mary Sano; Fred Sarfo; Claudia L Satizabal; Diego Sepulveda‐Falla; Sudha Seshadri; Claire Sexton; Ingmar Skoog; Peter St George‐Hyslop; Claudia Suemoto; Jeremy Tanner; Prekshya Thapa; Kamadore Toure; Valentine Ucheagwu; Chinedu Udeh‐Momoh; Victor Valcour; Jeffery Vance; Mathew Varghese; Jaime Vera; Richard Walker; Wendy Weidner; Walsh Sebastian; Patrice Whitehead Gay; Henrik Zetterberg; Yared Zewde;

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. 1105-1108

Dissipating the fog: Cognitive trajectories and risk factors 1 year after COVID‐19 hospitalization

Natalia Gomes Gonçalves; Márlon Juliano Romero Aliberti; Laiss Bertola; Thiago Avelino‐Silva; Murilo Bacchini Dias; Daniel Apolinario; Geraldo Busatto; Orestes Forlenza; Ricardo Nitrini; Sonia Maria Dozzi Brucki; Andre Russowsky Brunoni; Kallene Summer Moreira Vidal; Wilson Jacob‐Filho; Claudia Kimie Suemoto;

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. No disponible

Vitamin D intake and cognitive decline in Blacks and Whites: The role of diet and supplements

Klodian Dhana; Lisa L. Barnes; Puja Agarwal; Xiaoran Liu; Anisa Dhana; Pankaja Desai; Neelum Aggarwal; Denis A. Evans; Kumar B. Rajan

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. 1135-1142

Cost effectiveness of non‐drug interventions that reduce nursing home admissions for people living with dementia

Eric Jutkowitz; Laura T. Pizzi; Peter Shewmaker; Fernando Alarid‐Escudero; Gary Epstein‐Lubow; Katherine M. Prioli; Joseph E. Gaugler; Laura N. Gitlin

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. No disponible

Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm‐FINGERS): Study design and harmonization

Lucia Crivelli; Ismael Luis Calandri; Claudia Kimie Suemoto; Rosa María Salinas; Lina Marcela Velilla; Mônica Sanches Yassuda; Paulo Caramelli; Francisco Lopera; Ricardo Nitrini; Gustavo Emilio Sevlever; Ana Luisa Sosa; Daisy Acosta; Ana María Charamelo Baietti; María Isabel Cusicanqui; Nilton Custodio; Sergio Dansilio De Simone; Carolina Delgado Derio; Lissette Duque‐Peñailillo; Juan Carlos Duran; Ivonne Z. Jiménez‐Velázquez; Jorge Mario Leon‐Salas; Yanina Bergamo; María Florencia Clarens; Andrés Damian; Ignacio Demey; María Belén Helou; Carlos Márquez; María Eugenia Martin; Maria da Graça Morais Martin; Diego Querze; Ezequiel Ignacio Surace; Sabrina Acosta‐Egea; Esteban Aguirre–Salvador; Leonardo Cruz de Souza; Gustavo Henrique da Cunha Peixoto Cançado; Sonia Maria Dozzi Brucki; Clarisse Vasconcelos Friedlaender; Karina Braga Gomes; Myriam Gutierrez; Carlos Laforcada Ríos; Joyce Graciela Martinez Galindo; Rosa Montesinos; Alberto Nuñez‐Herrera; Sebastián Ospina‐Henao; Guillermina Rodríguez; Victoria Ruiz Masson; Mónica Sánchez; Christian E. Schenk; Ligia Soto; Maira Tonidandel Barbosa; Jéssica Abdo Gonçalves Tosatti; Yosselin Vicuña; Mark Espeland; Krister Hakansson; Miia Kivipelto; Laura Baker; Heather Snyder; María Carrillo; Ricardo Francisco Allegri

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. No disponible

Demographically‐adjusted normative data among Latinos for the version 3 of the Alzheimer's Disease Centers’ Neuropsychological Test Battery in the Uniform Data Set

María J. Marquine; Adam Parks; Jaime Perales‐Puchalt; David A. González; Mónica Rosado‐Bruno; Rebecca North; Carl Pieper; Amy E. Werry; Andrew Kiselica; Silvia Chapman; Hiroko Dodge; Kathryn Gauthreaux; Walter A. Kukull; Katya Rascovsky

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. No disponible

Sex differences in blood biomarkers and cognitive performance in individuals with autosomal dominant Alzheimer's disease

Clara Vila‐Castelar; Yinghua Chen; Stephanie Langella; Francisco Lopera; Henrik Zetterberg; Oskar Hansson; Jeffrey L. Dage; Shorena Janelidzde; Yi Su; Kewei Chen; Celina Pluim McDowell; Jairo E. Martinez; Liliana Ramirez‐Gomez; Gloria Garcia; David Aguillon; Ana Baena; Margarita Giraldo‐Chica; Hillary D. Protas; Valentina Ghisays; Silvia Rios‐Romenets; Pierre N. Tariot; Kaj Blennow; Eric M. Reiman; Yakeel T. Quiroz

<jats:title>Abstract</jats:title><jats:sec><jats:title>INTRODUCTION</jats:title><jats:p>Plasma tau phosphorylated at threonine 217 (P‐tau217) and neurofilament light (NfL) have emerged as markers of Alzheimer's disease (AD) pathology. Few studies have examined the role of sex in plasma biomarkers in sporadic AD, yielding mixed findings, and none in autosomal dominant AD.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>We examined the effects of sex and age on plasma P‐tau217 and NfL, and their association with cognitive performance in a cross‐sectional study of 621 Presenilin‐1 E280A mutation carriers (<jats:italic>PSEN1</jats:italic>) and non‐carriers.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>As plasma P‐tau217 levels increase, cognitively unimpaired female carriers showed better cognitive performance than cognitively unimpaired male carriers. Yet, as disease progresses, female carriers had a greater plasma NfL increase than male carriers. There were no sex differences in the association between age and plasma biomarkers among non‐carriers.</jats:p></jats:sec><jats:sec><jats:title>DISCUSSION</jats:title><jats:p>Our findings suggest that, among <jats:italic>PSEN1</jats:italic> mutation carriers, females had a greater rate of neurodegeneration than males, yet it did not predict cognitive performance.</jats:p></jats:sec><jats:sec><jats:title>HIGHLIGHTS</jats:title><jats:p><jats:list list-type="bullet"> <jats:list-item><jats:p>We examined sex differences in plasma P‐tau217 and NfL in Presenilin‐1 E280A (<jats:italic>PSEN1</jats:italic>) mutation carriers and non‐carriers.</jats:p></jats:list-item> <jats:list-item><jats:p>Female carriers had a greater plasma NfL increase, but not P‐tau217, than male carriers.</jats:p></jats:list-item> <jats:list-item><jats:p>As plasma P‐tau217 levels increase, cognitively unimpaired female carriers showed better cognitive performance than cognitively unimpaired male carriers.</jats:p></jats:list-item> <jats:list-item><jats:p>The interaction effect of sex by plasma NfL levels did not predict cognition among carriers.</jats:p></jats:list-item> </jats:list></jats:p></jats:sec>

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. 4127-4138

Response to “Comment on ‘Dementia prevention: The potential long‐term cost‐effectiveness of the FINGER prevention program’”

Anders Wimo; Ron Handels; Riitta Antikainen; Maria Eriksdotter; Linus Jönsson; Martin Knapp; Jenni Kulmala; Tiina Laatikainen; Jenni Lehtisalo; Markku Peltonen; Anders Sköldunger; Hilkka Soininen; Alina Solomon; Timo Strandberg T; Jaakko Tuomilehto; Tiia Ngandu; Miia Kivipelto

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. 4760-4763

The longitudinal early‐onset Alzheimer's disease study (LEADS): Advancing our understanding of Alzheimer's disease in individuals aged 40–64

Donna M. Wilcock

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. No disponible

White matter hyperintensities are higher among early‐onset Alzheimer's disease participants than their cognitively normal and early‐onset nonAD peers: Longitudinal Early‐onset Alzheimer's Disease Study (LEADS)

Ani Eloyan; Maryanne Thangarajah; Na An; Bret J. Borowski; Ashritha L. Reddy; Paul Aisen; Jeffrey L. Dage; Tatiana Foroud; Bernardino Ghetti; Percy Griffin; Dustin Hammers; Leonardo Iaccarino; Clifford R. Jack; Kala Kirby; Joel Kramer; Robert Koeppe; Walter A. Kukull; Renaud La Joie; Nidhi S Mundada; Melissa E. Murray; Kelly Nudelman; Malia Rumbaugh; David N. Soleimani‐Meigooni; Arthur Toga; Alexandra Touroutoglou; Alireza Atri; Gregory S. Day; Ranjan Duara; Neill R. Graff‐Radford; Lawrence S. Honig; David T. Jones; Joseph Masdeu; Mario F. Mendez; Erik Musiek; Chiadi U. Onyike; Emily Rogalski; Stephen Salloway; Sharon Sha; Raymond S. Turner; Thomas S. Wingo; David A. Wolk; Kyle Womack; Laurel Beckett; Sujuan Gao; Maria C. Carrillo; Gil Rabinovici; Liana G. Apostolova; Brad Dickerson; Prashanthi Vemuri;

<jats:title>Abstract</jats:title><jats:sec><jats:title>INTRODUCTION</jats:title><jats:p>We compared white matter hyperintensities (WMHs) in early‐onset Alzheimer's disease (EOAD) with cognitively normal (CN) and early‐onset amyloid‐negative cognitively impaired (EOnonAD) groups in the Longitudinal Early‐Onset Alzheimer's Disease Study.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>We investigated the role of increased WMH in cognition and amyloid and tau burden. We compared WMH burden of 205 EOAD, 68 EOnonAD, and 89 CN participants in lobar regions using <jats:italic>t</jats:italic>‐tests and analyses of covariance. Linear regression analyses were used to investigate the association between WMH and cognitive impairment and that between amyloid and tau burden.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>EOAD showed greater WMHs compared with CN and EOnonAD participants across all regions with no significant differences between CN and EOnonAD groups. Greater WMHs were associated with worse cognition. Tau burden was positively associated with WMH burden in the EOAD group.</jats:p></jats:sec><jats:sec><jats:title>DISCUSSION</jats:title><jats:p>EOAD consistently showed higher WMH volumes. Overall, greater WMHs were associated with worse cognition and higher tau burden in EOAD.</jats:p></jats:sec><jats:sec><jats:title>Highlights</jats:title><jats:p><jats:list list-type="bullet"> <jats:list-item><jats:p>This study represents a comprehensive characterization of WMHs in sporadic EOAD.</jats:p></jats:list-item> <jats:list-item><jats:p>WMH volumes are associated with tau burden from positron emission tomography (PET) in EOAD, suggesting WMHs are correlated with increasing burden of AD.</jats:p></jats:list-item> <jats:list-item><jats:p>Greater WMH volumes are associated with worse performance on global cognitive tests.</jats:p></jats:list-item> <jats:list-item><jats:p>EOAD participants have higher WMH volumes compared with CN and early‐onset amyloid‐negative cognitively impaired (EOnonAD) groups across all brain regions.</jats:p></jats:list-item> </jats:list></jats:p></jats:sec>

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. No disponible