Catálogo de publicaciones - revistas

<jats:p>A gene for mate preference has been shared between hybridizing butterfly species</jats:p>

<jats:p>Constructing human artificial chromosomes in yeast avoids unintended multimerization</jats:p>

<jats:p>Clustering organic cropland can reduce pesticide use on nearby conventional farms</jats:p>

<jats:p>An expert outsider urges a return to basic principles to temper antiaging hype</jats:p>

<jats:p>A planetary scientist recounts an audacious mission to retrieve mineral samples from space</jats:p>

<jats:p> Highlights from the <jats:italic>Science</jats:italic> family of journals </jats:p>

<jats:p>Editors’ selections from the current scientific literature</jats:p>

<jats:p> Bacterial multimodular polyketide synthases (PKSs) are giant enzymes that generate a wide range of therapeutically important but synthetically challenging natural products. Diversification of polyketide structures can be achieved by engineering these enzymes. However, notwithstanding successes made with textbook <jats:italic>cis</jats:italic> -acyltransferase ( <jats:italic>cis</jats:italic> -AT) PKSs, tailoring such large assembly lines remains challenging. Unlike textbook PKSs, <jats:italic>trans</jats:italic> -AT PKSs feature an extraordinary diversity of PKS modules and commonly evolve to form hybrid PKSs. In this study, we analyzed amino acid coevolution to identify a common module site that yields functional PKSs. We used this site to insert and delete diverse PKS parts and create 22 engineered <jats:italic>trans</jats:italic> -AT PKSs from various pathways and in two bacterial producers. The high success rates of our engineering approach highlight the broader applicability to generate complex designer polyketides. </jats:p>

<jats:p>Engineered dissipative reservoirs have the potential to steer many-body quantum systems toward correlated steady states useful for quantum simulation of high-temperature superconductivity or quantum magnetism. Using up to 49 superconducting qubits, we prepared low-energy states of the transverse-field Ising model through coupling to dissipative auxiliary qubits. In one dimension, we observed long-range quantum correlations and a ground-state fidelity of 0.86 for 18 qubits at the critical point. In two dimensions, we found mutual information that extends beyond nearest neighbors. Lastly, by coupling the system to auxiliaries emulating reservoirs with different chemical potentials, we explored transport in the quantum Heisenberg model. Our results establish engineered dissipation as a scalable alternative to unitary evolution for preparing entangled many-body states on noisy quantum processors.</jats:p>