Catálogo de publicaciones - revistas

<jats:p>Protein-coding differences between species often fail to explain phenotypic diversity, suggesting the involvement of genomic elements that regulate gene expression such as enhancers. Identifying associations between enhancers and phenotypes is challenging because enhancer activity can be tissue-dependent and functionally conserved despite low sequence conservation. We developed the Tissue-Aware Conservation Inference Toolkit (TACIT) to associate candidate enhancers with species’ phenotypes using predictions from machine learning models trained on specific tissues. Applying TACIT to associate motor cortex and parvalbumin-positive interneuron enhancers with neurological phenotypes revealed dozens of enhancer–phenotype associations, including brain size–associated enhancers that interact with genes implicated in microcephaly or macrocephaly. TACIT provides a foundation for identifying enhancers associated with the evolution of any convergently evolved phenotype in any large group of species with aligned genomes.</jats:p>

<jats:p>The NCI director and surgical oncologist would fill a 16-month vacancy</jats:p>

<jats:p>Experts split on whether risks of perpetuating racism mean group comparisons should not be done</jats:p>

<jats:p>Two yeast strains mixed in a German brewing cellar 400 years ago</jats:p>

<jats:p>Students and administrators can benefit from new analytics</jats:p>

<jats:p>Policy must support generation of evidence on safety and effectiveness</jats:p>

<jats:p>An analysis of research papers finds differences in article production and recognition for women scientists</jats:p>

<jats:p> Highlights from the <jats:italic>Science</jats:italic> family of journals </jats:p>