Catálogo de publicaciones - revistas

<jats:p>Champion of modern chromatin biology</jats:p>

<jats:p>A bat scientist laments the ecological effects of light pollution</jats:p>

<jats:p>A mechanistic approach to overcoming treatment resistance reveals new targets</jats:p>

<jats:p>Cell atlases of human tolerogenic milieus guide transformative immunotherapies</jats:p>

<jats:p> Highlights from the <jats:italic>Science</jats:italic> family of journals </jats:p>

<jats:p>Editors’ selections from the current scientific literature</jats:p>

<jats:p>Despite the importance of enantioenriched alcohols in medicinal chemistry, total synthesis, and materials science, the efficient and selective construction of enantioenriched tertiary alcohols bearing two contiguous stereocenters has remained a substantial challenge. We report a platform for their preparation through the enantioconvergent, nickel-catalyzed addition of organoboronates to racemic, nonactivated ketones. We prepared several important classes of α,β-chiral tertiary alcohols in a single step with high levels of diastereo- and enantioselectivity through a dynamic kinetic asymmetric addition of aryl and alkenyl nucleophiles. We applied this protocol to modify several profen drugs and to rapidly synthesize biologically relevant molecules. We expect this nickel-catalyzed, base-free ketone racemization process to be a widely applicable strategy for the development of dynamic kinetic processes.</jats:p>

<jats:p>The charge carriers in a material can, under special circumstances, behave as a viscous fluid. In this work, we investigated such behavior by using scanning tunneling potentiometry to probe the nanometer-scale flow of electron fluids in graphene as they pass through channels defined by smooth and tunable in-plane p-n junction barriers. We observed that as the sample temperature and channel widths are increased, the electron fluid flow undergoes a Knudsen-to-Gurzhi transition from the ballistic to the viscous regime characterized by a channel conductance that exceeds the ballistic limit, as well as suppressed charge accumulation against the barriers. Our results are well modeled by finite element simulations of two-dimensional viscous current flow, and they illustrate how Fermi liquid flow evolves with carrier density, channel width, and temperature.</jats:p>

<jats:p> <jats:italic>N</jats:italic> <jats:sup>6</jats:sup> -methyladenosine (m <jats:sup>6</jats:sup> A) is the most abundant messenger RNA (mRNA) modification and plays crucial roles in diverse physiological processes. Using a massively parallel assay for m <jats:sup>6</jats:sup> A (MPm <jats:sup>6</jats:sup> A), we discover that m <jats:sup>6</jats:sup> A specificity is globally regulated by suppressors that prevent m <jats:sup>6</jats:sup> A deposition in unmethylated transcriptome regions. We identify exon junction complexes (EJCs) as m <jats:sup>6</jats:sup> A suppressors that protect exon junction–proximal RNA within coding sequences from methylation and regulate mRNA stability through m <jats:sup>6</jats:sup> A suppression. EJC suppression of m <jats:sup>6</jats:sup> A underlies multiple global characteristics of mRNA m <jats:sup>6</jats:sup> A specificity, with the local range of EJC protection sufficient to suppress m <jats:sup>6</jats:sup> A deposition in average-length internal exons but not in long internal and terminal exons. EJC-suppressed methylation sites colocalize with EJC-suppressed splice sites, which suggests that exon architecture broadly determines local mRNA accessibility to regulatory complexes. </jats:p>