Catálogo de publicaciones - revistas

Compartir en
redes sociales

Science

Resumen/Descripción – provisto por la editorial

No disponible.

Palabras clave – provistas por la editorial

No disponibles.

Disponibilidad

Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde mar. 1997 / hasta dic. 2023	Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

1880-

Cobertura temática

Ciencias naturales

Tabla de contenidos

Verificá que desde tu institución tengas acceso para descargar o solicitar el libro completo o alguno de sus capítulos.

doi: 10.1126/science.278.5338.698

Fyn-Kinase as a Determinant of Ethanol Sensitivity: Relation to NMDA-Receptor Function

Tsuyoshi Miyakawa; Takeshi Yagi; Hiromasa Kitazawa; Masahiro Yasuda; Nobufumi Kawai; Kenta Tsuboi; Hiroaki Niki

<jats:p> Animals vary in their sensitivity to ethanol, a trait at least partly determined by genetic factors. In order to identify possible responsible genes, mice lacking Fyn, a nonâ€“receptor type tyrosine kinase, were investigated. These mice were hypersensitive to the hypnotic effect of ethanol. The administration of ethanol enhanced tyrosine phosphorylation of the <jats:italic>N</jats:italic> -methyl- <jats:sc>d</jats:sc> -aspartate receptor (NMDAR) in the hippocampus of control mice but not in Fyn-deficient mice. An acute tolerance to ethanol inhibition of NMDAR-mediated excitatory postsynaptic potentials in hippocampal slices developed in control mice but not in Fyn-deficient mice. These results indicate that Fyn affects behavioral, biochemical, and physiological responses to ethanol. </jats:p>

Palabras clave: Multidisciplinary.

Pp. 698-701

doi: 10.1126/science.278.5338.702