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Nature

Resumen/Descripción – provisto por la editorial en inglés

Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

1869-

Cobertura temática

Ciencias naturales

Ingeniería y tecnología

Ciencias médicas y de la salud

Ciencias agrícolas y veterinarias

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doi: 10.1038/s41586-024-07155-z

Selfish conflict underlies RNA-mediated parent-of-origin effects

Pinelopi Pliota; Hana Marvanova; Alevtina Koreshova; Yotam Kaufman; Polina Tikanova; Daniel Krogull; Andreas Hagmüller; Sonya A. Widen; Dominik Handler; Joseph Gokcezade; Peter Duchek; Julius Brennecke; Eyal Ben-David; Alejandro Burga

<jats:title>Abstract</jats:title><jats:p>Genomic imprinting—the non-equivalence of maternal and paternal genomes—is a critical process that has evolved independently in many plant and mammalian species<jats:sup>1,2</jats:sup>. According to kinship theory, imprinting is the inevitable consequence of conflictive selective forces acting on differentially expressed parental alleles<jats:sup>3,4</jats:sup>. Yet, how these epigenetic differences evolve in the first place is poorly understood<jats:sup>3,5,6</jats:sup>. Here we report the identification and molecular dissection of a parent-of-origin effect on gene expression that might help to clarify this fundamental question. Toxin-antidote elements (TAs) are selfish elements that spread in populations by poisoning non-carrier individuals<jats:sup>7–9</jats:sup>. In reciprocal crosses between two <jats:italic>Caenorhabditis tropicalis</jats:italic> wild isolates, we found that the <jats:italic>slow-1/grow-1</jats:italic> TA is specifically inactive when paternally inherited. This parent-of-origin effect stems from transcriptional repression of the <jats:italic>slow-1</jats:italic> toxin by the PIWI-interacting RNA (piRNA) host defence pathway. The repression requires PIWI Argonaute and SET-32 histone methyltransferase activities and is transgenerationally inherited via small RNAs. Remarkably, when <jats:italic>slow-1/grow-1</jats:italic> is maternally inherited, <jats:italic>slow-1</jats:italic> repression is halted by a translation-independent role of its maternal mRNA. That is, <jats:italic>slow-1</jats:italic> transcripts loaded into eggs—but not SLOW-1 protein—are necessary and sufficient to counteract piRNA-mediated repression. Our findings show that parent-of-origin effects can evolve by co-option of the piRNA pathway and hinder the spread of selfish genes that require sex for their propagation.</jats:p>

Palabras clave: Multidisciplinary.

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