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Nature

Resumen/Descripción – provisto por la editorial en inglés

Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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No detectada	desde jul. 2012 / hasta dic. 2023	Nature.com
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Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

1869-

Cobertura temática

Ciencias naturales

Ingeniería y tecnología

Ciencias médicas y de la salud

Ciencias agrícolas y veterinarias

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doi: 10.1038/s41586-024-07039-2

Transforming a head direction signal into a goal-oriented steering command

Elena A. Westeinde; Emily Kellogg; Paul M. Dawson; Jenny Lu; Lydia Hamburg; Benjamin Midler; Shaul Druckmann; Rachel I. Wilson

<jats:title>Abstract</jats:title><jats:p>To navigate, we must continuously estimate the direction we are headed in, and we must correct deviations from our goal<jats:sup>1</jats:sup>. Direction estimation is accomplished by ring attractor networks in the head direction system<jats:sup>2,3</jats:sup>. However, we do not fully understand how the sense of direction is used to guide action. <jats:italic>Drosophila</jats:italic> connectome analyses<jats:sup>4,5</jats:sup> reveal three cell populations (PFL3R, PFL3L and PFL2) that connect the head direction system to the locomotor system. Here we use imaging, electrophysiology and chemogenetic stimulation during navigation to show how these populations function. Each population receives a shifted copy of the head direction vector, such that their three reference frames are shifted approximately 120° relative to each other. Each cell type then compares its own head direction vector with a common goal vector; specifically, it evaluates the congruence of these vectors via a nonlinear transformation. The output of all three cell populations is then combined to generate locomotor commands. PFL3R cells are recruited when the fly is oriented to the left of its goal, and their activity drives rightward turning; the reverse is true for PFL3L. Meanwhile, PFL2 cells increase steering speed, and are recruited when the fly is oriented far from its goal. PFL2 cells adaptively increase the strength of steering as directional error increases, effectively managing the tradeoff between speed and accuracy. Together, our results show how a map of space in the brain can be combined with an internal goal to generate action commands, via a transformation from world-centric coordinates to body-centric coordinates.</jats:p>

Palabras clave: Multidisciplinary.

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