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Introduction to Computational Biology: An Evolutionary Approach

Bernhard Haubold Thomas Wiehe

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Institución detectada Año de publicación Navegá Descargá Solicitá
No detectada 2006 SpringerLink

Información

Tipo de recurso:

libros

ISBN impreso

978-3-7643-6700-8

ISBN electrónico

978-3-7643-7387-0

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

Información sobre derechos de publicación

© Birkhäuser Verlag 2006

Cobertura temática

Tabla de contenidos

Genes in Populations: Backward in Time

In this chapter we have turned the Wright-Fisher model of gene dynamics on its head. Given a sample of n genes, their lineages coalesce into common ancestors as we move backward in time. If we trace back the gene genealogies until the most recent common ancestor of the entire sample, this sample genealogy is called the coalescent. Coalescent theory allows the derivation of important evolutionary quantities such as the number of segregating sites expected under neutrality. In addition, the coalescent is routinely used as a very efficient tool for simulating gene samples under a diverse range of evolutionary scenarios, including recombination and selection.

Palabras clave: Recent Common Ancestor; Much Recent Common Ancestor; Coalescence Time; Gene Genealogy; Ancestral Recombination Graph.

Part II - Sequences in Time | Pp. 217-243

Testing Evolutionary Hypotheses

Palabras clave: Evolutionary Hypothesis; Linkage Equilibrium; External Branch; Single Nucleotide Polymor; Reciprocal Recombination.

Part II - Sequences in Time | Pp. 245-258