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Pregnant women with APS are at risk of complications at all stages of pregnancy. They require specialist care and a team approach involving obstetricians, obstetric physicians, rheumatologists, hematologists, neonatologists, and specialist midwives. Close monitoring of the various aspects of the condition may reduce maternal morbidity and improve fetal outcome. Therapeutic options include aspirin, LMWH, and, less commonly, warfarin and steroids.

The pathogenesis of the adverse pregnancy outcome in APS has not yet been fully elucidated although there is active research in this field. Until this is ascertained, we must accept that many aspects of management are purely empirical and it is our duty to counsel women thoroughly such that they understand the risks and benefits of the treatment options they are offered.