Catálogo de publicaciones - libros
Título de Acceso Abierto
Second Assessment of Climate Change for the Baltic Sea Basin
Parte de: Regional Climate Studies
Resumen/Descripción – provisto por la editorial
No disponible.
Palabras clave – provistas por la editorial
Earth System Sciences; Atmospheric Sciences; Baltic Sea; Environmental Impacts; Regional Climate Change; Regional Climate Projections
Disponibilidad
| Institución detectada | Año de publicación | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No requiere | 2016 | Directory of Open access Books |
| |
| No requiere | 2016 | SpringerLink |
|
Información
Tipo de recurso:
libros
ISBN impreso
978-3-319-27068-5
ISBN electrónico
978-3-319-27069-2
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
2016
Tabla de contenidos
The Genetics of Autism Spectrum Disorders
Guillaume Huguet; Marion Benabou; Thomas Bourgeron
In the last 30 years, twin studies have indicated a strong genetic contribution to Autism Spectrum Disorders (ASD). The heritability of ASD is estimated to be 50 %, mostly captured by still unknown common variants. In approximately 10 % of patients with ASD, especially those with intellectual disability, copy number or single nucleotide variants affecting clinically relevant genes for ASD can be identified. Given the function of these genes, it was hypothesized that abnormal synaptic plasticity and failure of neuronal/synaptic homeostasis could increase the risk of ASD. In parallel, abnormal levels of blood serotonin and melatonin were reported in a subset of patients with ASD. These biochemical imbalances could act as risk factors for the sleep/circadian disorders that are often observed in individuals with ASD. Here, we review the main pathways associated with ASD, with a focus on the roles of the synapse and the serotonin-NAS-melatonin pathway in the susceptibility of ASD.
Pp. 101-129