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Egbert Harzheim
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Disponibilidad
Institución detectada | Año de publicación | Navegá | Descargá | Solicitá |
---|---|---|---|---|
No detectada | 2005 | SpringerLink |
Información
Tipo de recurso:
libros
ISBN impreso
978-0-387-24219-4
ISBN electrónico
978-0-387-24222-4
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
2005
Información sobre derechos de publicación
© Springer Science+Business Media, Inc. 2005
Cobertura temática
Tabla de contenidos
Comparison of order types
Egbert Harzheim
Glutamate production is a typical success in industrial fermentation. Annual production of glutamate by is over 1.5 million tons per year worldwide. It is well known that there are some triggers of glutamate overproduction by : depletion of biotin, which is required for cell growth; addition of detergent; addition of β-lactam antibiotics such as penicillin; and addition of ethambutol or cerulenin. A marked change in metabolic pathways occurs after glutamate overproduction is triggered. In this chapter, recent studies on the molecular mechanisms of glutamate production are described with a particular focus on triggering mechanisms, changes in key enzyme activities, and secretion of glutamate. Recent advances in genome-wide studies, including genomics, proteomics, metabolomics, and on metabolic flux analysis of flux redistribution during glutamate overproduction are discussed as well. The biosynthesis of the related amino acids glutamine and proline and strategies for their overproduction are also described.
Pp. 331-352
Comparability graphs
Egbert Harzheim
Glutamate production is a typical success in industrial fermentation. Annual production of glutamate by is over 1.5 million tons per year worldwide. It is well known that there are some triggers of glutamate overproduction by : depletion of biotin, which is required for cell growth; addition of detergent; addition of β-lactam antibiotics such as penicillin; and addition of ethambutol or cerulenin. A marked change in metabolic pathways occurs after glutamate overproduction is triggered. In this chapter, recent studies on the molecular mechanisms of glutamate production are described with a particular focus on triggering mechanisms, changes in key enzyme activities, and secretion of glutamate. Recent advances in genome-wide studies, including genomics, proteomics, metabolomics, and on metabolic flux analysis of flux redistribution during glutamate overproduction are discussed as well. The biosynthesis of the related amino acids glutamine and proline and strategies for their overproduction are also described.
Pp. 353-368