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Alzheimer's and Dementia: The Journal of the Alzheimer's Association

Resumen/Descripción – provisto por la editorial en inglés
The mission of Alzheimer's & Dementia: Journal of the Alzheimer's Association is to bridge the knowledge gaps across a wide range of bench-to-bedside investigation. The journal publishes the results of studies in: behavior, biochemistry, genetics, molecular biology, pharmacology, physiology, protein chemistry, neurology, neuropathology, psychiatry, geriatrics, neuropsychology, epidemiology, sociology, health services research, health economics, political science and public policy. Content emphasizes interdisciplinary investigations, integrative/translational articles, related to: etiology, risk factors, early detection, disease modifying interventions, prevention of dementia and applications of new technologies in health services. The journal publishes • comprehensive reviews; • research articles; • information on clinical trials; • short reports;
• in-depth perspectives/open-peer commentaries; • theoretical and/or translational papers that attempt integrate knowledge across discipline;
• history & politics of science/brief biographies and, • abstracts of papers presented at international meetings. Negative results, particularly clinical trials, are published as short communications.

The ultimate objective is to create a novel forum for: • rapid communication of new findings, ideas or perspectives; • disseminating knowledge, across the spectrum of basic to clinical studies, necessary for optimal translation of research findings into practical applications/interventions; • integrating knowledge across disciplines; • increase knowledge in diverse disciplines to promote early detection/diagnosis and/or interventions; • formulating new theories and/or strategies for the rigorous testing of theories or their predictions; • identifying promising new directions of research and, • providing the scientific impetus for new initiatives; or public policies concerning research on prevention and new models of health services.

Alzheimer's & Dementia is indexed/abstracted in Index Medicus/MEDLINE, Scopus, Science Citation Index Expanded (SciSearch®), Current Contents®/Clinical Medicine, Neuroscience Citation Index®, and Journal Citation Reports/Science Edition.
Palabras clave – provistas por la editorial

No disponibles.

Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde ene. 2005 / hasta dic. 2023 Wiley Online Library

Información

Tipo de recurso:

revistas

ISSN impreso

1552-5260

ISSN electrónico

1552-5279

Editor responsable

Elsevier

País de edición

Países Bajos

Fecha de publicación

Tabla de contenidos

2022 Alzheimer's disease facts and figures

<jats:title>Abstract</jats:title><jats:p>This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society. The Special Report discusses consumers' and primary care physicians' perspectives on awareness, diagnosis and treatment of mild cognitive impairment (MCI), including MCI due to Alzheimer's disease. An estimated 6.5 million Americans age 65 and older are living with Alzheimer's dementia today. This number could grow to 13.8 million by 2060 barring the development of medical breakthroughs to prevent, slow or cure AD. Official death certificates recorded 121,499 deaths from AD in 2019, the latest year for which data are available. Alzheimer's disease was officially listed as the sixth‐leading cause of death in the United States in 2019 and the seventh‐leading cause of death in 2020 and 2021, when COVID‐19 entered the ranks of the top ten causes of death. Alzheimer's remains the fifth‐leading cause of death among Americans age 65 and older. Between 2000 and 2019, deaths from stroke, heart disease and HIV decreased, whereas reported deaths from AD increased more than 145%. More than 11 million family members and other unpaid caregivers provided an estimated 16 billion hours of care to people with Alzheimer's or other dementias in 2021. These figures reflect a decline in the number of caregivers compared with a decade earlier, as well as an increase in the amount of care provided by each remaining caregiver. Unpaid dementia caregiving was valued at $271.6 billion in 2021. Its costs, however, extend to family caregivers’ increased risk for emotional distress and negative mental and physical health outcomes — costs that have been aggravated by COVID‐19. Members of the dementia care workforce have also been affected by COVID‐19. As essential care workers, some have opted to change jobs to protect their own health and the health of their families. However, this occurs at a time when more members of the dementia care workforce are needed. Average per‐person Medicare payments for services to beneficiaries age 65 and older with AD or other dementias are almost three times as great as payments for beneficiaries without these conditions, and Medicaid payments are more than 22 times as great. Total payments in 2022 for health care, long‐term care and hospice services for people age 65 and older with dementia are estimated to be $321 billion. A recent survey commissioned by the Alzheimer's Association revealed several barriers to consumers’ understanding of MCI. The survey showed low awareness of MCI among Americans, a reluctance among Americans to see their doctor after noticing MCI symptoms, and persistent challenges for primary care physicians in diagnosing MCI. Survey results indicate the need to improve MCI awareness and diagnosis, especially in underserved communities, and to encourage greater participation in MCI‐related clinical trials.</jats:p>

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. 700-789

Screening and enrollment of underrepresented ethnocultural and educational populations in the Alzheimer's Disease Neuroimaging Initiative (ADNI)

Miriam T. Ashford; Rema Raman; Garrett Miller; Michael C. Donohue; Ozioma C. Okonkwo; Monica Rivera Mindt; Rachel L. Nosheny; Godfrey A. Coker; Ronald C. Petersen; Paul S. Aisen; Michael W. Weiner;

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. 2603-2613

Cross‐sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle‐aged individuals with a parental history of either autosomal dominant or late‐onset Alzheimer's disease

Chengjie Xiong; Lena M. McCue; Virginia Buckles; Elizabeth Grant; Folasade Agboola; Dean Coble; Randall J. Bateman; Anne M Fagan; Tammie L. S. Benzinger; Jason Hassenstab; Suzanne E. Schindler; Eric McDade; Krista Moulder; Brian A. Gordon; Carlos Cruchaga; Gregory S. Day; Takeshi Ikeuchi; Kazushi Suzuki; Ricardo F. Allegri; Jonathan Vöglein; Johannes Levin; John C. Morris;

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. No disponible

The Nairobi Declaration—Reducing the burden of dementia in low‐ and middle‐income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs

Gladys Maestre; Maria Carrillo; Raj Kalaria; Daisy Acosta; Larry Adams; Thierry Adoukonou; Kazeem Akinwande; Joshua Akinyemi; Rufus Akinyemi; Onoja Akpa; Suvarna Alladi; Ricardo Allegri; Raul Arizaga; Faheem Arshad; Oyedunni Arulogun; David Babalola; Olusegun Baiyewu; Thomas Bak; Tarek Bellaj; Judith Boshe; Carol Brayne; David Brodie‐Mends; Richard Brown; Jennifer Cahn; Nkouonlack Cyrille; Albertino Damasceno; Ranil de Silva; Rohan de Silva; Mamuka Djibuti; Anna Jane Dreyer; Ratnavalli Ellajosyula; Temitope Farombi; Bernard Fongang; Stefania Forner; Rob Friedland; Noe Garza; Antoine Gbessemehlan; Eliza (Eleni‐ Zacharoula) Georgiou; Riadh Gouider; Ishtar Govia; Lea Grinberg; Maëlenn Guerchet; Seid Gugssa; Joy Louise Gumikiriza‐Onoria; Deborah Gustafson; Eef Hogervorst; Michael Hornberger; Agustin Ibanez; Masafumi Ihara; Ozama Ismail; Thomas Issac; Linus Jönsson; Celestin Kaputu; Wambui Karanja; Jackline Karungi; Desire Tshala‐Katumbay; Brian Kunkle; Joseph H Lee; Iracema Leroi; Raphaella Lewis; Gill Livingston; Francisco Lopera; Kamada Lwere; Facundo Manes; Lingani Mbakile‐Mahlanza; Pedro Mena; Bruce Miller; Athanase Millogo; Abdul Mohamed; Christine Musyimi; Victoria Mutiso; Noeline Nakasujja; David Ndetei; Sam Nightingale; Alfred K. Njamnshi; Gabriela Novotni; Primrose Nyamayaro; Solomon Nyame; Julius Ogeng'o; Adesola Ogunniyi; Maira Okada De Oliveira; Njideka Okubadejo; Martin Orrell; Akintunde Orunmuyi; Mayowa Owolabi; Stella Paddick; Margaret A Pericak‐Vance; Zvezdan Pirtosek; Felix Potocnik; Bill Preston; Rema Raman; Kirti Ranchod; Mie Rizig; Monica Rosselli; Roy Deepa; Upal Roy; Marufjon Salokhiddinov; Mary Sano; Fred Sarfo; Claudia L Satizabal; Diego Sepulveda‐Falla; Sudha Seshadri; Claire Sexton; Ingmar Skoog; Peter St George‐Hyslop; Claudia Suemoto; Jeremy Tanner; Prekshya Thapa; Kamadore Toure; Valentine Ucheagwu; Chinedu Udeh‐Momoh; Victor Valcour; Jeffery Vance; Mathew Varghese; Jaime Vera; Richard Walker; Wendy Weidner; Walsh Sebastian; Patrice Whitehead Gay; Henrik Zetterberg; Yared Zewde;

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. 1105-1108

Dissipating the fog: Cognitive trajectories and risk factors 1 year after COVID‐19 hospitalization

Natalia Gomes Gonçalves; Márlon Juliano Romero Aliberti; Laiss Bertola; Thiago Avelino‐Silva; Murilo Bacchini Dias; Daniel Apolinario; Geraldo Busatto; Orestes Forlenza; Ricardo Nitrini; Sonia Maria Dozzi Brucki; Andre Russowsky Brunoni; Kallene Summer Moreira Vidal; Wilson Jacob‐Filho; Claudia Kimie Suemoto;

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. No disponible

Vitamin D intake and cognitive decline in Blacks and Whites: The role of diet and supplements

Klodian Dhana; Lisa L. Barnes; Puja Agarwal; Xiaoran Liu; Anisa Dhana; Pankaja Desai; Neelum Aggarwal; Denis A. Evans; Kumar B. Rajan

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. 1135-1142

Cost effectiveness of non‐drug interventions that reduce nursing home admissions for people living with dementia

Eric Jutkowitz; Laura T. Pizzi; Peter Shewmaker; Fernando Alarid‐Escudero; Gary Epstein‐Lubow; Katherine M. Prioli; Joseph E. Gaugler; Laura N. Gitlin

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. No disponible

Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm‐FINGERS): Study design and harmonization

Lucia Crivelli; Ismael Luis Calandri; Claudia Kimie Suemoto; Rosa María Salinas; Lina Marcela Velilla; Mônica Sanches Yassuda; Paulo Caramelli; Francisco Lopera; Ricardo Nitrini; Gustavo Emilio Sevlever; Ana Luisa Sosa; Daisy Acosta; Ana María Charamelo Baietti; María Isabel Cusicanqui; Nilton Custodio; Sergio Dansilio De Simone; Carolina Delgado Derio; Lissette Duque‐Peñailillo; Juan Carlos Duran; Ivonne Z. Jiménez‐Velázquez; Jorge Mario Leon‐Salas; Yanina Bergamo; María Florencia Clarens; Andrés Damian; Ignacio Demey; María Belén Helou; Carlos Márquez; María Eugenia Martin; Maria da Graça Morais Martin; Diego Querze; Ezequiel Ignacio Surace; Sabrina Acosta‐Egea; Esteban Aguirre–Salvador; Leonardo Cruz de Souza; Gustavo Henrique da Cunha Peixoto Cançado; Sonia Maria Dozzi Brucki; Clarisse Vasconcelos Friedlaender; Karina Braga Gomes; Myriam Gutierrez; Carlos Laforcada Ríos; Joyce Graciela Martinez Galindo; Rosa Montesinos; Alberto Nuñez‐Herrera; Sebastián Ospina‐Henao; Guillermina Rodríguez; Victoria Ruiz Masson; Mónica Sánchez; Christian E. Schenk; Ligia Soto; Maira Tonidandel Barbosa; Jéssica Abdo Gonçalves Tosatti; Yosselin Vicuña; Mark Espeland; Krister Hakansson; Miia Kivipelto; Laura Baker; Heather Snyder; María Carrillo; Ricardo Francisco Allegri

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. No disponible

Demographically‐adjusted normative data among Latinos for the version 3 of the Alzheimer's Disease Centers’ Neuropsychological Test Battery in the Uniform Data Set

María J. Marquine; Adam Parks; Jaime Perales‐Puchalt; David A. González; Mónica Rosado‐Bruno; Rebecca North; Carl Pieper; Amy E. Werry; Andrew Kiselica; Silvia Chapman; Hiroko Dodge; Kathryn Gauthreaux; Walter A. Kukull; Katya Rascovsky

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. No disponible

Sex differences in blood biomarkers and cognitive performance in individuals with autosomal dominant Alzheimer's disease

Clara Vila‐Castelar; Yinghua Chen; Stephanie Langella; Francisco Lopera; Henrik Zetterberg; Oskar Hansson; Jeffrey L. Dage; Shorena Janelidzde; Yi Su; Kewei Chen; Celina Pluim McDowell; Jairo E. Martinez; Liliana Ramirez‐Gomez; Gloria Garcia; David Aguillon; Ana Baena; Margarita Giraldo‐Chica; Hillary D. Protas; Valentina Ghisays; Silvia Rios‐Romenets; Pierre N. Tariot; Kaj Blennow; Eric M. Reiman; Yakeel T. Quiroz

<jats:title>Abstract</jats:title><jats:sec><jats:title>INTRODUCTION</jats:title><jats:p>Plasma tau phosphorylated at threonine 217 (P‐tau217) and neurofilament light (NfL) have emerged as markers of Alzheimer's disease (AD) pathology. Few studies have examined the role of sex in plasma biomarkers in sporadic AD, yielding mixed findings, and none in autosomal dominant AD.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>We examined the effects of sex and age on plasma P‐tau217 and NfL, and their association with cognitive performance in a cross‐sectional study of 621 Presenilin‐1 E280A mutation carriers (<jats:italic>PSEN1</jats:italic>) and non‐carriers.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>As plasma P‐tau217 levels increase, cognitively unimpaired female carriers showed better cognitive performance than cognitively unimpaired male carriers. Yet, as disease progresses, female carriers had a greater plasma NfL increase than male carriers. There were no sex differences in the association between age and plasma biomarkers among non‐carriers.</jats:p></jats:sec><jats:sec><jats:title>DISCUSSION</jats:title><jats:p>Our findings suggest that, among <jats:italic>PSEN1</jats:italic> mutation carriers, females had a greater rate of neurodegeneration than males, yet it did not predict cognitive performance.</jats:p></jats:sec><jats:sec><jats:title>HIGHLIGHTS</jats:title><jats:p><jats:list list-type="bullet"> <jats:list-item><jats:p>We examined sex differences in plasma P‐tau217 and NfL in Presenilin‐1 E280A (<jats:italic>PSEN1</jats:italic>) mutation carriers and non‐carriers.</jats:p></jats:list-item> <jats:list-item><jats:p>Female carriers had a greater plasma NfL increase, but not P‐tau217, than male carriers.</jats:p></jats:list-item> <jats:list-item><jats:p>As plasma P‐tau217 levels increase, cognitively unimpaired female carriers showed better cognitive performance than cognitively unimpaired male carriers.</jats:p></jats:list-item> <jats:list-item><jats:p>The interaction effect of sex by plasma NfL levels did not predict cognition among carriers.</jats:p></jats:list-item> </jats:list></jats:p></jats:sec>

Palabras clave: Psychiatry and Mental health; Cellular and Molecular Neuroscience; Geriatrics and Gerontology; Neurology (clinical); Developmental Neuroscience; Health Policy; Epidemiology.

Pp. 4127-4138