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World Journal of Microbiology and Biotechnology

Resumen/Descripción – provisto por la editorial en inglés

World Journal of Microbiology & Biotechnology publishes research papers, short communications and review articles on all aspects of applied microbiology and biotechnology. Virological, veterinary and clinical topics however are outside the scope of the journal. The Journal provides a forum for research work directed towards microbiological and biotechnological solutions to global problems encouraging contributions from all scientists from all across the globe who have an interest in tackling them. As many global issues, for example improving crop productivity, public health and waste management, have more acute consequences in the developing world, the Journal emphasizes the role of biotechnological advances, for and from developing regions.

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Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde ene. 1997 / hasta dic. 2023	SpringerLink

Información

Tipo de recurso:

revistas

ISSN impreso

0959-3993

ISSN electrónico

1573-0972

Editor responsable

Taylor & Francis Group (TFG)

País de edición

Reino Unido

Fecha de publicación

1990-

Cobertura temática

Ciencias biológicas

Biotecnología industrial

Ciencias médicas y de la salud

Tabla de contenidos

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doi: 10.1007/s11274-023-03745-7

Curcumin clarithromycin nano-form a promising agent to fight Helicobacter pylori infections

Farag M. Mosallam; Mahmoud M. Bendary; Rana Elshimy; Ahmed I. El-Batal

<jats:title>Abstract</jats:title><jats:p><jats:italic>Helicobacter pylori</jats:italic> (<jats:italic>H. pylori</jats:italic>) is the main cause of gastric diseases. However, the traditional antibiotic treatment of <jats:italic>H. pylori</jats:italic> is limited due to increased antibiotic resistance, low efficacy, and low drug concentration in the stomach. This study developed a Nano-emulsion system with ability to carry Curcumin and Clarithromycin to protect them against stomach acidity and increase their efficacy against <jats:italic>H. pylori.</jats:italic> We used oil in water emulsion system to prepare a novel Curcumin Clarithromycin Nano-Emulsion (Cur-CLR-NE). The nano-emulsion was validated by dynamic light scattering (DLS) technique, zeta potential; transmission electron microscopy (mean particle size 48 nm), UV–visible scanning and Fourier transform infrared spectroscopy (FT-IR). The in vitro assay of Cur-CLR-NE against <jats:italic>H. pylori</jats:italic> was evaluated by minimum inhibitory concentration (12.5 to 6.26 µg/mL), minimum bactericidal concentration (MBC) and anti-biofilm that showed a higher inhibitory effect of Cur-CLR-NE in compere with, free curcumin and clarithromycin against <jats:italic>H. pylori</jats:italic>. The in vivo results indicated that Cur-CLR-NE showed higher <jats:italic>H. pylori</jats:italic> clearance effect than free clarithromycin or curcumin under the same administration frequency and the same dose regimen. Histological analysis clearly showed that curcumin is highly effective in repairing damaged tissue. In addition, a potent synergistic effect was obvious between clarithromycin and curcumin in nano-emulsion system. The inflammation, superficial damage, the symptoms of gastritis including erosion in the mouse gastric mucosa, necrosis of the gastric epithelium gastric glands and interstitial oedema of tunica muscularis were observed in the positive control infected mice and absent from treated mice with Cur-CLR-NE.</jats:p>