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<jats:title>Abstract</jats:title> <jats:p>We present a novel method for obtaining a 3D absorption map of a tissue-like turbid slab in the near-infrared spectral range by tomosynthesis. Transmittance data are obtained for a large number of oblique projection directions by scanning a cw laser source across the surface of the slab and by using a CCD camera for spatially resolved light detection. A perturbation model of light transport is used to convert the intensity maps for the different projections into absorption maps. By applying the tomosynthesis approach to these new maps, 3D absorption information on embedded inclusions has been obtained for the first time. The number and the positions of the lateral offset detectors have been optimized by employing a structural similarity index for comparison of the reconstructed with the true absorption data. We present 3D reconstruction of absorption maps using both Monte Carlo simulations and experiments on phantoms with breast-like optical properties. A comparison with conventional 3D reconstruction by a finite element approach shows the superior location performance of tomosynthesis.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>Spinal fusion with pedicle-screw-rod is being used widely for treating spinal deformities diseases. Several biomechanical studies on screw rod based implant failure through screw pullout, bending, screw breakage have been performed. But few studies are available regarding the effect of strain for breakage of rod. So, the purpose of the present study is to observe strain at the rod connected with the pedicle screw for different loading condition. The strain in stainless steel (SS) connecting rods for pedicle screw fixation were measured using strain gauge. In order to investigate the bio-mechanical response of lumbar spine with reference to strain in the rod, a simple experimental setup was developed using a specimen of L1-S spine segment. SS rods were used for pedicle screw implant on prototyped lumbar Spine. Prior to testing with pedicle screw, the lumbar spine specimen was also compared with FE results. The strain measured using strain gauges at L3-L4 level on SS rod were within a range of 85 to 310 microstrain under 6, 8, 10 Nm flexion and extension, and for L4-L5 level, these values were within a range of 95 to 440 microstrain. It was found that FE result was higher than the strain gauge result and the error varied between 10.5% to 33% with average error of 22.8%. However similar stain behavior was observed by the FE analysis. The proposed method, as well as the qualitative data, might be helpful for the researchers to understand biomechanical behavior of pedicle-screw implanted spine.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>An innovative basic fibroblast growth factor (bFGF)-loaded polycaprolactone (PCL) fibrous membrane with highly aligned structure is developed for guided tissue regeneration (GTR). The aligned membrane is fabricated by electrospinning. In order to make efficient use of bFGF, PCL electrospun fibrous membrane is firstly surface-coated by self-polymerization of dopamine, and followed by immobilization of heparin via covalent conjugation to the polydopamine (PDA) layer. Subsequently, bFGF is loaded by binding to heparin. The loading yield of bFGF on heparin-immobilized PDA-coated PCL membrane significantly increases to around 7 times as compared with that of pure PCL membrane. NIH-3T3 cells show an enhanced proliferation and exhibit a stretched morphology aligned along the direction of the fibers on the aligned membranes. However, aligned bFGF-loaded PCL membrane exhibit a similar morphology but a highest cell density prolonged till 9 days. The synergetic effect of growth factor and topography would effectively regulate cell proliferation.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>Proton beam treatment is being looked favourably now in breast treatment. Tissue expanders are often placed after mastectomy that contains metallic port for saline injection which produces dose perturbations in proton beam therapy with uncertain dosimetry. Dose perturbation for a stainless-steel injection port from a breast implant is investigated in this study. Measurements, Monte-Carlo simulation, and calculated dose distribution of plans based on kVCT and MVCT images are compared. Treatment plans are performed on kVCT and MVCT images to observe the effect of metal artifact from the breast implant. The kVCT based plan underestimates the beam range due to the overestimated water equivalent thickness of the metal ports as a result of image degradation. Compared to the measurement with metal port in the proton beam, the MVCT-based treatment planning provides more accurate dose calculation than the kVCT-based results. The dose perturbation factor calculated from MVCT planning is within 10% of the measurement results while HU corrected kVCT plan still shows dose difference as large as 100% due to the incorrect range pull back calculation caused by the misrepresentation of the volume between the plastic cap and the stainless-steel base. The dose enhancement observed at the metal and solid water interface is as large as 15%, which needs to be accounted for in the planning process if there is a clinical concern. Dose reduction as large as 16% is observed with depth from 1 cm to 4 cm underneath the thickest part of the metallic port whereas lateral dose perturbation is also seen up to 7 mm. The measurement data are supported by the Monte-Carlo simulated results with a maximum dose difference of 6%. It is concluded that if proton beam is used with metallic port, MVCT imaging data is recommended. In lieu of MVCT, DECT, CT scanner with metal artifact reduction software or in the very least, extended HU range should be used to reduce the streaking artifact as well as to produce a more accurate image of the metallic port.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>Applying the concept of linear energy transfer (LET) to modelling of biological effects of charged particles usually involves calculation of the average LET. To calculate this, the energy distribution of particles is characterized by either the source spectrum or fluence spectrum. Also, the average can be frequency- or dose-weighted. This makes four methods of calculating the average LET, each producing a different number. The purpose of this note is to describe which of these four methods is best suited for radiobiological modelling. We focused on data for photons (x-rays and gamma radiation) because in this case differences in the four averaging methods are most pronounced. However, our conclusions are equally applicable to photons and hadrons. We based our arguments on recently emerged Monte Carlo data that fully account for transport of electrons down to very low energies comparable to the ionization potential of water. We concluded that the frequency average LET calculated using the fluence spectrum has better predictive power than does that calculated using any of the other three options. This optimal method is not new but is different from those currently dominating research in this area.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>Bone is a dynamic biological tissue that acts as the primary rigid support of the body. Several systemic factors are responsible for pathologies that negatively affect its structural attributes. Although the bone is in continuous renewal by osteogenesis, metabolic diseases are the most common affectations that alter its natural equilibrium. Different techniques based on ionizing radiation are used for the bone diagnosis restrictively. However, if these are not used adequately, the application could present risks for human health. In this paper, it is proposed and explored a new technique to apply an early-stage diagnosis of bone variations. The technique evaluates bone structural conditions from the teeth (used as probes) by applying a structural health monitoring (SHM) methodology. An experimental procedure is described to identify the stiffness variations produced by mechanical drillings done in prepared bone samples. The identification is carried out applying the electromechanical impedance technique (EMI) through a piezo-actuated device in the frequency spectrum 5–20kHz. Three bone samples with incorporated teeth (three teeth, two teeth, and one tooth) were prepared to emulate a mandibular portion of alveolar bone-PDL (periodontal ligament)-tooth system. Piezo-device was attached to the crown of the tooth with an orthodontic bracket allowing the teeth to act as probes. The electrical resistance measurements were computed with an electrical decoupling approach that improved the detection of the drillings; it was due to the increment of the sensitivity of the signals. The results showed that the bone mass reduction is correlated with statistical indices obtained in specific frequency intervals of the electrical resistance. This work suggests the possibility of a future application addressed to a bone diagnosis in a non-invasive way.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>Mitral Valve Prolapse (MVP) is a common condition among people, which is often benign and does not need any serious treatment. However, this doesn’t mean that MVP can’t cause any problems. In malignant conditions, MVP can cause mitral failure and also heart failure. Early diagnosis of MVP is significantly important to control and reduce its complications. Since the phonocardiogram signal provides useful information about heart valves function, it can be used for MVP detection. To detect MVP, the signal was denoised and segmented into heart cycles and constant three-second pieces in the first and second approaches, respectively. Next, based on the Fractional Fourier Transform (FrFT), the desired features were extracted. Then, the extracted features were windowed by a Moving Logarithmic Median Window (MLMW) and optimum features were selected using Mahalanobis, Bhattacharyya, Canberra, and Minkowski distance criteria. Finally, using the selected features, classification was performed by using the K-Nearest Neighbor (KNN) and the Suppor Vector Machine (SVM) classifiers to find out whether a segment is prolapsed. The best results of the experiment on the collected database contain 15 prolapsed and 6 non-prolapsed subjects using the A-test method show 96.25 ± 2.43 accuracy, 98.5 ± 3.37 sensitivity, 94.0 ± 5.16 specificity, 96.0 ± 3.44 precision, 92.5 ± 4.86 kappa, and 96.6 ± 2.34 f-score with the SVM classifier.</jats:p>

<jats:title>Abstract</jats:title> <jats:p> <jats:italic> <jats:bold>Aim</jats:bold> </jats:italic>: The purpose of the current study was to compare between deep inspiration breath-hold (DIBH) and free-breathing (FB) method in the setup reproducibility and to perform a dosimetric comparison between both methods in left-sided breast cancer patients who undergo the UK FAST trial. <jats:italic> <jats:bold>Materials and methods</jats:bold> </jats:italic>: The online matching correction data were retrospectively collected for 50 patients treated with the FAST trial. They were equally divided into DIBH and FB groups to compare between both methods in the setup reproducibility and create the appropriate planning target volume (PTV) margin. Ten patients out of the fifty were scanned in DIBH and FB to perform a dosimetric comparison with the strict acceptance criteria of the FAST trial. <jats:italic> <jats:bold>Results</jats:bold> </jats:italic>: All heart dosimetric parameters of the DIBH was significantly lower than that of FB (p &lt; 0.001), and the lung V<jats:sub>30%</jats:sub> of DIBH plans was significantly lower than FB plans (p = 0.03). There was no statistically significant difference between the two methods in the other organs at risk doses. To fulfill the heart and lung constraints in FB plans, the PTV V<jats:sub>90%</jats:sub> was reduced by 3.4%, and three plans would not attain the PTV acceptance criteria. There was no significant difference between the systematic or random setup errors between both methods except the left-right random shift was significantly lower in DIBH cases (p = 0.004). The calculated PTV margins were (4 mm, 3 mm, and 4 mm) for DIBH group, and (5 mm, 6 mm, and 8 mm) for FB group in the anterior-posterior, superior-inferior, and left-right shifts, respectively. <jats:italic> <jats:bold>Conclusion</jats:bold> </jats:italic>: It is highly warranted to treat left-sided breast cancer patients with the DIBH technique when the UK FAST trial is employed for treatment.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>Indirect dosimetry to calculate peak skin dose (PSD) is generally based on reference air kerma or kerma-area-product, with effects of table attenuation, inverse square law and backscatter factor applied. When the incident x-ray beam angle changes, these factors would change as well. The purpose of this study is to identify the impact of incident x-ray beam angle on the accuracy of indirect PSD calculation and develop a correction method. Monte Carlo simulation was conducted to assist analytical equation derivation and to validate the developed analytical method. Direct PSD measurements were performed a Siemens Artis Zee biplane fluoroscopy and a GE OEC C-Arm at different angles to validate the proposed correction method and its independence of fluoroscopy systems. Compared with MC simulated PSD, the derived analytical equation successfully predicts these PSD changes for incident angles of 0, 15, 30 and 40 degrees, with the residual error magnitude of 0.3%–3.1% corresponding to different SSDs. The agreement between calculated PSD also agrees well with direct measurement.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>Electronic micro and nano-devices are suitable tools to monitor the activity of many individual neurons over mesoscale networks. However the inorganic materials currently used in microelectronics are barely accepted by neural cells and tissues, thus limiting both the sensor lifetime and efficiency. In particular, penetrating intracortical probes face high failure rate because of a wide immune response of cells and tissues. This adverse reaction called gliosis leads to the rejection of the implanted probe after few weeks and prevent long-lasting recordings of cortical neurons. Such acceptance issue impedes the realization of many neuro-rehabilitation projects. To overcome this, graphene and related carbon-based materials have attracted a lot of interest regarding their positive impact on the adhesion and regeneration of neurons, and their ability to provide high-sensitive electronic devices, such as graphene field effect transistor (G-FET). Such devices can also be implemented on numerous suitable substrates including soft substrates to match the mechanical compliance of cells and tissues, improving further the biocompatibility of the implants. Thus, using graphene as a coating and sensing device material could significantly enhance the acceptance of intracortical probes. However, such a thin monolayer of carbon atoms could be teared off during manipulation and insertion within the brain, and could also display degradation over time. In this work, we have investigated the ability to protect graphene with a natural, biocompatible and degradable polymeric film derivated from hyaluronic acid (HA). We demonstrate that HA-based coatings can be deposited over a wide range of substrates, including intracortical probes and graphene FET arrays without altering the underlying device material, its biocompatibility and sensitivity. Moreover, we show that this coating can be monitored <jats:italic>in situ</jats:italic> by quantifying the number of deposited charges with the G-FET arrays. The reported graphene functionalization offers promising alternatives for improving the acceptance of various neural interfaces.</jats:p>