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Caracterización del sistema del complemento e identificación de componentes del sistema inmune innato del yacaré overo (Caiman latirostris)

Pablo Ariel Siroski Mark Merchant Enrique Caviedes Vidal Marta Dolores Mudry Pablo Martín Beldoménico Hugo Héctor Ortega

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Resumen/Descripción – provisto por el repositorio digital
Crocodilians exhibit strongly marked social behaviors and responses to stressors that can trigger serious disputes between co-specifics, predators and, even, conflict with human activities. As a result, they could show trauma, serious injuries and the loss of members. Generally, these animals live in environments containing a high concentration of pathogenic microorganisms in both, natural and captive systems. In many cases, crocodilians tolerate these situations and generally, without showing signs of illness. In this work, it was found that Caiman latirostris plasma has antibacterial properties higher than human and chicken (Gallus gallus) plasma, suggesting that the complement system (CS) could be a cause of the inhibitory effects observed. Colorimetric assay was used to detect and characterize complement system. Moreover, the CS was used as an indicator of pesticide and ultraviolet radiation effects. Finally, we performed the detection and characterization of two enzymes involved in the immune system, DPPIV and PLA2, demonstrating that both of them have higher activities in caimans compared with other vertebrates and similar to other crocodilians studied. In conclusion, we might suggest that the caimans studied have efficient and well developed innate immune system that could resist the attack of some microorganisms. The powerful complement system would be one of the components mainly involved. Such resistance could be one of the reasons for the successful and longevity of crocodilians. This work should continue leading to the detection and characterization of the components of the complement system, taking into account a possible therapeutic application in the veterinary industry.
Palabras clave – provistas por el repositorio digital

Cocodrilians; Caiman latirostris; Caiman yacare; Immune system; Complement system; Hemolysis assay; DPPIV; PLA2; Cocodrilianos; Caiman yacaré; Sistema inmune; Sistema complemento; Prueba de hemólisis

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No requiere 2012 Biblioteca Virtual de la Universidad Nacional del Litoral (SNRD) acceso abierto

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Tipo de recurso:

tesis

Idiomas de la publicación

  • español castellano

País de edición

Argentina

Fecha de publicación