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<jats:title>Abstract</jats:title><jats:p>Genodermatoses are a complex and heterogeneous group of genetic skin disorders characterized by variable expression and clinical and genetic heterogeneity, rendering their diagnosis challenging. DNA‐based techniques, like whole‐exome sequencing, can establish a diagnosis in 50% of cases. RNA‐sequencing is emerging as an attractive tool that can obtain information regarding gene expression while integrating functional genomic data with regard to the interpretation of variants. This increases the diagnostic rate by an additional 10–15%. In the present review, we detail the clinical steps involved in the diagnosis of genodermatoses, as well as the current DNA‐based technologies available to clinicians. Herein, the intention is to facilitate a better understanding of the possibilities and limitations of these diagnostic technologies. In addition, this review could guide dermatologists through new emerging techniques, such as RNA‐sequencing and its applications to familiarizing them with future techniques. Currently, this multi‐omics approach is likely the best strategy designed to promote the diagnosis of patients with genodermatoses and discover new skin disease genes that could result in novel targeted therapies.</jats:p>