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Nimesulide has a variety of potentially novel, non-pain, effects some of which may be related to its known pharmacological actions relating to its anti-inflammatory effects. The effects of the drug on intracellular signalling pathways that regulate cell growth and other cellular controls may represent some unique sites of action of the drug.

Vector autoregressive (VAR) models are capable of capturing the dynamic structure of many time series variables. Impulse response functions are typically used to investigate the relationships between the variables included in such models. In this context the relevant impulses or innovations or shocks to be traced out in an impulse response analysis have to be specified by imposing appropriate identifying restrictions. Taking into account the cointegration structure of the variables offers interesting possibilities for imposing identifying restrictions. Therefore VAR models which explicitly take into account the cointegration structure of the variables, so-called vector error correction models, are considered. Specification, estimation and validation of reduced form vector error correction models is briefly outlined and imposing structural short- and long-run restrictions within these models is discussed.

Vector autoregressive (VAR) models are capable of capturing the dynamic structure of many time series variables. Impulse response functions are typically used to investigate the relationships between the variables included in such models. In this context the relevant impulses or innovations or shocks to be traced out in an impulse response analysis have to be specified by imposing appropriate identifying restrictions. Taking into account the cointegration structure of the variables offers interesting possibilities for imposing identifying restrictions. Therefore VAR models which explicitly take into account the cointegration structure of the variables, so-called vector error correction models, are considered. Specification, estimation and validation of reduced form vector error correction models is briefly outlined and imposing structural short- and long-run restrictions within these models is discussed.

Vector autoregressive (VAR) models are capable of capturing the dynamic structure of many time series variables. Impulse response functions are typically used to investigate the relationships between the variables included in such models. In this context the relevant impulses or innovations or shocks to be traced out in an impulse response analysis have to be specified by imposing appropriate identifying restrictions. Taking into account the cointegration structure of the variables offers interesting possibilities for imposing identifying restrictions. Therefore VAR models which explicitly take into account the cointegration structure of the variables, so-called vector error correction models, are considered. Specification, estimation and validation of reduced form vector error correction models is briefly outlined and imposing structural short- and long-run restrictions within these models is discussed.

In comparison with conventional NSAIDs (with COX-1 as well as COX-2 inhibitory effects) and the coxibs, nimesulide has been shown in a large number of studies to be equivalent to, or in some cases more effective in relieving pain and inflammatory signs and symptoms. Recent evidence suggesting that nimesulide may have fast onset of action in acute pain may be an advantage for the drug in certain clinical situations. Nimesulide has proven to be an effective drug in comparison with other NSAIDs including the coxibs.

Nimesulide, like other NSAIDs, exhibits adverse reactions in the major organ systems comprising the upper GI tract, liver, kidney, skin and immune systems. Noteworthy is the fact that this drug has relatively low occurrences of GI ulcers and bleeding, asthma and respiratory tract reactions and does not appear to have the cardiovascular reactions (congestive heart failure, myocardial infarction) that has been observed recently with the coxibs and some other NSAIDs.