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Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery

Resumen/Descripción – provisto por la editorial

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Palabras clave – provistas por la editorial

opioid receptors; neurokinin-1 receptor; peptide synthesis; receptor binding studies; functional assay; writhing test; tolerance; Leu-enkephalin; beta-arrestin; mu opioid receptor; delta opioid receptor; biased signaling; DADLE; ischemia; plasma stability; morphinan; BNTX; δ opioid receptor antagonist; 1H-NMR experiments; mechanism elucidation; peripheral antinociception; 14-methoxycodeine-6-O-sulfate; codeine-6-O-sulfate; opioid peptides and peptidomimetics; DAMGO; DALDA; [Dmt1]DALDA; KGOP01; binding; molecular docking; structure-activity relationships; β2-amino acids; β2-Homo-amino acids; µ-opioid receptor; opioid peptides; TAPP; racemic synthesis of β2-amino acids; peripheral µ-opioid receptors; analgesia; peripheral analgesic tolerance; dysbiosis; opioid; bifunctional ligands; (−)-N-phenethylnorhydromorphone analogs; [35S]GTPgammaS assay; forskolin-induced cAMP accumulation assays; β-arrestin recruitment assays; MOR and DOR agonists; respiratory depression; bias factor; molecular modeling & simulation; δ opioid receptor; NTI derivative; sulfonamide; inverse agonist; neutral antagonist; agonist; opioids; mu receptor; opioid side effects; biased agonism; partial agonism; zerumbone; chronic constriction injury (CCI); allodynia; hyperalgesia; potassium channels; over-the-counter drugs; misuse; abuse; opioid drugs; pharmacology; codeine; dihydrocodeine; loperamide; opioid peptide; macrocyclic tetrapeptide; multifunctional ligands; kappa opioid receptor; analgesics; opioid liabilities; μ opioid receptor; receptor model; biased ligands; dependence; pain therapy; neonatal opioid withdrawal syndrome; naltrexone; 6β-naltrexol; buprenorphine; G-protein bias; arrestin recruitment; respiration; mitragynine; heteromer; internalization; primary hippocampal culture; lysosomes; µ opioid receptor; molecular dynamics; docking; interaction fingerprints; biased agonists; SR-17018; PZM21; morphine; fentanyl; diphenethylamines; design and synthesis; structure–activity relationships; partial agonist; biased agonist; antagonist; binding affinity; selectivity; n/a

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Información

Tipo de recurso:

libros

ISBN electrónico

978-3-03650-047-8

País de edición

Suiza