Catálogo de publicaciones

Origins of Resistance to Toxic Agents contains the proceedings of the Symposium held in Washington, D.C. on March 25-27, 1954. Contributors theoretically explore the origins of drug resistance and related problems, based on the concept that the development of resistance to various toxic agents is associated with alterations and/or loss in enzyme proteins, and can explain the mutational and other processes.
This text is organized into five sections encompassing 25 chapters and begins with an overview of the evolutionary aspects of resistance to antibacterial agents, herbicides, and insecticides. The book then discusses spontaneous and induced mutations to drug resistance in Escherichia coli, along with the mechanism of drug resistance in protozoa and bacteria, the physiological aspects of insect resistance to insecticides, and the enzymatic detoxication of DDT. The next chapters focus on the origins of tolerance and addiction to drugs and the problem of alcoholism; biochemical effects of narcotics and alcohol administration; tolerance and physical dependence to narcotics; and resistance and dependence in cancer cells. The book concludes by analyzing the significance of protein configuration to the specificity of biological interaction.
This book is a valuable source of information for physicians, biochemists, pharmacologists, entomologists, plant physiologists, students of cancer, and those who are interested in the theory of the evolution of living matter.

Great effort has been undertaken to investigate potential geohazards in relation to the development of the Ormen Lange gas field offshore Mid-Norway.

The field is located in the scar left after the giant, tsunami-generating Storegga Slide, which occurred roughly 8200 years ago, and the slide risk has consequently received particular focus. The studies have been multi-disciplinary in character, and have involved a number of companies, universities, and research institutions. The results of the project led to a significant advance in the understanding of the Storegga Slide in particular, and submarine slope instability in general, and played an important role in the approval of field development by Norwegian authorities.

This book comprises 26 individual contributions representing the wide span of topics addressed in the project. The main scope is to provide a state-of-the-art report on geohazard investigations in a high latitude continental margin setting. Most of the data and results published in this book would not have reached beyond the confidential report stage unless the license partners of the Ormen Lange license had agreed that this information deserves a wider audience.

* Multidisciplinary and covers most themes treated in slope stability studies prior to the field development phase
* Provides a link between basic research and applied geohazard studies, with direct relevance for risk evaluation in relation to field development activities, such as pipeline design, drilling of wells, structure foundation etc.
* A state-of-the-art report on geohazard investigations in a high latitude continental margin setting in relation to field development activities

This authoritative and comprehensive book makes the reader familiar with the processes of bringing orphan drugs to the global market. There are between 5,000 and 7,000 rare diseases and the number of patients suffering from them is estimated to be more than 50 million in the US and Europe. Before the orphan drug legislation enacted in the US in 1983, there was a limited interest from industry to develop treatment for very small patient groups. One of the difficulties is, of course, that similar levels of investment are needed from a pharmaceutical company to bring a drug to the market for both small and large patient groups.

The journey from application of an orphan drug designation to a reimbursed market- approved drug is long and many obstacles occur during the journey.

After reading the book, readers will: Understand who the players/stakeholders are in the rare orphan disease field and their specific needs and concerns: patients and patient organizations, researchers and treating physicians within the field, industry, regulatory and reimbursement bodies* Understand the strong partnership between the different players and the various initiatives to improve and increase access to treatment for patients; minimizing the gap between numbers of known diseases, orphan designations, approved drugs and paid drugs.

The book also provides short practical case stories from patients and researchers, as well as representatives from industry and authorities on the challenges they came across in developing orphan drugs or getting access to orphan drugs.

• A comprehensive overview of strategy, key activities and considerations of how to bring an orphan drug from concept to the market and make it available to patients
• A source of updated information, news and trends for those who are already active in this fast-evolving field
• Covers the global definitions and the criteria for getting an orphan drug designation in, for example, the US and Europe

Capturing the latest thinking for the evaluation and treatment of dentofacial deformities,  Orthognathic Surgery: Principles and Practice, covers the basic principles and concepts of dentofacial deformities along with planning, surgical techniques, surgical complications, classic patterns, and clinical presentations. Over 5,000 clinical photos and detailed art make this a valuable reference for clinical orthodontists, craniofacial surgeons, oral and maxillofacial surgeons, and residents in training.

"It is an excellent all round educational source for any practitioner and the owner of this text is unlikely to need any other textbook on orthognathic surgery." Reviewed by J Murphy, British Dental Journal  Jan 2015.

"..will be of interest to all orthodontic professionals who deal with the specialty of orthognathic surgery." Reviewed by Antonio M. Miotti on behalf of European Journal of Orthodontics, July 2015

Quickly reference the answers you need to the most important clinical questions in orthopedics with Orthopedic Secrets. Fully updated throughout, this classic medical reference book covers the entire range of essential topics in orthopedics, organized by subspecialty, for rapid access to the knowledge you need for success both in practice and on board and recertification exams.