Catálogo de publicaciones

Sequenced biological macromolecules have revitalized systematic studies of evolutionary history. Molecular Systematics of Fishes is the first authoritative overview of the theory and application of these sequencing data to fishes. This volume explores the phylogeny of fishes at multiple taxonomic levels, uses methods of analysis of molecular data that apply both within and between fish populations, and employs molecule-based phylogenies to address broader questions of evolution. Targeted readers include ichthyologists, marine scientists, and all students, faculty, and researchers interested in fish evolution and ecology and vertebrate systematics.

Key Features
* Focuses on the phylogeny and evolutionary biology of fishes
* Contains phylogenies of fishes at multiple taxonomic levels
* Applies molecule-based phylogenies to broader questions of evolution
* Includes methods for critique of analysis of molecular data

Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.

• Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases
• Provides a “drug discovery” application oriented perspective, evaluating targets and candidates for their overall therapeutic potential
• Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development
• Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area
• Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets

Jury Award for Enology, 2012, OIV: International Organization of Vine and Wine

Molecular Wine Microbiology features rigorous scientific content written at a level comprehensible for wine professionals as well as advanced students. It includes information on production and spoilage issues, the microbial groups relevant for wine production and microbial wine safety.

Microbiology has long been recognized as a key tool in studying wine production, however only recently have wine microbiology studies been addressed at a molecular level, increasing the understanding of how microbiology impacts not only the flavor quality of the wine, but also its safety. Understanding, at a molecular level, how a starter culture can impact ethanol, glycerol, volatile phenols, mannoproteins, biogenic amines or ochratoxin A of a wine are just some of the core points that must be considered in order to achieve maximium consumer acceptability while addressing safety concerns during processing and storage. While other books offer insights into the technological aspects of enology, this book is written by expert microbiologists, who explore the positive and negative impacts of gene function in the production of wine, from a microbiological point of view.

• Winner of the 2012 Jury Award in Enology from the International Organisation of Vine and Wine
• Presents the most current methods of studying the microbiology of wine
• Includes latest identification and typing methods, reducing identification time from days and weeks to minutes and hours
• Provides important knowledge about the impact of microbiological factors at the molecular level for reduction of wine spoilage and increased wine quality and safety

Molecularly Imprinted Catalysts: Principle, Synthesis, and Applications is the first book of its kind to provide an in-depth overview of molecularly imprinted catalysts and selective catalysis, including technical details, principles of selective catalysis, preparation processes, the catalytically active polymers themselves, and important progress made in this field. It serves as an important reference for scientists, students, and researchers who are working in the areas of molecular imprinting, catalysis, molecular recognition, materials science, biotechnology, and nanotechnology.
Comprising a diverse group of experts from prestigious universities and industries across the world, the contributors to this book provide access to the latest knowledge and eye-catching achievements in the field, and an understanding of what progress has been made and to what extent it is being advanced in industry.

• The first book in the field on molecularly imprinted catalysts (MIPs)
• Provides a systematic background to selective catalysis, especially the basic concepts and key principles of the different MIP-based catalysts
• Features state-of-the art presentation of preparation methods and applications of MIPs
• Written by scientists from prestigious universities and industries across the world, and edited by veteran researchers in molecular imprinting and selective catalysis

Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies.  Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin.

• Covers the role of mTOR by internationally recognized expert contributors in the field.
• Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels.
• Includes analysis of the role of mTOR and in both health and disease.
• Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.