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Metabolic Inhibitors: A Comprehensive Treatise, Volume III reviews developments in metabolic and enzyme inhibition. With contributions by investigators experienced in their respective fields, the book explores metabolic processes or systems and covers topics ranging from membrane transport to immunization; gene activity; DNA, RNA, and protein syntheses; photosynthesis; lipid metabolism; and blood clotting.
Organized into 12 chapters, this volume begins with an overview of transport reactions and their inhibition, emphasizing inhibitors of ATPase including cations, substrates, and products. Some chapters deal with inhibitors, such as antibiotics; polypeptide and protein hormones; modified transfer RNAs; and oligonucleotides. Other chapters discuss inhibitors of immune reactions; animal virus replication; plant viruses and mycoplasma; and isozymes. An account of genetic deletions is also given. Finally, the book considers molecules that act as repressors and derepressors of gene activity.
This book will be beneficial to biochemists and medical research workers, as well as to virologists, microbiologists, plant physiologists, and agronomists.

Metabolic Inhibitors: A Comprehensive Treatise, Volume IV reviews developments in studies of inhibition of metabolic and enzymic processes ranging from photosynthesis and blood clotting to protein synthesis, fatty acid metabolism, and phospholipid metabolism. The book also explores the inhibition of specific enzyme reactions, such as amino acid activation, amino acid hydroxylation, and cyclic AMP formation.
Organized into nine chapters, this volume begins with an overview of allosteric inhibition and inhibitors, and then discusses amino acid hydroxylase inhibitors. The reader is also introduced to inhibitors and activators of enzymes that regulate the cellular concentration of cyclic AMP. In particular, the book describes the role of lipids in the activation of adenyl cyclase by hormones; modification of adenyl cyclase in various physiological and pathological conditions; and synthesis of glycerophosphatides as well as phospho- and glycosphingolipids.
This book is a valuable source of information for biochemists and medical research workers as well as virologists, microbiologists, plant physiologists, and agronomists.

Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches.

In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics.

In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream.

• Translates the conjunction of new surgical tools for intraoperative, real-time, metabolite evaluation and direct analysis of biofluid samples into novel options for augmented clinical decision-making
• Discusses longitudinal sampling from individual patients for stratified medicine
• Covers high resolution analytical spectroscopy and sophisticated computational modelling for prediction of adverse reactions in critical care scenarios, prognostic evaluation of cancer from biofluidism, and prognostic prediction of metabolism or response of patients to pharmaceutical interventions
• Encapsulates recent technology options for broader population profiling considerations, in particular, the metabolome-wide association studies (MWAS) that aid the translational researcher in identifying metabolic patterns associated with disease
• Foreword written by Professor Dame Sally Davies who is the Chief Medical Officer for England

Metabolic Pathways, Third Edition: Metabolic Transport, Volume VI investigates membrane transport and its role in cell physiology. The book describes the transport of solutes across membranes and of carbohydrates in bacterial cells, as well as other processes such as cellular transport of water, amino acid transport in microorganisms, proton transport, and calcium transport by the sarcoplasmic reticulum.
Organized into 16 chapters, this volume begins with an overview of the kinetics of transport, emphasizing the monovalent carrier mechanism of facilitated diffusion and active transport involving monovalent carriers. The book then introduces the reader to the transport of various ligands by animal cells or microorganisms; transport by intracellular organelles; and the role of sodium pump in animal tissues in the regulation of cellular metabolism and function. The book also examines the transport of biogenic amines and some mechanisms involved in the control of transport. A few examples of the role of transport in subserving other cellular processes are presented.
This book is a valuable source of information for workers in the transport field, along with biologists whose research interests overlap with the transport field.

The Bacteria: A Treatise on Structure and Function, Volume II: Metabolism deals with the gross metabolism of microorganisms in energy liberating reactions and pathways. The book investigates energy-yielding metabolism in bacteria; fermentation; terminal oxidation and its cyclic mechanisms; electron transport; and bacterial photosynthesis and luminescence.
This volume is organized into 11 chapters and begins with a discussion of problems of energy metabolism that apply to all cells and unicellular organisms. The book also explains the biologically available energy released by glycolysis, oxidation, and light to chemical bond transformation and its quantitative relationships to whole cell requirements. The reader is then introduced to the fermentation of carbohydrates and related compounds, particularly the pathways of carbon and the role of hydrogen acceptors in fermentation, along with the decomposition of nitrogenous compounds such as amino acids, purines, and pyrimidines. The remaining chapters focus on the cyclic mechanisms for the synthesis of cellular components and for the yield of energy by oxidation. The breakdown of high molecular weight substances such as polysaccharides and bacterial cell walls is also explained. The chapters discuss as well the mechanisms of electron transport in microbes. The book concludes by exploring the physiological aspects of bacterial luminescence as well as the taxonomy and evolution of luminous bacteria.
This book is a valuable resource for biochemists, microbiologists, bacteriologists, investigators, and students interested in the metabolic processes affecting bacteria.

The Physiology of Crustacea, Volume I: Metabolism and Growth deals with the physiological aspects of metabolism and growth in hundreds of species and higher taxa of Crustacea. The book explores processes related to the morphology and development of crustaceans, from blood chemistry to feeding and nutrition, digestion, excretion, molting, autotomy, and regeneration.
This volume is organized into 17 chapters and begins with an overview of crustacean biology and systematics as well as ontogeny and phylogeny. The book then discusses the metabolic requirements of crustacean respiration, the mechanisms of gas exchange, and respiratory transport. The next chapters focus on the biochemistry of animal pigments such as hemoglobin and melanin and the crustacean blood chemistry, blood flow, heart function, feeding mechanisms, and vitamin contents. The book also discusses the digestive system of crustaceans, along with osmotic and ionic regulation; the excretory system; the link between ecology and metabolism; and sex differentiation in Crustacea.
This book is written primarily for biologists, physiologists, and zoologists, as well as advanced students and research workers who are interested in problems of comparative physiology.

Metabolomics is a multidisciplinary science used to understand the ways in which nutrients from food are used in the body and how this can be optimised and targeted at specific nutritional needs. Metabolomics as a Tool in Nutrition Research provides a review of the uses of metabolomics in nutritional research. Chapters cover the most important aspects of the topic such as analysis techniques, bioinformatics and integration with other ‘omic’ sciences such as proteomics and genomics. The final chapters look at the impact of exercise on metabolomic profiles and future trends in metabolomics for nutrition research.

Metabolomics enables valuable information about the biochemical composition of foods to be rapidly obtained. Since the biochemical profile of food largely determines key food properties such as flavour and shelf life, the information gained using metabolomics-based methods will enable greater control of food quality and also help to determine the relationship between diet and health. Metabolomics in food and nutrition provides an overview of their current and potential use in the food industry.

Part one reviews equipment, methods and data interpretation in metabolomics including the use of nuclear magnetic resonance (NMR), statistical methods in metabolomics, and metabolic reconstruction databases and their application to metabolomics research. Part two explores applications of metabolomics in humans, plants and food. Chapters discuss metabolomics in nutrition, human samples for health assessments, and current methods for the analysis of human milk oligosaccharides (HMOs) and their novel applications. Further chapters highlight metabolomic analysis of plants and crops, metabolomics for the safety assessment of genetically modified (GM) crops, and applications of metabolomics in food science including food composition and quality, sensory and nutritional attributes.

With its distinguished editors and team of expert contributors, Metabolomics in food and nutrition is a technical resource for industrial researchers in the food and nutrition sectors interested in the potential of metabolomics methods and academics and postgraduate students working in the area.

• Provides an overview of the current and potential future use of metabolomics in the food industry
• Chapters focus on key applications and review the analytical methods used and the bioinformatics techniques involved in processing the results
• Discusses metabolomics in nutrition, human samples for health assessments, and current methods for the analysis of human milk oligosaccharides (HMOs) and their novel applications