Catálogo de publicaciones

Human Chromosome Methodology serves as an authoritative guide to cytogenetic techniques. This book presents each phase of laboratory work from preparation of materials for the X and Y bodies to application of other laboratory techniques including chromosome identification, autoradiography, and dermatoglyphics. The text also describes the structure and molecular organization of chromosomes and the advances in the automation of chromosome analysis. It provides a thorough review of the clinical manifestations of chromosome disorders.

Organized into 13 chapters, the book presents the illustrated and diagrammatic examples and discussions of the subject matter and detailed tables and charts for learning efficiency. It also provides outlined presentation of cytogenetic procedures and notes and comments for each procedure that will assist readers in erroneous work phases. Moreover, it gives thorough lists of references in each chapter for further reading.

This reference will be useful for research professionals, lecturers, genetics and molecular biology students, and members of the medical profession involved in genetics.

Human Fatigue Risk Management: Improving Safety in the Chemical Processing Industry teaches users everything they need to know to mitigate the risk of fatigued workers in a plant or refinery. As human fatigue has been directly linked to several major disasters, the book explores the API RP 755 guidelines that were released to reduce these types of incidents. This book will help users follow API RP 755 and/or implement a fatigue risk management system in their organization.

Susan Murray, a recognized expert in the field of sleep deprivation and its relation to high hazard industries, has written this book to be useful for HSE managers, plant and project managers, occupational safety professionals, and engineers and managers in the chemical processing industry. As scheduling of shifts is an important factor in reducing fatigue and accident rates, users will learn the benefits of more frequent staff rotation and how to implement an ideal scheduling plan.

The book goes beyond API RP 755, offering more detailed understanding of why certain measures for managing fatigue are beneficial to a company, including examples of how theory can be put into practice. It is a simple, digestible book for managers who are interested in addressing human factor issues at their workplace in order to raise safety standards.

• Covers sleep, sleep disorders, and the consequences of fatigue as related to high-hazard industries
• Helps improve safety standards at the plant level
• Provides information on how to comply with API RP 755 and related OSHA 29CFR1910 articles
• Relates fatigue and human performance to accidents, helping readers make a case for implementing a human fatigue risk management policy, which, in turn, prevents loss of property and life

In the nearly 60 years since Watson and Crick proposed the double helical structure of DNA, the molecule of heredity, waves of discoveries have made genetics the most thrilling field in the sciences.  The study of genes and genomics today explores all aspects of the life with relevance in the lab, in the doctor’s office, in the courtroom and even in social relationships.   In this helpful guidebook, one of the most respected and accomplished human geneticists of our time communicates the importance of genes and genomics studies in all aspects of life.  With the use of core concepts and the integration of extensive references, this book provides students and professionals alike with the most in-depth view of the current state of the science and  its relevance across disciplines.

• Bridges the gap between basic human genetic understanding and one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease.
• Includes the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more
• Explores ethical, legal, regulatory and economic aspects of genomics in medicine.
• Integrates historical (classical) genetics approach with the latest discoveries in structural and functional genomics

Offering a study of biological, biomedical and biocultural approaches, the second edition of Human Growth and Development is a valued resource for researchers, professors and graduate students across the interdisciplinary area of human development. With timely chapters on obesity, diet / lifestyle, and genetics, this edition is the only publication offering a biological, biomedical and biocultural approach. The second edition of Human Growth and Development includes contributions from the well-known experts in the field and is the most reputable, comprehensive resource available.

• New chapters discussing genomics and epigenetics, developmental origins, body proportions and health and the brain and neurological development.
• Presented in the form of lectures to facilitate student programming
• Updated content highlighting the latest research on the relationship between early growth and later (adult) outcomes: the developmental origins of health and disease.

Completely revised and updated, Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition, delivers a contemporary and thorough review of HHV-6, beginning with foundational explorations of classification, molecular biology, and chromosomal integration of the virus, through to clinical details, including pathologic features of infection, and clinical effects on various organ systems. The work now includes coverage of HHV-7, a virus that remains underestimated in transplant reactivation, seizures, and encephalitis.

The book examines the role of HHV-6 in myriad diseases, including cognitive disorders following bone marrow transplant, mesial temporal lobe epilepsy, multiple sclerosis, autoimmune disease, encephalitis, Hodgkin's disease lymphoma (HHV-6B), and glioma (HHV-6A). Descriptions of current and novel molecular and serological diagnostic assays, along with detailed protocols, are included to aid researchers and clinicians in discriminating potential false positives originating from chromosomally integrated HHV-6, and in differentiating between active and latent infection.

Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition is a valuable reference for both clinical and basic scientists, including epidemiologists, virologists, practicing clinicians, infectious disease specialists, pathologists, and all scientists entering the field of herpes virus research. The work is a practical and thorough resource for a foundational understanding of HHV-6 and HHV-7, while providing a cutting-edge translational and clinical reference to those looking to understand and diagnose associated viral diseases.

• Delivers the latest molecular diagnostic tests, the present-day gold standard for monitoring HHV-6
• Provides expert analysis of T-cell immune response against HHV-6
• Presents tools for differential diagnosis in HHV-6 viral infections
• Includes new information on the previously-largely-unknown biological consequences of ciHHV-6
• Offers coverage of new discoveries relating to HHV-7

Human Lymphokines: The Biological Immune Response Modifiers is a collection of papers presented at the Third International Symposium on Human Lymphokines held on October 15-17, 1981 at the Wadley Institutes of Molecular Medicine in Dallas, Texas. Contributors explore the role of human lymphokines in immune responses and their applications in immunotherapy. The focus is on lymphokines that have either entered clinical trials or are nearing clinical evaluation. Some of the activities of possible immediate significance, such as Glia cell stimulating factor and polyclonal B-cell activator, are also described.
This volume is organized into six sections encompassing 56 chapters and begins with an overview of assay systems, touching on topics such as the activation of macrophages by interferon to produce plasminogen and macrophage activation by lymphokine factors. The next sections turn to the production, purification, and biological and chemical characterization of lymphokines. The discussion then shifts to the mechanisms of action of lymphokines in vitro and the use of animal models in lymphokine investigations, including lymphokine fractions in a mouse tumor model and enhancement of natural killing activity by different types of interferon. A great deal of emphasis is placed on macrophage migration inhibitory factor, lymphotoxins, gamma interferon, and interleukins. The book concludes with chapters devoted to the immunoregulatory effects of lymphokines and clinical studies.