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Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by  pharmacogenomics and stratified medicine details.

Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development.

• Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise
• Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics,  pharmacokinetics and pharmacodynamics
• Covers newer technologies– next generation sequencing, proteomics, metabolomics
• Provides information on animal models, lymphoblastoid cell lines, stem cells
• Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues
• Includes chapters on the global implications of pharmacogenomics

This book covers all aspects of physical vapor deposition (PVD) process technology from the characterizing and preparing the substrate material, through deposition processing and film characterization, to post-deposition processing. The emphasis of the book is on the aspects of the process flow that are critical to economical deposition of films that can meet the required performance specifications.

The book covers subjects seldom treated in the literature: substrate characterization, adhesion, cleaning and the processing. The book also covers the widely discussed subjects of vacuum technology and the fundamentals of individual deposition processes. However, the author uniquely relates these topics to the practical issues that arise in PVD processing, such as contamination control and film growth effects, which are also rarely discussed in the literature. In bringing these subjects together in one book, the reader can understand the interrelationship between various aspects of the film deposition processing and the resulting film properties. The author draws upon his long experience with developing PVD processes and troubleshooting the processes in the manufacturing environment, to provide useful hints for not only avoiding problems, but also for solving problems when they arise. He uses actual experiences, called "war stories", to emphasize certain points. Special formatting of the text allows a reader who is already knowledgeable in the subject to scan through a section and find discussions that are of particular interest. The author has tried to make the subject index as useful as possible so that the reader can rapidly go to sections of particular interest. Extensive references allow the reader to pursue subjects in greater detail if desired.

The book is intended to be both an introduction for those who are new to the field and a valuable resource to those already in the field. The discussion of transferring technology between R&D and manufacturing provided in Appendix 1, will be of special interest to the manager or engineer responsible for moving a PVD product and process from R&D into production. Appendix 2 has an extensive listing of periodical publications and professional societies that relate to PVD processing. The extensive Glossary of Terms and Acronyms provided in Appendix 3 will be of particular use to students and to those not fully conversant with the terminology of PVD processing or with the English language.

This new Handbook provides a series of reference guides to cleaner production methods, technologies, and practices for key industry sectors.

Each volume covers, for each industry sector: * the manufacturing technologies * waste management * pollution * methods for estimating and reporting emissions * treatment and control technologies * worker and community health risk exposures * cost data for pollution management * cleaner production and prevention alternatives Best Practices in the Wood and Paper Industries provides an overview of the forestry, wood preserving, pulp and paper industries and identifies the key environmental aspects, supported by case studies of major incidents. It provides general explanations of the major unit operations and processes in pulp and paper mills and wood treating plants, covering new trends alongside traditional methods. The environmental issues regarding air, water and solid waste are all addressed, identifying all US plants and their TRI data, and the authors provide calculation methods for properly accounting for air emissions and P2 practices to reduce them.

• Provides guidelines on cleaner production and pollution prevention practices for improving overall environmental performance
• Discusses emerging technologies and processes for cleaner air
• Contains an Inventory of Chemical Toxicity Properties

This new Handbook provides a series of reference guides to cleaner production methods, technologies, and practices for key industry sectors.

Each volume covers, for each industry sector: * the manufacturing technologies * waste management * pollution * methods for estimating and reporting emissions * treatment and control technologies * worker and community health risk exposures * cost data for pollution management * cleaner production and prevention alternatives Best Practices in The Petroleum Industry provides an overview of refineries and gas plant operations and identifies the key Environmental Aspects, supported by case studies of major incidents that resulted in catastrophic releases of oil and refined products, and a critical assessment of the methodology and calculation procedures that the industry relies on in preparing emissions inventories.  The authors offer alternative approaches to providing more accurate emissions estimates, and guidelines on cleaner production and pollution prevention practices for improving overall environmental performance.

• Overview of the key Environmental Aspects of gas plant operations and refineries
• Case studies of major incidents that resulted in catastrophic releases of oil and refined products, including the Santa Barbara oil spill of 1969 and the EXXON Valdez incident
• Provides guidelines on cleaner production and pollution prevention practices for improving overall environmental performance

The Handbook of Cleaner Production comprises a series of reference guides to cleaner production methods, technologies, and practices for key industry sectors.

Each volume covers, for each industry sector: * manufacturing technologies * waste management * pollution control and remediation * methods for estimating and reporting emissions * treatment and control technologies * health risk exposures for workers and the wider community * cost data for pollution management * cleaner production and prevention options

* safe chemical handling practices Best Practices in the Agrochemical Industry includes coverage of pollution of drinking water (atrazine, trichloropropane and DBCP and the risks associated with them, such as miscarriages and infertility), pesticide residues in food, a case study of worker pesticide exposure and cancer, contaminants in organic food, etc.

Extensive data is provided regarding regulatory limits for exposure to pesticides according to EPA, NIOSH, OSHA, WHO and ACGIH.

* Coverage of agrochemical residues and their health impacts, and mitigation strategies

* Includes extensive data tables covering USA and international regulatory requirements (EPA, NIOSH, OSHA, WHO and ACGIH)

* Details safer manufacturing processes and procedures to limit pollution

Handbook of Polymers, Second Edition, presents normalized, up-to-date polymer data in a consistent and easily referenceable layout. This new edition represents an update of the available data, including new values for many commercially available products, verification of existing data, and removal of older data where it is no longer useful.

The book includes data on all major polymeric materials used by the plastics industry and all branches of the chemical industry, as well as specialty polymers used in the electronics, pharmaceutical, medical, and space fields. The entire scope of the data is divided into sections to make data comparison and search easy, including synthesis, physical, mechanical, and rheological properties, chemical resistance, toxicity and environmental impact, and more.

The data enables engineers and materials scientists to solve practical problems, be that in applications, research and development, or legislation. The most current grades of materials have been selected to provide readers with information that is characteristic of currently available products.

• Includes practical data on the most widely used polymers for engineers and materials scientists in design, manufacture, and applications research
• Presents data on polymer synthesis, properties, chemical resistance, processing, and their related environmental impacts
• Provides a comprehensive update to the data, including new information and the verification of existing datasets

Process Algebra is a formal description technique for complex computer systems, especially those involving communicating, concurrently executing components. It is a subject that concurrently touches many topic areas of computer science and discrete math, including system design notations, logic, concurrency theory, specification and verification, operational semantics, algorithms, complexity theory, and, of course, algebra.
This Handbook documents the fate of process algebra since its inception in the late 1970's to the present. It is intended to serve as a reference source for researchers, students, and system designers and engineers interested in either the theory of process algebra or in learning what process algebra brings to the table as a formal system description and verification technique. The Handbook is divided into six parts spanning a total of 19 self-contained Chapters.
The organization is as follows. Part 1, consisting of four chapters, covers a broad swath of the basic theory of process algebra. Part 2 contains two chapters devoted to the sub-specialization of process algebra known as finite-state processes, while the three chapters of Part 3 look at infinite-state processes, value-passing processes and mobile processes in particular. Part 4, also three chapters in length, explores several extensions to process algebra including real-time, probability and priority. The four chapters of Part 5 examine non-interleaving process algebras, while Part 6's three chapters address process-algebra tools and applications.

Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more.