Catálogo de publicaciones

Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline.

It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease.

• Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia
• Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline
• Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities
• Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Genetic and Genomic Resources For Cereals Improvement is the first book to bring together the latest available genetic resources and genomics to facilitate the identification of specific germplasm, trait mapping, and allele mining that are needed to more effectively develop biotic and abiotic-stress-resistant grains.

As grain cereals, including rice, wheat, maize, barley, sorghum, and millets constitute the bulk of global diets, both of vegetarian and non-vegetarian, there is a greater need for further genetic improvement, breeding, and plant genetic resources to secure the future food supply.

This book is an invaluable resource for researchers, crop biologists, and students working with crop development and the changes in environmental climate that have had significant impact on crop production. It includes the latest information on tactics that ensure that environmentally robust genes and crops resilient to climate change are identified and preserved.

• Provides a single-volume resource on the global research work on grain cereals genetics and genomics
• Presents information for effectively managing and utilizing the genetic resources of this core food supply source
• Includes coverage of rice, wheat, maize, barley, sorghum, and pearl, finger and foxtail millets

Grain legumes, including common-bean, chickpea, pigeonpea, pea, cowpea, lentil and others, form important constituents of global diets, both vegetarian and non-vegetarian. Despite this significant role, global production has increased only marginally in the past 50 years. The slow production growth, along with a rising human population and improved buying capacity has substantially reduced the per capita availability of food legumes. Changes in environmental climate have also had significant impact on production, creating a need to identify stable donors among genetic resources for environmentally robust genes and designing crops resilient to climate change.

Genetic and Genomic Resources of Grain Legume Improvement is the first book to bring together the latest resources in plant genetics and genomics to facilitate the identification of specific germplasm, trait mapping and allele mining to more effectively develop biotic and abiotic-stress-resistant grains. This book will be an invaluable resource for researchers, crop biologists and students working with crop development.

• Explores origin, distribution and diversity of grain legumes
• Presents information on germplasm collection, evaluation and maintenance
• Offers insight into pre-breeding/germplasm enhancement efforts
• Integrates genomic and genetic resources in crop improvement
• Internationally contributed work

Genetic Control of Immune Responsiveness: Relationship to Disease Susceptibility documents the proceedings of an international conference held at Brook Lodge, Augusta, Michigan, May 8-10, 1972. It brings together the detailed experimental evidence on the mechanism of action of specific immune response genes, and shows how the two major classes of immune response genes affect our understanding of basic immunology and antibody formation on the one hand, and of host factors determining disease susceptibility on the other.
The book is organized into seven parts that correspond to the seven sessions of the conference. Part I presents a session on how the study of the genetic control of immune responses in guinea pigs and mice has contributed to the development of T cell immunology. Part II presents a session on genetic fine structure of the major (H-2) histocompatibility complex in the mouse. Part III presents a session dealing with the association between the production of homogeneous antibody, or of idiotypic antibody, and immunoglobulin allotypes. Part IV presents a session on the relationship between histocompatibility-linked and allotype-linked immune response genes and antigen-specific receptors on T and B cells. Part V presents a session on animal models of multigenic control of susceptibility to disease. Part VI presents a session on the associations between HL-A type and specific disease entities. Finally, Part VII provides a commentary on the ideas and concepts emerging from the three days of free-ranging discussion.

Genetic Control of Insect Pests focuses on laboratory and field trials of genetic control methods of insects, which entails the use of insects to control themselves. It particularly describes species-specific and non-polluting genetic methods that have the advantage over most other methods of being efficient when the target insect is in low density, as the released insects have the capacity to search out the wild populations.
Composed of nine chapters, the core parts of the book cover the mass-rearing, sterilization, and release of populations in the hope that these will mate with wild populations, leading to fertility reduction and population elimination. The book also examines techniques that use naturally existing population incompatibilities and techniques, which can result in population replacement rather than eradication with the intention to render such replacement populations harmless beforehand by genetic manipulation.
This book is a valuable source of information for those who are searching for biological alternatives of insect pests control.

Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies.

For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown.

• Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission
• Provides a summary of the concepts of both population suppression and population replacement
• Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies

Genetic Control of Natural Resistance to Infection and Malignancy is a collection of papers presented at the 1980 Proceedings of an International Symposium of the Canadian Society for Immunology held in Montreal, Quebec. It provides information about the different models of genetic resistance to various diseases.
The book offers an overview of the genetic determination of the susceptibility or resistance to infection and malignancy. It also discusses the importance of genetic resistance not only in the first-line observation of infections and tumors, but also in chemotherapy and immunotherapy. It then explains the genetic control of resistance to parasitic, bacterial, and virus infections, as well as to tumor growth. It further discusses the genetic control of macrophage differentiation and function.

Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders.

The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias.

• Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases
• Teaches the essentials of the genetic basis of disease in each major endocrine organ system
• Offers expert advice from genetic counselors on how to use genetic information in counseling patients
• Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing