Catálogo de publicaciones

The Ore Minerals Under the Microscope: An Optical Guide, Second Edition, is a very detailed color atlas for ore/opaque minerals (ore microscopy), with a main emphasis on name and synonyms, short descriptions, mineral groups, chemical compositions, information on major formation environments, optical data, reflection color/shade comparison with four common/standard minerals of a similar color or grey shade, and up to five high-quality photos for each mineral with scale.

In addition, the atlas contains a compilation from some of the prominent publications in the field of ore microscopy presented on a list of 431 minerals.

• Concise, full-color pictorial reference for scientists and geologists
• Explains how to describe and identify microscopic samples of minerals
• Draws material from prominent literature yielding more than 400 different minerals

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows the reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition reflects significant changes in the process of drug design over the last decade. It preserves the successful approach of the previous editions while including significant changes in format and coverage.

New to this edition:

• Updates to all chapters, including new examples and references
• Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book
• Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry
• Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant
• Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis
• Chapter 5 (Enzyme Inhibition and Inactivation): New case histories:
• for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib
• for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid
• for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin
• Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples
• Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites
• Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates