Catálogo de publicaciones

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by  pharmacogenomics and stratified medicine details.

Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development.

• Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise
• Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics,  pharmacokinetics and pharmacodynamics
• Covers newer technologies– next generation sequencing, proteomics, metabolomics
• Provides information on animal models, lymphoblastoid cell lines, stem cells
• Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues
• Includes chapters on the global implications of pharmacogenomics

This new Handbook provides a series of reference guides to cleaner production methods, technologies, and practices for key industry sectors.

Each volume covers, for each industry sector: * the manufacturing technologies * waste management * pollution * methods for estimating and reporting emissions * treatment and control technologies * worker and community health risk exposures * cost data for pollution management * cleaner production and prevention alternatives Best Practices in the Wood and Paper Industries provides an overview of the forestry, wood preserving, pulp and paper industries and identifies the key environmental aspects, supported by case studies of major incidents. It provides general explanations of the major unit operations and processes in pulp and paper mills and wood treating plants, covering new trends alongside traditional methods. The environmental issues regarding air, water and solid waste are all addressed, identifying all US plants and their TRI data, and the authors provide calculation methods for properly accounting for air emissions and P2 practices to reduce them.

• Provides guidelines on cleaner production and pollution prevention practices for improving overall environmental performance
• Discusses emerging technologies and processes for cleaner air
• Contains an Inventory of Chemical Toxicity Properties

Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more.

New discoveries in the field of stem cells increasingly dominate the news and scientific literature revealing an avalanche of new knowledge and research tools that are producing therapies for cancer, heart disease, diabetes, and a wide variety of other diseases that afflict humanity. The Handbook of Stem Cells integrates this exciting area of life science, combining in two volumes the requisites for a general understanding of adult and embryonic stem cells. Organized in two volumes entitled Pluripotent Stem Cells and Cell Biology and Adult and Fetal Stem Cells, this work contains contributions from the world’s experts in stem cell research to provide a description of the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations as well as a the latest information of what is known about each specific organ system.

• Provides comprehensive coverage on this highly topical subject
• Contains contributions by the foremost authorities and premiere names in the field of stem cell research
• Companion website - http://booksite.elsevier.com/9780123859426/ - contains over 250 color figures in presentation format

2013 PROSE Awards - Honorable Mention, Single Volume Reference Works: Association of American Publishers, Handbook of Systems Biology

PROSE Award 2013, Reference Work, Single Volume /Science, Honorable Mention, American Association of Publishers

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics.

• 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards
• Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines
• Includes the latest research developments in human and animal models to assist with translational research
• Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems.

The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.

• Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition
• Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline
• Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline
• Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering
• New chapters on genetics, evolutionary biology, bone aging, and epigenetic control
• Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions