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Respirology

Resumen/Descripción – provisto por la editorial en inglés

Respirology is a journal of international standing, publishing peer-reviewed articles of scientific excellence in clinical and experimental respiratory biology and disease and its related fields of research including thoracic surgery,interventional pulmonology, immunology, intensive and critical care, epidemiology, cell and molecular biology, pathology, pharmacology, physiology and paediatric respiratory medicine.
The Journal aims to encourage the international exchange of results and encourages papers in the following categories: Original Articles, Editorials, Reviews, Scientific Letters, Clinical Notes and Correspondences.

Palabras clave – provistas por la editorial

respirology; airways; asthma; breathing; cancer; circulation; infectious disease; lung disease; pulm

Disponibilidad

Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde ene. 1996 / hasta dic. 2023	Wiley Online Library

Información

Tipo de recurso:

revistas

ISSN impreso

1323-7799

ISSN electrónico

1440-1843

Editor responsable

John Wiley & Sons, Inc. (WILEY)

País de edición

Australia

Fecha de publicación

1996-

Cobertura temática

Medicina clínica

Tabla de contenidos

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doi: 10.1111/resp.14611

Clinical features and outcomes of small airway disease in ANCA‐associated vasculitis

Peining Zhou; Li Gao; Zhiying Li; Chengli Que; Haichao Li; Jing Ma; Guangfa Wang

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Objective</jats:title><jats:p>To clarify the prevalence, features and outcomes of small airway disease (SAD) in a Chinese cohort with antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV) related pulmonary involvement.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>SAD was recorded when the manifestations of either centrilobular nodules or air trapping were observed according to CT scans, except for infection or other airway‐related comorbidities. Baseline and follow‐up data were collected retrospectively.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of the 359 newly diagnosed AAV patients with pulmonary involvement, 92 (25.6%) had SAD, including 79 (85.9%) cases of anti‐MPO‐ANCA positive, 9 (9.8%) cases of anti‐PR3‐ANCA positive and 2 (2.2%) cases of double positive. Patients with SAD were more likely to be younger, female, non‐smokers, have more ear–nose–throat (ENT) involvement, and have higher baseline Birmingham Vasculitis Activity Score (BVAS) compared to patients without SAD. Several AAV‐related SAD patients have improved lung function and CT scans after immunosuppressive therapy. Patients with SAD had a better prognosis compared to those without SAD. When dividing all patients into three groups: isolated SAD (only small airway involvements), SAD with other lower airway involvements, and non‐SAD, patients in the SAD with other lower airway involvements group had the highest risk of infection, while patients in the non‐SAD group had the worst long‐term outcomes. Similar results were observed in anti‐MPO‐ANCA positive patients when performing subgroup analyses.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>SAD is a unique manifestation of AAV‐related lung involvement and exhibits distinct clinical features. It is vital to focus on SAD because of its association with prognosis and infection in AAV patients, especially in anti‐MPO‐ANCA positive patients. Moreover, SAD might represent a better response to immunosuppressors.</jats:p></jats:sec>

Palabras clave: Pulmonary and Respiratory Medicine.

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