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The last 30 years have seen extraordinary advances in the management of metastatic germ cell cancer of the testis. Prior to the advent of cisplatin-containing chemotherapy in the mid-1970s, chemotherapy was highly toxic, and gave poor results, with cure unusual in those with advanced disease. Following the introduction of cisplatin, and subsequently etoposide, progress has been rapid, not least in the development of ancillary drugs (e.g., 5- hydroxytryptamine [5-HT] antagonists and growth factors). Modern therapy is now usually curative, tolerable, and has few long-term side effects. Indeed, the current dearth of randomized trials for most subgroups of these patients is largely a testimony to the advances taking place during this period.

The last 30 years have seen extraordinary advances in the management of metastatic germ cell cancer of the testis. Prior to the advent of cisplatin-containing chemotherapy in the mid-1970s, chemotherapy was highly toxic, and gave poor results, with cure unusual in those with advanced disease. Following the introduction of cisplatin, and subsequently etoposide, progress has been rapid, not least in the development of ancillary drugs (e.g., 5- hydroxytryptamine [5-HT] antagonists and growth factors). Modern therapy is now usually curative, tolerable, and has few long-term side effects. Indeed, the current dearth of randomized trials for most subgroups of these patients is largely a testimony to the advances taking place during this period.

The last 30 years have seen extraordinary advances in the management of metastatic germ cell cancer of the testis. Prior to the advent of cisplatin-containing chemotherapy in the mid-1970s, chemotherapy was highly toxic, and gave poor results, with cure unusual in those with advanced disease. Following the introduction of cisplatin, and subsequently etoposide, progress has been rapid, not least in the development of ancillary drugs (e.g., 5- hydroxytryptamine [5-HT] antagonists and growth factors). Modern therapy is now usually curative, tolerable, and has few long-term side effects. Indeed, the current dearth of randomized trials for most subgroups of these patients is largely a testimony to the advances taking place during this period.

The last 30 years have seen extraordinary advances in the management of metastatic germ cell cancer of the testis. Prior to the advent of cisplatin-containing chemotherapy in the mid-1970s, chemotherapy was highly toxic, and gave poor results, with cure unusual in those with advanced disease. Following the introduction of cisplatin, and subsequently etoposide, progress has been rapid, not least in the development of ancillary drugs (e.g., 5- hydroxytryptamine [5-HT] antagonists and growth factors). Modern therapy is now usually curative, tolerable, and has few long-term side effects. Indeed, the current dearth of randomized trials for most subgroups of these patients is largely a testimony to the advances taking place during this period.

The last 30 years have seen extraordinary advances in the management of metastatic germ cell cancer of the testis. Prior to the advent of cisplatin-containing chemotherapy in the mid-1970s, chemotherapy was highly toxic, and gave poor results, with cure unusual in those with advanced disease. Following the introduction of cisplatin, and subsequently etoposide, progress has been rapid, not least in the development of ancillary drugs (e.g., 5- hydroxytryptamine [5-HT] antagonists and growth factors). Modern therapy is now usually curative, tolerable, and has few long-term side effects. Indeed, the current dearth of randomized trials for most subgroups of these patients is largely a testimony to the advances taking place during this period.

The last 30 years have seen extraordinary advances in the management of metastatic germ cell cancer of the testis. Prior to the advent of cisplatin-containing chemotherapy in the mid-1970s, chemotherapy was highly toxic, and gave poor results, with cure unusual in those with advanced disease. Following the introduction of cisplatin, and subsequently etoposide, progress has been rapid, not least in the development of ancillary drugs (e.g., 5- hydroxytryptamine [5-HT] antagonists and growth factors). Modern therapy is now usually curative, tolerable, and has few long-term side effects. Indeed, the current dearth of randomized trials for most subgroups of these patients is largely a testimony to the advances taking place during this period.

The last 30 years have seen extraordinary advances in the management of metastatic germ cell cancer of the testis. Prior to the advent of cisplatin-containing chemotherapy in the mid-1970s, chemotherapy was highly toxic, and gave poor results, with cure unusual in those with advanced disease. Following the introduction of cisplatin, and subsequently etoposide, progress has been rapid, not least in the development of ancillary drugs (e.g., 5- hydroxytryptamine [5-HT] antagonists and growth factors). Modern therapy is now usually curative, tolerable, and has few long-term side effects. Indeed, the current dearth of randomized trials for most subgroups of these patients is largely a testimony to the advances taking place during this period.

The last 30 years have seen extraordinary advances in the management of metastatic germ cell cancer of the testis. Prior to the advent of cisplatin-containing chemotherapy in the mid-1970s, chemotherapy was highly toxic, and gave poor results, with cure unusual in those with advanced disease. Following the introduction of cisplatin, and subsequently etoposide, progress has been rapid, not least in the development of ancillary drugs (e.g., 5- hydroxytryptamine [5-HT] antagonists and growth factors). Modern therapy is now usually curative, tolerable, and has few long-term side effects. Indeed, the current dearth of randomized trials for most subgroups of these patients is largely a testimony to the advances taking place during this period.