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<jats:p> The sister cities of El Paso, Texas and Ciudad Juárez, Chihuahua form one of the largest manufacturing complexes in the world, and provide a unique context in which to examine transnational patterns of environmental injustice. In this paper, we explore residential patterns of environmental injustice related to the location of industrial facilities (ie maquiladoras and facilities regulated by the Toxics Release Inventory) in the El Paso–Juárez metropolis, taking a comparative approach. Our results indicate a striking injustice in the raw level of industrial hazard confronted by residents on the Mexican side of the border compared with those on the US side—a direct result of location within the global economy. In terms of multivariate spatial regression results, patterns of exposure to residential hazards diverged between the two cities. In Mexico, generally marginal neighborhoods (based on low social class and higher proportions of migrants to the city) were located farther away from industry, whereas they were located closer in the US. We explain these findings on the basis of sociospatial differences in urbanization, social marginality, and industrial development between El Paso and Juárez, which reflect the two cities' juxtaposition vis-à-vis global political–economic dynamics. Future research is needed to test relationships between social marginality and industrial hazards in transnational and Southern contexts to determine if similar or divergent patterns exist. </jats:p>