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The American Journal of Cosmetic Surgery

Resumen/Descripción – provisto por la editorial en inglés

The American Journal of Cosmetic Surgery (AJCS) is the official publication of the American Academy of Cosmetic Surgery and is published quarterly in both print and online formats. The Journal features state-of-the-art cosmetic surgery procedures, topics and breakthroughs, all are written by distinguished experts in their respective fields. The Journal maintains a tradition of excellence in publishing original manuscripts relating to each area within cosmetic surgery, including Otolaryngology, Plastic and Reconstructive Surgery, Dermatology, Obstetrics/Gynecology, General Surgery, Ophthalmology and Oral and Maxillofacial Surgery. Peer-reviewed manuscripts reflect the highest quality and leading edge of knowledge.

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Disponibilidad

Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde mar. 1999 / hasta dic. 2023	SAGE Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0748-8068

ISSN electrónico

2374-7722

Editor responsable

SAGE Publishing (SAGE)

País de edición

Estados Unidos

Fecha de publicación

1984-

Cobertura temática

Medicina clínica

Tabla de contenidos

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doi: 10.5992/ajcs-d-12-00015.1

The Latest Advance in Hair Regeneration Therapy Using Proteins Secreted by Adipose-Derived Stem Cells

Hirotaro Fukuoka; Hirotaka Suga; Keigo Narita; Rei Watanabe; Satoru Shintani

<jats:sec><jats:title>Introduction:</jats:title><jats:p> Adipose-derived stem cells (ADSCs) that can be harvested from fat cells are one of the latest breakthroughs in the aesthetic field. In addition, basic studies have reported that ADSC conditioned medium (ADSC-CM) promotes skin and hair regeneration. We validate our novel approach, known as hair regenerative therapy, for hair growth treatment using ADSC-CM. </jats:p></jats:sec><jats:sec><jats:title>Materials and Methods:</jats:title><jats:p> ADSCs were cultured and expanded in hypoxic culture conditions, and ADSC-CM was collected. ADSC-CM includes various cytokines and growth factors that influence hair regrowth, to which we added buflomedyl, cysteine, coenzyme Q10, and vitamins. Protein solution from ADSC-CM was applied 4 to 6 times every 3 to 5 weeks by mesotherapy techniques such as nappage and papule injections. Satisfactory results of hair regenerative therapy in 12 women and 13 men were determined with a visual analog scale. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> All patients experienced increased hair growth from the treatments with ADSC-CM. Four treatment sessions performed within 3 to 4 months provided especially good results. Scores on the visual analog scale increased with treatment frequency. Statistical significance was determined by Friedman's 2-way analysis of variance (P < .01) and Wilcoxon's signed rank test (P < .01). </jats:p></jats:sec><jats:sec><jats:title>Discussion:</jats:title><jats:p> ADSCs secrete cytokines, such as keratinocyte growth factor, vascular endotheliatl growth factor, platelet-derived growth factor, hepatocyte growth factor. Those cytokines and growth factor are very important for hair growth. Our new therapy with ADSC-CM does not require specialized facilities, such as a cell-processing center, and can be a valuable treatment. </jats:p></jats:sec>

Pp. 273-282