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osteosarcoma; survival; prognosis; age groups; chemotherapy; metastasis; local recurrence; TEM1; VEGFR-1; EGFR; VEGFR-2; IGF-1R; PDGFRα; CD40; image guided surgery; near-infra red fluorescence; soft tissue sarcomas; angiosarcoma; paclitaxel; pazopanib; efficacy; toxicity; progression-free survival; sarcoma; radiotherapy; neoadjuvant therapy; hypofractionated radiotherapy; thermotherapy; hyperthermia; incisional biopsy; core needle biopsy; sensitivity; bone; soft tissue; LC3B; ATG16L1; p62; M6PR; PD-L1; CD8; notochord; tumor endoprosthesis; megaprosthesis; periprosthetic joint infection; revision surgery; bone sarcoma; extracellular acidosis; tumour microenvironment; tumour-associated stroma; acid-sensing ion channels; vacuolar-ATP-ase; carbonic anhydrase IX; acridine orange; soft tissue sarcoma; immune monitoring; immunophenotyping; cytokines; immune checkpoints; gene expression; Angiosarcoma; biomarkers; tumor microenvironment; immunotherapy; next-generation sequencing; whole transcriptome sequencing