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asthma; lactic acidosis; hyperchloremic acidosis; hypocapnia; hypercapnia; wheezing; bronchial biopsies; symptom persistence; clinical remission; eosinophil; adhesion; viability; proliferation; airway smooth muscle cell; pulmonary fibroblast; phenotype; acute severe asthma exacerbation; near fatal asthma; severe asthma; inflammation; interleukin-5 (IL-5); anti-IL-5; interleukin-4; airway remodeling; matrix metalloproteinases-9; tissue inhibitor of metalloproteinase-1; alveolar macrophages; lung function; bronchodilation; resistance; obstruction; reproducible; spirometry; obstructive sleep apnea; bronchial asthma; alternative overlap syndrome; exacerbation; reactive oxygen species; PBMC; mitochondrial function; innate immunity; immune regulation; NLRP3; IL-1β; allergic airway inflammation; microbiome; pathogenesis; immune responses; PreDicta; preschool; FeNO; asthma-specific quality of life; chronic rhinitis; disease-specific quality of life; health-related quality of Life (HRQLQ); children; longitudinal study