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Acta Physiologica
Resumen/Descripción – provisto por la editorial en inglés
Acta Physiologica is an important forum for the publication of high quality original research in physiology and related areas by authors from all over the world. Acta Physiologica is a leading journal in human/translational physiology while promoting all aspects of the science of physiology. The journal publishes full length original articles on important new observations as well as reviews and commentaries.Palabras clave – provistas por la editorial
acta physiologica scandinavica; cardiovascular system; gastroenterology; gastrointestinal system; mu
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde ene. 2006 / hasta dic. 2023 | Wiley Online Library |
Información
Tipo de recurso:
revistas
ISSN impreso
1748-1708
ISSN electrónico
1748-1716
Editor responsable
John Wiley & Sons, Inc. (WILEY)
País de edición
Reino Unido
Fecha de publicación
2006-
Cobertura temática
Tabla de contenidos
doi: 10.1111/apha.13561
Subcellular localization‐ and fibre type‐dependent utilization of muscle glycogen during heavy resistance exercise in elite power and Olympic weightlifters
Rune Hokken; Simon Laugesen; Per Aagaard; Charlotte Suetta; Ulrik Frandsen; Niels Ørtenblad; Joachim Nielsen
<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>Glycogen particles are found in different subcellular localizations, which are utilized heterogeneously in different fibre types during endurance exercise. Although resistance exercise typically involves only a moderate use of mixed muscle glycogen, the hypothesis of the present study was that high‐volume heavy‐load resistance exercise would mediate a pattern of substantial glycogen depletion in specific subcellular localizations and fibre types.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>10 male elite weightlifters performed resistance exercise consisting of four sets of five (4 × 5) repetitions at 75% of 1RM back squats, 4 × 5 at 75% of 1RM deadlifts and 4 × 12 at 65% of 1RM rear foot elevated split squats. Muscle biopsies (vastus lateralis) were obtained before and after the exercise session. The volumetric content of intermyofibrillar (between myofibrils), intramyofibrillar (within myofibrils) and subsarcolemmal glycogen was assessed by transmission electron microscopy.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>After exercise, biochemically determined muscle glycogen decreased by 38 (31:45)%. Location‐specific glycogen analyses revealed in type 1 fibres a large decrement in intermyofibrillar glycogen, but no or only minor changes in intramyofibrillar or subsarcolemmal glycogen. In type 2 fibres, large decrements in glycogen were observed in all subcellular localizations. Notably, a substantial fraction of the type 2 fibres demonstrated near‐depleted levels of intramyofibrillar glycogen after the exercise session.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Heavy resistance exercise mediates a substantial utilization of glycogen from all three subcellular localization in type 2 fibres, while mostly taxing intermyofibrillar glycogen stores in type 1 fibres. Thus, a better understanding of the impact of resistance training on myocellular metabolism and performance requires a focus on compartmentalized glycogen utilization.</jats:p></jats:sec>
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