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Institución detectada Período Navegá Descargá Solicitá
No detectada desde ene. 2005 / hasta dic. 2023 Wiley Online Library

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Tipo de recurso:

revistas

ISSN impreso

1613-6810

ISSN electrónico

1613-6829

País de edición

Estados Unidos

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Natural Carrier‐Free Binary Small Molecule Self‐Assembled Hydrogel Synergize Antibacterial Effects and Promote Wound Healing by Inhibiting Virulence Factors and Alleviating the Inflammatory Response

Zhijia Wang; Jihui Lu; Zhihua Yuan; Wenmin Pi; Xuemei Huang; Xiaoyu Lin; Yaozhi Zhang; Haimin Lei; Penglong WangORCID

<jats:title>Abstract</jats:title><jats:p>Methicillin‐resistant <jats:italic>Staphylococcus aureus</jats:italic> (MRSA)‐infected skin wounds have caused a variety of diseases and seriously endanger global public health. Therefore, multidimensional strategies are urgently to find antibacterial dressings to combat bacterial infections. Antibacterial hydrogels are considered potential wound dressing, while their clinical translation is limited due to the unpredictable risks and high costs of carrier excipients. it is found that the natural star antibacterial and anti‐inflammatory phytochemicals baicalin (BA) and sanguinarine (SAN) can directly self‐assemble through non‐covalent bonds such as electrostatic attraction, π–π stacking, and hydrogen bonding to form carrier‐free binary small molecule hydrogel. In addition, BA‐SAN gel exhibited a synergistic inhibitory effect on MRSA. And its plasticity and injectability allowed it to be applied as a wound dressing. Due to the matched physicochemical properties and synergistic therapeutic effects, BA‐SAN gel can inhibit bacterial virulence factors, alleviate wound inflammation, promote wound healing, and has good biocompatibility. The current study not only provided an antibacterial hydrogel with clinical value but also opened up new prospects that carrier‐free hydrogels can be designed and originated from clinically used small‐molecule phytochemicals.</jats:p>

Palabras clave: Biomaterials; Biotechnology; General Materials Science; General Chemistry.

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A Paradigm Shift from 2D to 3D: Surface Supramolecular Assemblies and Their Electronic Properties Explored by Scanning Tunneling Microscopy and Spectroscopy

Rongbin Xie; Yi HuORCID; Shern‐Long LeeORCID

<jats:title>Abstract</jats:title><jats:p>Exploring supramolecular architectures at surfaces plays an increasingly important role in contemporary science, especially for molecular electronics. A paradigm of research interest in this context is shifting from 2D to 3D that is expanding from monolayer, bilayers, to multilayers. Taking advantage of its high‐resolution insight into monolayers and a few layers, scanning tunneling microscopy/spectroscopy (STM/STS) turns out a powerful tool for analyzing such thin films on a solid surface. This review summarizes the representative efforts of STM/STS studies of layered supramolecular assemblies and their unique electronic properties, especially at the liquid–solid interface. The superiority of the 3D molecular networks at surfaces is elucidated and an outlook on the challenges that still lie ahead is provided. This review not only highlights the profound progress in 3D supramolecular assemblies but also provides researchers with unusual concepts to design surface supramolecular structures with increasing complexity and desired functionality.</jats:p>

Palabras clave: Biomaterials; Biotechnology; General Materials Science; General Chemistry.

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