Catálogo de publicaciones - tesis
Título de Acceso Abierto
Mecanismos que analizan a nivel hepático el destino de los ácidos grasos del plasma y su relación con la resistencia insulínica en dislipemia experimental: Estrategias de prevención y/o mejoramiento por dietas
Gustavo Juan Hein Yolanda Rosa Bolzón de Lombardo Alicia Jawerbaum Laura Schreier Carlos Alberto Marra Adriana Graciela Chicco
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Resumen/Descripción – provisto por el repositorio digital
The results show that chronic administration of a sucrose rich diet (SRD) induced in liver: increased protein mass of the nuclear receptor LXR alpha and decreased mass of PPAR alpha. This related to the activation of lipogenic enzymes and decreased activity of fatty acid oxidation enzymes, indicating a preferential destiny of them towards reesterification pathway and hepatic triglyceride synthesis. Furthermore, the dyslipidemic animals exhibited impaired insulin action in liver tissue associated with lower IRS 1 and alpha subunit p85 mass protein. This would explain the moderate hyperglycemia present in these animals. The cod liver oil (CLO) produced: increased activity of fatty acid oxidation enzymes and lipogenic enzyme normalization with increased PPAR alpha protein mass and decreased LXR alpha mass. This indicates: lower “de novo” fatty acids synthesis and increased oxidative pathways with reduced availability of plasma fatty acids to the liver, contribute to the reversal of hepatic steatosis and dyslipidemia. Furthermore, reduced expression of IRS 1 and alpha subunit p85 protein mass observed in animals with SRD failed to revert completely with CLO. The reversal of the global peripheral insulin resistance and improving insulin sensitivity in the liver, with normalization of insulin secretion in vitro in perifused isolated islets, would lead to restoration of glycemia within normal levels with CLO.Palabras clave – provistas por el repositorio digital
Sucrose rich diet; Liver; Cod liver oil; Insulin resistance; Dislypidemia; Nuclear receptors; Hígado; Dieta rica en sacarosa; Aceite de hígado de bacalao; Resistencia insulínica; Dislipidemia; Receptores nucleares
Disponibilidad
| Institución detectada | Año de publicación | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No requiere | 2010 | Biblioteca Virtual de la Universidad Nacional del Litoral (SNRD) |
|
Información
Tipo de recurso:
tesis
Idiomas de la publicación
- español castellano
País de edición
Argentina
Fecha de publicación
2010-03-04
