Catálogo de publicaciones - revistas

<jats:p>Blood tests can detect the disease process early, avoiding complications and aiding treatment</jats:p>

<jats:p>Inspectors faulted analyses of clinical trial samples by Hoau-Yan Wang for drug developer Cassava Sciences</jats:p>

<jats:p>“Smart cables” will detect earthquakes, tsunamis, and global warming</jats:p>

<jats:p>Jeanne Marrazzo, an HIV prevention researcher, sees need for more “holistic” approach to community health problems</jats:p>

<jats:p>The mystery of “infantile amnesia” suggests memory works differently in the developing brain</jats:p>

<jats:p>Reducing defects boosts room-temperature performance of a thermoelectric device</jats:p>

<jats:p>A provocative proposition paves the way for a long-overdue conversation about consciousness</jats:p>

<jats:p>Printable mesoscopic perovskite solar cells (p-MPSCs) do not require the added hole-transport layer needed in traditional p-n junctions but have also exhibited lower power conversion efficiencies of about 19%. We performed device simulation and carrier dynamics analysis to design a p-MPSC with mesoporous layers of semiconducting titanium dioxide, insulating zirconium dioxide, and conducting carbon infiltrated with perovskite that enabled three-dimensional injection of photoexcited electrons into titanium dioxide for collection at a transparent conductor layer. Holes underwent long-distance diffusion toward the carbon back electrode, and this carrier separation reduced recombination at the back contact. Nonradiative recombination at the bulk titanium dioxide/perovskite interface was reduced by ammonium phosphate modification. The resulting p-MPSCs achieved a power conversion efficiency of 22.2% and maintained 97% of their initial efficiency after 750 hours of maximum power point tracking at 55 ± 5°C.</jats:p>

<jats:p>DNA replication is initiated at multiple loci to ensure timely duplication of eukaryotic genomes. Sister replication forks progress bidirectionally, and replication terminates when two convergent forks encounter one another. To investigate the coordination of replication forks, we developed a replication-associated in situ HiC method to capture chromatin interactions involving nascent DNA. We identify more than 2000 fountain-like structures of chromatin contacts in human and mouse genomes, indicative of coupling of DNA replication forks. Replication fork interaction not only occurs between sister forks but also involves forks from two distinct origins to predetermine replication termination. Termination-associated chromatin fountains are sensitive to replication stress and lead to coupled forks–associated genomic deletions in cancers. These findings reveal the spatial organization of DNA replication forks within the chromatin context.</jats:p>