Catálogo de publicaciones - revistas

<jats:title>Tertiary lymphoid structures in cancer</jats:title> <jats:p>Tertiary lymphoid structures (TLSs) are lymphoid formations that are found in nonlymphoid tissues. TLS can develop in inflamed tissues and are associated with chronic inflammatory disorders, autoimmunity, and cancer. In the setting of tumors, TLSs facilitate the influx of immune cells into the tumor site and have therefore attracted interest as a means of improving anticancer immunity and favorable treatment response in patients. Schumacher and Thommen review the biology of TLSs and outline recent advances in TLS research. They discuss how TLSs are detected and defined, the mechanism(s) of formation in cancer, and the potential of targeting TLSs for therapeutic benefit. —PNK</jats:p>

<jats:title>Spatial and temporal organoid control</jats:title> <jats:p> Stem cell–derived organoids form through self-organization and serve as models for organ development, function, and disease, with potential applications in drug development and personalized medicine. However, in the absence of external guidance, developmental processes are stochastic, resulting in variable end products that differ significantly from the native organ. Gjorevski <jats:italic>et al</jats:italic> . developed approaches for specifying the initial organoid geometry to build intestinal organoids of defined shape, size, and cell distributions, forming structures that are predictable, more similar to normal organs, and reproducible (see the Perspective by Huycke and Gartner). These methods identify symmetry-breaking mechanisms in intestinal morphogenesis and have potential for standardizing organoid-based therapies and facilitating the refinement of mechanistic studies. —BAP </jats:p>

<jats:p> The first editorial of the year is generally an invitation to look forward. Often, we announce new initiatives at the <jats:italic>Science</jats:italic> family of journals or changes to our policies. This year, I want to look forward in a different way—by looking back. <jats:italic>Science</jats:italic> has a history that includes shame in addition to accomplishment. In 2021, we began to explore and acknowledge some of that regretful past, and we’ll continue this examination in 2022. </jats:p>

<jats:p>Many countries break infection records; how much severe disease they will see is unclear</jats:p>

<jats:p>Jury finds Harvard University chemist guilty of lying about ties to China</jats:p>

<jats:p>Farms added 100 million hectares globally over 2 decades, threatening biodiversity and accelerating climate change</jats:p>

<jats:p>Five academics have resettled in Kigali with help from the U.S. National Academies</jats:p>

<jats:p>DNA in air reveals the plants below—and requires no tromping through bushes</jats:p>

<jats:p>Data could improve climate models and provide warnings for infrastructure vulnerable to thawing soil</jats:p>