Catálogo de publicaciones - revistas

<jats:p>Warmer and brighter cities trick trees into thinking that spring arrives earlier</jats:p>

<jats:p>Mutations trace the evolution of an ancient tumor lineage</jats:p>

<jats:p>The inner nuclear membrane has an expanded role in lipid metabolism</jats:p>

<jats:p>The distinct properties of brown adipose tissue may be harnessed to mitigate obesity</jats:p>

<jats:p>Inflammatory processes that recruit leukocytes to injured or infected tissues are crucial for tissue repair and the elimination of pathogens. However, excessive or chronic inflammation promotes tissue damage and disease, as in arthritis, atherosclerosis, inflammatory bowel disease, and COVID-19. Intracellular constituents released from dying cells are among the stimuli that trigger proinflammatory gene expression programs in innate immune cells. We explore how programmed cell death mechanisms—apoptosis, necroptosis, and pyroptosis—may contribute to inflammatory disease. We discuss inhibition of cell death as a potential therapeutic strategy, focusing on the targets RIPK1 (receptor interacting serine/threonine kinase 1), NLRP3 (NLR family pyrin domain containing 3), and GSDMD (gasdermin D) as important mediators of lytic cell death. We also consider the potential benefits of limiting membrane rupture rather than cell death by targeting NINJ1.</jats:p>