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<jats:title>DNA repair amplifies transcriptional noise</jats:title> <jats:p> The potential role of noise, or stochastic variations in rates of gene expression, remains to be elucidated. Desai <jats:italic>et al</jats:italic> . used screens to identify a compound, 5′-iodo-2–-deoxyuridine (IdU), that increased gene expression noise in mouse embryonic stem cells in culture without changing the overall rate of transcription of most genes. They propose a model by which the thymidine analog IdU promotes binding of the base excision repair protein AP endonuclease to DNA, thereby inducing helical distortion of DNA and modulating transcriptional bursting. Such modulation of noise enhanced reprogramming of the embryonic stem cells. Thus, variation in gene expression noise could influence developmental or disease processes. —LBR </jats:p>

<jats:p>In 1953, the proposed structure of DNA magnificently linked biological function and structure. By contrast, 4 years later, the first elucidation of the structure of a protein—myoglobin, by Kendrew and colleagues—revealed an inelegant shape, described disdainfully as a “visceral knot.” Additional complexity, as well as some general principles, was revealed as more protein structures were solved over the next decade. In 1971, scientists at Brookhaven National Laboratory launched the Protein Data Bank (PDB) as a repository to collect and make available the atomic coordinates of structures (seven at the time) to interested parties. The PDB now includes more than 180,000 structures, and this resource has fueled an incalculable number of advances, including the recent development of powerful structure prediction tools.</jats:p>

<jats:p>With early vaccination and outstanding data, country is the world’s real-life COVID-19 lab</jats:p>

<jats:p>Excavation finds evidence of both perpetrators and victims of WWII atrocity</jats:p>

<jats:p>Climate advocates want the world’s largest carbon producer to level off emissions soon and aim for “neutrality” by 2050</jats:p>

<jats:p>Monoclonal antibodies protected people from infection in a small “challenge” trial</jats:p>

<jats:p>New variants have changed the face of the pandemic. What will the virus do next?</jats:p>

<jats:p>How transmission bottlenecks influence virus evolution</jats:p>