Catálogo de publicaciones - revistas

<jats:title>A deadly cascade</jats:title> <jats:p> A catastrophic landslide in Uttarakhand state in India on February 2021 damaged two hydropower plants, and more than 200 people were killed or are missing. Shugar <jats:italic>et al.</jats:italic> describe the cascade of events that led to this disaster. A massive rock and ice avalanche roared down a Himalayan valley, turning into a deadly debris flow upstream from the first of the two hydropower plants. The sequence of events highlights the increasing risk in the Himalayas caused by increased warming and development. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , abh4455, this issue p. <jats:related-article issue="6552" page="300" related-article-type="in-this-issue" vol="373">300</jats:related-article> </jats:p>

<jats:title>Chromatin landscape dictates remodeling</jats:title> <jats:p> Large, multicomponent molecular machines known as mammalian SWI/SNF (mSWI/SNF) chromatin-remodeling complexes play critical roles in governing the architecture of our genomes. These entities bind to chromatin (DNA assembled on proteins) inside the nucleus and dictate which regions of DNA, and thus which genes in our genome, are made accessible. It is critical that this process happens at the right times and for the right genes in cells, because disruptions cause diseases such as cancers and neurodevelopmental disorders. Mashtalir <jats:italic>et al.</jats:italic> uncovered molecular cues that direct complex activities on chromatin, informing specific interactions that may be amenable to therapeutic targeting. This combinatorial approach, which considers many factors involved in determining mSWI/SNF activity, provides a valuable resource for understanding the binding and activity of chromatin-remodeling complexes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , abf8705, this issue p. <jats:related-article issue="6552" page="306" related-article-type="in-this-issue" vol="373">306</jats:related-article> </jats:p>