Catálogo de publicaciones - revistas

<jats:title>Down with leukemia</jats:title> <jats:p> Down syndrome is a congenital disorder caused by the trisomy of chromosome 21, and it is associated with a greatly increased risk of leukemia with origins in fetal development. Infants with Down syndrome are often born with a preleukemic condition, which later resolves in most cases. By using gene-edited human cells implanted into mouse models, Wagenblast <jats:italic>et al.</jats:italic> recapitulated the development of preleukemia and leukemia in the context of Down syndrome (see the Perspective by Roberts and Vyas). A specific mutation triggered a preleukemic condition in the context of trisomy 21 as expected, but progression to full-blown leukemia required a different genetic path and was not dependent on trisomy 21. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , abf6202, this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abf6202">eabf6202</jats:related-article> ; see also abj3957, p. <jats:related-article issue="6551" page="155" related-article-type="in-this-issue" vol="373">155</jats:related-article> </jats:p>

<jats:title>Correlates of infectiousness</jats:title> <jats:p> The role that individuals with asymptomatic or mildly symptomatic severe acute respiratory syndrome coronavirus 2 have in transmission of the virus is not well understood. Jones <jats:italic>et al.</jats:italic> investigated viral load in patients, comparing those showing few, if any, symptoms with hospitalized cases. Approximately 400,000 individuals, mostly from Berlin, were tested from February 2020 to March 2021 and about 6% tested positive. Of the 25,381 positive subjects, about 8% showed very high viral loads. People became infectious within 2 days of infection, and in hospitalized individuals, about 4 days elapsed from the start of virus shedding to the time of peak viral load, which occurred 1 to 3 days before the onset of symptoms. Overall, viral load was highly variable, but was about 10-fold higher in persons infected with the B.1.1.7 variant. Children had slightly lower viral loads than adults, although this difference may not be clinically significant. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , abi5273, this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abi5273">eabi5273</jats:related-article> </jats:p>

<jats:title>Captivating cavities</jats:title> <jats:p> Laser technology is a familiar example of how confining light between two mirrors can tune its properties. Quantum mechanics also dictates that even without extraneous light, matter confined in a cavity resonant with its electronic or vibrational transitions can couple with vacuum electromagnetic field fluctuations. Garcia-Vidal <jats:italic>et al.</jats:italic> review the remarkable and still somewhat mysterious implications of this “strong-coupling” regime, with manifestations ranging from enhanced charge transport to site-selective chemical reactivity across a range of molecular and solid-state materials. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , abd0336, this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abd0336">eabd0336</jats:related-article> </jats:p>

<jats:p>Sitting at the interface of human societies and the natural environment are sentinels tracking environmental change. Across the globe, field stations and marine laboratories (FSMLs) amass crucial information about climate, biodiversity, environmental health, and emerging diseases, anchoring multidecadal data sets needed to solve environmental challenges of the Anthropocene. These observatories are now in danger of being shut down—part of the collateral damage of the COVID-19 pandemic.</jats:p>

<jats:p>A roundup of weekly science policy and related news</jats:p>

<jats:p>Elusive "correlates of protection" could lead to approvals of boosters or new vaccines without big clinical trials</jats:p>

<jats:p>New studies highlight underappreciated role of avian olfaction</jats:p>

<jats:p>Despite suggestions of differential effects, most clinical trials don't report results by sex</jats:p>

<jats:p>Birds with crusty eyes and neurological damage found in nine states and Washington, D.C.</jats:p>