Catálogo de publicaciones - revistas

<jats:title>Always stressed</jats:title> <jats:p> The integrated stress response (ISR) plays a role in proteostasis and is important in the brain for learning and memory. Typically, the pathway is thought to be activated transiently to fulfill these roles but may become persistent in disease states. Helseth <jats:italic>et al.</jats:italic> developed a reporter to study ISR activation brainwide and found a class of cells that engage ISR for steady-state cell function (see the Perspective by Ingebretson and Lemos). In mice, cholinergic interneurons required the ISR to maintain properties of tonic firing and response to dopamine. Inhibiting the ISR in these cells changed dopamine neuromodulation and enhanced performance in learned tasks. Thus, ISR engagement can play a steady-state role that is independent of cell stress and important in learning. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abe1931">eabe1931</jats:related-article> ; see also p. <jats:related-article issue="6540" page="345" related-article-type="in-this-issue" vol="372">345</jats:related-article> </jats:p>

<jats:title>Single-cell analysis of CNS interactions</jats:title> <jats:p> Despite their importance in the physiology and pathology of the central nervous system (CNS), few methods are available for the unbiased, systematic investigation of cell-to-cell interactions at single-cell resolution. Clark <jats:italic>et al.</jats:italic> developed RABID-seq, a method that combines barcoded viral tracing with single-cell RNA sequencing (see the Perspective by Silvin and Ginhoux). RABID-seq identified the axon guidance molecules Sema4D-PlexinB2 and EphrinB3-EphB3 as mediators of microglia-astrocyte interactions that promote CNS pathology in experimental autoimmune encephalomyelitis and, potentially, multiple sclerosis. These studies also identified candidate therapeutic molecules for the modulation of microglia-astrocyte interactions in multiple sclerosis. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abf1230">eabf1230</jats:related-article> ; see also p. <jats:related-article issue="6540" page="342" related-article-type="in-this-issue" vol="372">342</jats:related-article> </jats:p>

<jats:title>Regeneration without scarring</jats:title> <jats:p> Wounds in adult mammals typically heal by forming fibrotic scars. Mascharak <jats:italic>et al.</jats:italic> found that a specific population of skin fibroblasts ( <jats:italic>Engrailed-1</jats:italic> lineage–negative fibroblasts) activate expression of <jats:italic>Engrailed-1</jats:italic> and turn on profibrotic cellular programs in response to local tissue mechanics in wounds (see the Perspective by Konieczny and Naik). When mechanical signaling was inhibited in these cells (using either genetic deletion or small-molecule inhibition), skin wounds in mice no longer formed scars but instead healed by regeneration, restoring skin with normal hair follicles and glands, extracellular matrix, and mechanical strength. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aba2374">eaba2374</jats:related-article> ; see also p. <jats:related-article issue="6540" page="346" related-article-type="in-this-issue" vol="372">346</jats:related-article> </jats:p>

<jats:p>By the early 1920s, an unlikely pair—a powerful national newspaper publisher and a California-based zoologist—decided that they'd had enough. Enough of half-baked reporting on research results, enough of stories that left readers confused about even the basic principles of science. They wanted something better. They wanted reporting that encouraged a “scientific habit of mind,” a citizenry aware of the role of research in everyday life.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Project could help avert catastrophic flooding, but threatens research plots.</jats:p>

<jats:p>Scientists applaud end of intramural research ban and Trump-era review board.</jats:p>

<jats:p>Some scientists see deal and reorganization as "corporatization" of historic institution.</jats:p>

<jats:p>Researchers blame a squeeze in basic research funding and scarce venture capital for biotech startups.</jats:p>

<jats:p>Paleontologists raise questions of access to exquisite specimen.</jats:p>