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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Skin cells undergo asynthetic fission to expand body surfaces in zebrafish
Keat Ying Chan; Ching-Cher Sanders Yan; Hsiao-Yuh Roan; Shao-Chun Hsu; Tzu-Lun Tseng; Chung-Der Hsiao; Chao-Ping Hsu
; Chen-Hui Chen
Palabras clave: Multidisciplinary.
Pp. 119-125
Generation of 3D lacrimal gland organoids from human pluripotent stem cells
Ryuhei Hayashi; Toru Okubo; Yuji Kudo; Yuki Ishikawa; Tsutomu Imaizumi; Kenji Suzuki; Shun Shibata; Tomohiko Katayama; Sung-Joon Park; Robert D. Young; Andrew J. Quantock; Kohji Nishida
Palabras clave: Multidisciplinary.
Pp. 126-131
Chemotaxis shapes the microscale organization of the ocean’s microbiome
Jean-Baptiste Raina; Bennett S. Lambert; Donovan H. Parks; Christian Rinke; Nachshon Siboni; Anna Bramucci; Martin Ostrowski; Brandon Signal; Adrian Lutz; Himasha Mendis; Francesco Rubino; Vicente I. Fernandez; Roman Stocker; Philip Hugenholtz; Gene W. Tyson; Justin R. Seymour
Palabras clave: Multidisciplinary.
Pp. 132-138
Programme of self-reactive innate-like T cell-mediated cancer immunity
Chun Chou; Xian Zhang; Chirag Krishna; Briana G. Nixon; Saida Dadi; Kristelle J. Capistrano; Emily R. Kansler; Miranda Steele; Jian Han; Amy Shyu; Jing Zhang; Efstathios G. Stamatiades; Ming Liu; Shun Li; Mytrang H. Do; Chaucie Edwards; Davina S. Kang; Chin-Tung Chen; Iris H. Wei; Emmanouil P. Pappou; Martin R. Weiser; J. Garcia-Aguilar; J. Joshua Smith; Christina S. Leslie; Ming O. Li
Palabras clave: Multidisciplinary.
Pp. 139-145
Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19
Lok-Yin Roy Wong; Jian Zheng; Kevin Wilhelmsen; Kun Li; Miguel E. Ortiz; Nicholas J. Schnicker; Andrew Thurman; Alejandro A. Pezzulo; Peter J. Szachowicz; Pengfei Li; Ruangang Pan; Klaus Klumpp; Fred Aswad; Justin Rebo; Shuh Narumiya; Makoto Murakami; Sonia Zuniga; Isabel Sola; Luis Enjuanes; David K. Meyerholz; Kristen Fortney; Paul B. McCray; Stanley Perlman
Palabras clave: Multidisciplinary.
Pp. 146-151
β-Hydroxybutyrate suppresses colorectal cancer
Oxana Dmitrieva-Posocco; Andrea C. Wong; Patrick Lundgren; Aleksandra M. Golos; Hélène C. Descamps; Lenka Dohnalová; Zvi Cramer; Yuhua Tian; Brian Yueh; Onur Eskiocak; Gabor Egervari; Yemin Lan; Jinping Liu; Jiaxin Fan; Jihee Kim; Bhoomi Madhu; Kai Markus Schneider; Svetlana Khoziainova; Natalia Andreeva; Qiaohong Wang; Ning Li; Emma E. Furth; Will Bailis; Judith R. Kelsen; Kathryn E. Hamilton; Klaus H. Kaestner; Shelley L. Berger; Jonathan A. Epstein; Rajan Jain; Mingyao Li; Semir Beyaz; Christopher J. Lengner; Bryson W. Katona; Sergei I. Grivennikov; Christoph A. Thaiss; Maayan Levy
Palabras clave: Multidisciplinary.
Pp. 160-165
Structure of human chromatin-remodelling PBAF complex bound to a nucleosome
Junjie Yuan; Kangjing Chen; Wenbo Zhang; Zhucheng Chen
Palabras clave: Multidisciplinary.
Pp. 166-171
Opening of glutamate receptor channel to subconductance levels
Maria V. Yelshanskaya; Dhilon S. Patel; Christopher M. Kottke; Maria G. Kurnikova; Alexander I. Sobolevsky
<jats:title>Abstract</jats:title><jats:p>Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that open their pores in response to binding of the agonist glutamate<jats:sup>1–3</jats:sup>. An ionic current through a single iGluR channel shows up to four discrete conductance levels (O1–O4)<jats:sup>4–6</jats:sup>. Higher conductance levels have been associated with an increased number of agonist molecules bound to four individual ligand-binding domains (LBDs)<jats:sup>6–10</jats:sup>. Here we determine structures of a synaptic complex of AMPA-subtype iGluR and the auxiliary subunit γ2 in non-desensitizing conditions with various occupancy of the LBDs by glutamate. We show that glutamate binds to LBDs of subunits B and D only after it is already bound to at least the same number of LBDs that belong to subunits A and C. Our structures combined with single-channel recordings, molecular dynamics simulations and machine-learning analysis suggest that channel opening requires agonist binding to at least two LBDs. Conversely, agonist binding to all four LBDs does not guarantee maximal channel conductance and favours subconductance states O1 and O2, with O3 and O4 being rare and not captured structurally. The lack of subunit independence and low efficiency coupling of glutamate binding to channel opening underlie the gating of synaptic complexes to submaximal conductance levels, which provide a potential for upregulation of synaptic activity.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 172-178
Scientific collaborations are precarious territory for women
Sara Reardon
Palabras clave: Multidisciplinary.
Pp. 179-181
Unlocking the potential of health data to help research and treatments
Jyoti Madhusoodanan
Palabras clave: Multidisciplinary.
Pp. 182-183