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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Compartmentalized metabolism supports midgestation mammalian development
Ashley Solmonson; Brandon Faubert
; Wen Gu; Aparna Rao; Mitzy A. Cowdin; Ivan Menendez-Montes; Sherwin Kelekar; Thomas J. Rogers; Chunxiao Pan; Gerardo Guevara; Amy Tarangelo; Lauren G. Zacharias; Misty S. Martin-Sandoval; Duyen Do; Panayotis Pachnis; Dennis Dumesnil; Thomas P. Mathews; Alpaslan Tasdogan; An Pham; Ling Cai; Zhiyu Zhao; Min Ni; Ondine Cleaver; Hesham A. Sadek; Sean J. Morrison; Ralph J. DeBerardinis
<jats:title>Abstract</jats:title><jats:p>Mammalian embryogenesis requires rapid growth and proper metabolic regulation<jats:sup>1</jats:sup>. Midgestation features increasing oxygen and nutrient availability concomitant with fetal organ development<jats:sup>2,3</jats:sup>. Understanding how metabolism supports development requires approaches to observe metabolism directly in model organisms in utero. Here we used isotope tracing and metabolomics to identify evolving metabolic programmes in the placenta and embryo during midgestation in mice. These tissues differ metabolically throughout midgestation, but we pinpointed gestational days (GD) 10.5–11.5 as a transition period for both placenta and embryo. Isotope tracing revealed differences in carbohydrate metabolism between the tissues and rapid glucose-dependent purine synthesis, especially in the embryo. Glucose’s contribution to the tricarboxylic acid (TCA) cycle rises throughout midgestation in the embryo but not in the placenta. By GD12.5, compartmentalized metabolic programmes are apparent within the embryo, including different nutrient contributions to the TCA cycle in different organs. To contextualize developmental anomalies associated with Mendelian metabolic defects, we analysed mice deficient in LIPT1, the enzyme that activates 2-ketoacid dehydrogenases related to the TCA cycle<jats:sup>4,5</jats:sup>. LIPT1 deficiency suppresses TCA cycle metabolism during the GD10.5–GD11.5 transition, perturbs brain, heart and erythrocyte development and leads to embryonic demise by GD11.5. These data document individualized metabolic programmes in developing organs in utero.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 349-353
Anatomic position determines oncogenic specificity in melanoma
Joshua M. Weiss; Miranda V. Hunter; Nelly M. Cruz; Arianna Baggiolini; Mohita Tagore; Yilun Ma; Sandra Misale; Michelangelo Marasco; Theresa Simon-Vermot; Nathaniel R. Campbell; Felicity Newell; James S. Wilmott; Peter A. Johansson; John F. Thompson; Georgina V. Long; John V. Pearson; Graham J. Mann; Richard A. Scolyer; Nicola Waddell; Emily D. Montal; Ting-Hsiang Huang; Philip Jonsson; Mark T. A. Donoghue; Christopher C. Harris; Barry S. Taylor; Tianhao Xu; Ronan Chaligné; Pavel V. Shliaha; Ronald Hendrickson; Achim A. Jungbluth; Cecilia Lezcano; Richard Koche; Lorenz Studer; Charlotte E. Ariyan; David B. Solit; Jedd D. Wolchok; Taha Merghoub; Neal Rosen; Nicholas K. Hayward; Richard M. White
Palabras clave: Multidisciplinary.
Pp. 354-361
N6-methyladenosine in poly(A) tails stabilize VSG transcripts
Idálio J. Viegas; Juan Pereira de Macedo; Lúcia Serra; Mariana De Niz; Adriana Temporão; Sara Silva Pereira; Aashiq H. Mirza; Ed Bergstrom; João A. Rodrigues; Francisco Aresta-Branco; Samie R. Jaffrey; Luisa M. Figueiredo
Palabras clave: Multidisciplinary.
Pp. 362-370
Structural basis of lipopolysaccharide maturation by the O-antigen ligase
Khuram U. Ashraf; Rie Nygaard; Owen N. Vickery; Satchal K. Erramilli; Carmen M. Herrera; Thomas H. McConville; Vasileios I. Petrou; Sabrina I. Giacometti; Meagan Belcher Dufrisne; Kamil Nosol; Allen P. Zinkle; Chris L. B. Graham; Michael Loukeris; Brian Kloss; Karolina Skorupinska-Tudek; Ewa Swiezewska; David I. Roper; Oliver B. Clarke; Anne-Catrin Uhlemann; Anthony A. Kossiakoff; M. Stephen Trent; Phillip J. Stansfeld; Filippo Mancia
Palabras clave: Multidisciplinary.
Pp. 371-376
Structure deformation and curvature sensing of PIEZO1 in lipid membranes
Xuzhong Yang; Chao Lin; Xudong Chen; Shouqin Li; Xueming Li; Bailong Xiao
Palabras clave: Multidisciplinary.
Pp. 377-383
Capturing a rhodopsin receptor signalling cascade across a native membrane
Siyun Chen; Tamar Getter; David Salom; Di Wu; Daniel Quetschlich; Dror S. Chorev; Krzysztof Palczewski; Carol V. Robinson
<jats:title>Abstract</jats:title><jats:p>G protein-coupled receptors (GPCRs) are cell-surface receptors that respond to various stimuli to induce signalling pathways across cell membranes. Recent progress has yielded atomic structures of key intermediates<jats:sup>1,2</jats:sup> and roles for lipids in signalling<jats:sup>3,4</jats:sup>. However, capturing signalling events of a wild-type receptor in real time, across a native membrane to its downstream effectors, has remained elusive. Here we probe the archetypal class A GPCR, rhodopsin, directly from fragments of native disc membranes using mass spectrometry. We monitor real-time photoconversion of dark-adapted rhodopsin to opsin, delineating retinal isomerization and hydrolysis steps, and further showing that the reaction is significantly slower in its native membrane than in detergent micelles. Considering the lipids ejected with rhodopsin, we demonstrate that opsin can be regenerated in membranes through photoisomerized retinal–lipid conjugates, and we provide evidence for increased association of rhodopsin with unsaturated long-chain phosphatidylcholine during signalling. Capturing the secondary steps of the signalling cascade, we monitor light activation of transducin (G<jats:sub>t</jats:sub>) through loss of GDP to generate an intermediate apo-trimeric G protein, and observe Gα<jats:sub>t</jats:sub>•GTP subunits interacting with PDE6 to hydrolyse cyclic GMP. We also show how rhodopsin-targeting compounds either stimulate or dampen signalling through rhodopsin–opsin and transducin signalling pathways. Our results not only reveal the effect of native lipids on rhodopsin signalling and regeneration but also enable us to propose a paradigm for GPCR drug discovery in native membrane environments.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 384-390
The marine biologist whose photography pastime became a profession
Alexander Semenov
Palabras clave: Multidisciplinary.
Pp. 391-392
A grass-roots science movement to rebuild Lebanon
Benjamin Plackett
Palabras clave: Multidisciplinary.
Pp. 394-394
Goodnight, Moon
Wendy Nikel
Palabras clave: Multidisciplinary.
Pp. No disponible
Coronapod: infected immune cells hint at cause of severe COVID
Noah Baker; Smriti Mallapaty
Palabras clave: Multidisciplinary.
Pp. No disponible