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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
FSH blockade improves cognition in mice with Alzheimer’s disease
Jing Xiong; Seong Su Kang; Zhihao Wang; Xia Liu; Tan-Chun Kuo
; Funda Korkmaz; Ashley Padilla; Sari Miyashita; Pokman Chan; Zhaohui Zhang; Pavel Katsel; Jocoll Burgess; Anisa Gumerova; Kseniia Ievleva; Damini Sant; Shan-Ping Yu; Valeriia Muradova; Tal Frolinger; Daria Lizneva; Jameel Iqbal; Ki A. Goosens; Sakshi Gera; Clifford J. Rosen; Vahram Haroutunian; Vitaly Ryu; Tony Yuen; Mone Zaidi; Keqiang Ye
Palabras clave: Multidisciplinary.
Pp. 470-476
A non-canonical tricarboxylic acid cycle underlies cellular identity
Paige K. Arnold; Benjamin T. Jackson; Katrina I. Paras; Julia S. Brunner; Madeleine L. Hart; Oliver J. Newsom; Sydney P. Alibeckoff; Jennifer Endress; Esther Drill; Lucas B. Sullivan; Lydia W. S. Finley
Palabras clave: Multidisciplinary.
Pp. 477-481
Methane formation driven by reactive oxygen species across all living organisms
Leonard Ernst; Benedikt Steinfeld; Uladzimir Barayeu; Thomas Klintzsch; Markus Kurth; Dirk Grimm; Tobias P. Dick; Johannes G. Rebelein; Ilka B. Bischofs; Frank Keppler
Palabras clave: Multidisciplinary.
Pp. 482-487
T cell responses to SARS-CoV-2 spike cross-recognize Omicron
Roanne Keeton; Marius B. Tincho; Amkele Ngomti; Richard Baguma; Ntombi Benede; Akiko Suzuki; Khadija Khan; Sandile Cele; Mallory Bernstein; Farina Karim; Sharon V. Madzorera; Thandeka Moyo-Gwete; Mathilda Mennen; Sango Skelem; Marguerite Adriaanse; Daniel Mutithu; Olukayode Aremu; Cari Stek; Elsa du Bruyn; Mieke A. Van Der Mescht; Zelda de Beer; Talita R. de Villiers; Annie Bodenstein; Gretha van den Berg; Adriano Mendes; Amy Strydom; Marietjie Venter; Jennifer Giandhari; Yeshnee Naidoo; Sureshnee Pillay; Houriiyah Tegally; Alba Grifoni; Daniela Weiskopf; Alessandro Sette; Robert J. Wilkinson; Tulio de Oliveira; Linda-Gail Bekker; Glenda Gray; Veronica Ueckermann; Theresa Rossouw; Michael T. Boswell; Jinal N. Bhiman; Penny L. Moore; Alex Sigal; Ntobeko A. B. Ntusi; Wendy A. Burgers; Catherine Riou
<jats:title>Abstract</jats:title><jats:p>The SARS-CoV-2 Omicron variant (B.1.1.529) has multiple spike protein mutations<jats:sup>1,2</jats:sup> that contribute to viral escape from antibody neutralization<jats:sup>3–6</jats:sup> and reduce vaccine protection from infection<jats:sup>7,8</jats:sup>. The extent to which other components of the adaptive response such as T cells may still target Omicron and contribute to protection from severe outcomes is unknown. Here we assessed the ability of T cells to react to Omicron spike protein in participants who were vaccinated with Ad26.CoV2.S or BNT162b2, or unvaccinated convalescent COVID-19 patients (<jats:italic>n</jats:italic> = 70). Between 70% and 80% of the CD4<jats:sup>+</jats:sup> and CD8<jats:sup>+</jats:sup> T cell response to spike was maintained across study groups. Moreover, the magnitude of Omicron cross-reactive T cells was similar for Beta (B.1.351) and Delta (B.1.617.2) variants, despite Omicron harbouring considerably more mutations. In patients who were hospitalized with Omicron infections (<jats:italic>n</jats:italic> = 19), there were comparable T cell responses to ancestral spike, nucleocapsid and membrane proteins to those in patients hospitalized in previous waves dominated by the ancestral, Beta or Delta variants (<jats:italic>n</jats:italic> = 49). Thus, despite extensive mutations and reduced susceptibility to neutralizing antibodies of Omicron, the majority of T cell responses induced by vaccination or infection cross-recognize the variant. It remains to be determined whether well-preserved T cell immunity to Omicron contributes to protection from severe COVID-19 and is linked to early clinical observations from South Africa and elsewhere<jats:sup>9–12</jats:sup>.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 488-492
Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron
Jinyan Liu; Abishek Chandrashekar; Daniel Sellers; Julia Barrett; Catherine Jacob-Dolan; Michelle Lifton; Katherine McMahan; Michaela Sciacca; Haley VanWyk; Cindy Wu; Jingyou Yu; Ai-ris Y. Collier; Dan H. Barouch
<jats:title>Abstract</jats:title><jats:p>The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 spike protein<jats:sup>1</jats:sup>. Cellular immune responses, particularly CD8<jats:sup>+</jats:sup> T cell responses, probably contribute to protection against severe SARS-CoV-2 infection<jats:sup>2–6</jats:sup>. Here we show that cellular immunity induced by current vaccines against SARS-CoV-2 is highly conserved to the SARS-CoV-2 Omicron spike protein. Individuals who received the Ad26.COV2.S or BNT162b2 vaccines demonstrated durable spike-specific CD8<jats:sup>+</jats:sup> and CD4<jats:sup>+</jats:sup> T cell responses, which showed extensive cross-reactivity against both the Delta and the Omicron variants, including in central and effector memory cellular subpopulations. Median Omicron spike-specific CD8<jats:sup>+</jats:sup> T cell responses were 82–84% of the WA1/2020 spike-specific CD8<jats:sup>+</jats:sup> T cell responses. These data provide immunological context for the observation that current vaccines still show robust protection against severe disease with the SARS-CoV-2 Omicron variant despite the substantially reduced neutralizing antibody responses<jats:sup>7,8</jats:sup>.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 493-496
Establishment of fetomaternal tolerance through glycan-mediated BÂ cell suppression
G. Rizzuto; J. F. Brooks; S. T. Tuomivaara; T. I. McIntyre; S. Ma; D. Rideaux; J. Zikherman; S. J. Fisher; A. Erlebacher
Palabras clave: Multidisciplinary.
Pp. 497-502
Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria
Kazuki Saito; Hanna Kratzat; Annabelle Campbell; Robert Buschauer; A. Maxwell Burroughs; Otto Berninghausen; L. Aravind; Rachel Green; Roland Beckmann; Allen R. Buskirk
Palabras clave: Multidisciplinary.
Pp. 503-508
Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue
Federico Cerullo; Sebastian Filbeck; Pratik Rajendra Patil; Hao-Chih Hung; Haifei Xu; Julia Vornberger; Florian W. Hofer; Jaro Schmitt; Guenter Kramer; Bernd Bukau; Kay Hofmann; Stefan Pfeffer; Claudio A. P. Joazeiro
Palabras clave: Multidisciplinary.
Pp. 509-514
Discovery of a Ni2+-dependent guanidine hydrolase in bacteria
D. Funck; M. Sinn; J. R. Fleming; M. Stanoppi; J. Dietrich; R. López-Igual; O. Mayans; J. S. Hartig
Palabras clave: Multidisciplinary.
Pp. 515-521
Overcoming universal restrictions on metal selectivity by protein design
Tae Su Choi; F. Akif Tezcan
Palabras clave: Multidisciplinary.
Pp. 522-527