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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Ancient DNA and deep population structure in sub-Saharan African foragers
Mark Lipson; Elizabeth A. Sawchuk
; Jessica C. Thompson; Jonas Oppenheimer; Christian A. Tryon; Kathryn L. Ranhorn; Kathryn M. de Luna; Kendra A. Sirak; Iñigo Olalde; Stanley H. Ambrose; John W. Arthur; Kathryn J. W. Arthur; George Ayodo; Alex Bertacchi; Jessica I. Cerezo-Román; Brendan J. Culleton; Matthew C. Curtis; Jacob Davis; Agness O. Gidna; Annalys Hanson; Potiphar Kaliba; Maggie Katongo; Amandus Kwekason; Myra F. Laird; Jason Lewis; Audax Z. P. Mabulla; Fredrick Mapemba; Alan Morris; George Mudenda; Raphael Mwafulirwa; Daudi Mwangomba; Emmanuel Ndiema; Christine Ogola; Flora Schilt; Pamela R. Willoughby; David K. Wright; Andrew Zipkin; Ron Pinhasi; Douglas J. Kennett; Fredrick Kyalo Manthi; Nadin Rohland; Nick Patterson; David Reich; Mary E. Prendergast
<jats:title>Abstract</jats:title><jats:p>Multiple lines of genetic and archaeological evidence suggest that there were major demographic changes in the terminal Late Pleistocene epoch and early Holocene epoch of sub-Saharan Africa<jats:sup>1–4</jats:sup>. Inferences about this period are challenging to make because demographic shifts in the past 5,000 years have obscured the structures of more ancient populations<jats:sup>3,5</jats:sup>. Here we present genome-wide ancient DNA data for six individuals from eastern and south-central Africa spanning the past approximately 18,000 years (doubling the time depth of sub-Saharan African ancient DNA), increase the data quality for 15 previously published ancient individuals and analyse these alongside data from 13 other published ancient individuals. The ancestry of the individuals in our study area can be modelled as a geographically structured mixture of three highly divergent source populations, probably reflecting Pleistocene interactions around 80–20 thousand years ago, including deeply diverged eastern and southern African lineages, plus a previously unappreciated ubiquitous distribution of ancestry that occurs in highest proportion today in central African rainforest hunter-gatherers. Once established, this structure remained highly stable, with limited long-range gene flow. These results provide a new line of genetic evidence in support of hypotheses that have emerged from archaeological analyses but remain contested, suggesting increasing regionalization at the end of the Pleistocene epoch.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 290-296
Knowledge about others reduces one’s own sense of anonymity
Anuj K. Shah; Michael LaForest
Palabras clave: Multidisciplinary.
Pp. 297-301
Differential mechanisms underlie trace and delay conditioning in Drosophila
Dhruv Grover; Jen-Yung Chen; Jiayun Xie; Jinfang Li; Jean-Pierre Changeux; Ralph J. Greenspan
Palabras clave: Multidisciplinary.
Pp. 302-308
Molecular hallmarks of heterochronic parabiosis at single-cell resolution
Róbert Pálovics; Andreas Keller; Nicholas Schaum; Weilun Tan; Tobias Fehlmann; Michael Borja; Fabian Kern; Liana Bonanno; Kruti Calcuttawala; James Webber; Aaron McGeever; Nicole Almanzar; Jane Antony; Ankit S. Baghel; Isaac Bakerman; Ishita Bansal; Ben A. Barres; Philip A. Beachy; Daniela Berdnik; Biter Bilen; Douglas Brownfield; Corey Cain; Charles K. F. Chan; Michelle B. Chen; Michael F. Clarke; Stephanie D. Conley; Aaron Demers; Kubilay Demir; Antoine de Morree; Tessa Divita; Haley du Bois; Hamid Ebadi; F. Hernán Espinoza; Matt Fish; Qiang Gan; Benson M. George; Astrid Gillich; Rafael Gòmez-Sjöberg; Foad Green; Geraldine Genetiano; Xueying Gu; Gunsagar S. Gulati; Oliver Hahn; Michael Seamus Haney; Yan Hang; Lincoln Harris; Mu He; Shayan Hosseinzadeh; Albin Huang; Kerwyn Casey Huang; Tal Iram; Taichi Isobe; Feather Ives; Robert C. Jones; Kevin S. Kao; Guruswamy Karnam; Aaron M. Kershner; Nathalie Khoury; Seung K. Kim; Bernhard M. Kiss; William Kong; Mark A. Krasnow; Maya E. Kumar; Christin S. Kuo; Jonathan Lam; Davis P. Lee; Song E. Lee; Benoit Lehallier; Olivia Leventhal; Guang Li; Qingyun Li; Ling Liu; Annie Lo; Wan-Jin Lu; Maria F. Lugo-Fagundo; Anoop Manjunath; Andrew P. May; Ashley Maynard; Marina McKay; M. Windy McNerney; Bryan Merrill; Ross J. Metzger; Marco Mignardi; Dullei Min; Ahmad N. Nabhan; Katharine M. Ng; Patricia K. Nguyen; Joseph Noh; Roel Nusse; Rasika Patkar; Weng Chuan Peng; Lolita Penland; Katherine Pollard; Robert Puccinelli; Zhen Qi; Thomas A. Rando; Eric J. Rulifson; Joe M. Segal; Shaheen S. Sikandar; Rahul Sinha; Rene V. Sit; Justin Sonnenburg; Daniel Staehli; Krzysztof Szade; Michelle Tan; Cristina Tato; Krissie Tellez; Laughing Bear Torrez Dulgeroff; Kyle J. Travaglini; Carolina Tropini; Margaret Tsui; Lucas Waldburger; Bruce M. Wang; Linda J. van Weele; Kenneth Weinberg; Irving L. Weissman; Michael N. Wosczyna; Sean M. Wu; Jinyi Xiang; Soso Xue; Kevin A. Yamauchi; Andrew C. Yang; Lakshmi P. Yerra; Justin Youngyunpipatkul; Brian Yu; Fabio Zanini; Macy E. Zardeneta; Alexander Zee; Chunyu Zhao; Fan Zhang; Hui Zhang; Martin Jinye Zhang; Lu Zhou; James Zou; Jian Luo; Angela Oliveira Pisco; Jim Karkanias; Norma F. Neff; Spyros Darmanis; Stephen R. Quake; Tony Wyss-Coray;
Palabras clave: Multidisciplinary.
Pp. 309-314
The bacterial toxin colibactin triggers prophage induction
Justin E. Silpe; Joel W. H. Wong; Siân V. Owen; Michael Baym; Emily P. Balskus
<jats:title>Abstract</jats:title><jats:p>Colibactin is a chemically unstable small-molecule genotoxin that is produced by several different bacteria, including members of the human gut microbiome<jats:sup>1,2</jats:sup>. Although the biological activity of colibactin has been extensively investigated in mammalian systems<jats:sup>3</jats:sup>, little is known about its effects on other microorganisms. Here we show that colibactin targets bacteria that contain prophages, and induces lytic development through the bacterial SOS response. DNA, added exogenously, protects bacteria from colibactin, as does expressing a colibactin resistance protein (ClbS) in non-colibactin-producing cells. The prophage-inducing effects that we observe apply broadly across different phage–bacteria systems and in complex communities. Finally, we identify bacteria that have colibactin resistance genes but lack colibactin biosynthetic genes. Many of these bacteria are infected with predicted prophages, and we show that the expression of their ClbS homologues provides immunity from colibactin-triggered induction. Our study reveals a mechanism by which colibactin production could affect microbiomes and highlights a role for microbial natural products in influencing population-level events such as phage outbreaks.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 315-320
Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM
Tobias V. Lanz; R. Camille Brewer; Peggy P. Ho; Jae-Seung Moon; Kevin M. Jude; Daniel Fernandez; Ricardo A. Fernandes; Alejandro M. Gomez; Gabriel-Stefan Nadj; Christopher M. Bartley; Ryan D. Schubert; Isobel A. Hawes; Sara E. Vazquez; Manasi Iyer; J. Bradley Zuchero; Bianca Teegen; Jeffrey E. Dunn; Christopher B. Lock; Lucas B. Kipp; Victoria C. Cotham; Beatrix M. Ueberheide; Blake T. Aftab; Mark S. Anderson; Joseph L. DeRisi; Michael R. Wilson; Rachael J. M. Bashford-Rogers; Michael Platten; K. Christopher Garcia; Lawrence Steinman; William H. Robinson
Palabras clave: Multidisciplinary.
Pp. 321-327
A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells
Edward Seung; Zhen Xing; Lan Wu; Ercole Rao; Virna Cortez-Retamozo; Beatriz Ospina; Liqing Chen; Christian Beil; Zhili Song; Bailin Zhang; Mikhail Levit; Gejing Deng; Andrew Hebert; Patrick Kirby; Aiqun Li; Emma-Jane Poulton; Rita Vicente; Audrey Garrigou; Peter Piepenhagen; Greg Ulinski; Michele Sanicola-Nadel; Dinesh S. Bangari; Huawei Qiu; Lily Pao; Dmitri Wiederschain; Ronnie Wei; Zhi-yong Yang; Gary J. Nabel
Palabras clave: Multidisciplinary.
Pp. 328-334
Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers
Yoshihisa Kobayashi; Chhayheng Chhoeu; Jiaqi Li; Kristin S. Price; Lesli A. Kiedrowski; Jamie L. Hutchins; Aaron I. Hardin; Zihan Wei; Fangxin Hong; Magda Bahcall; Prafulla C. Gokhale; Pasi A. Jänne
Palabras clave: Multidisciplinary.
Pp. 335-342
Structural basis for mismatch surveillance by CRISPR–Cas9
Jack P. K. Bravo; Mu-Sen Liu; Grace N. Hibshman; Tyler L. Dangerfield; Kyungseok Jung; Ryan S. McCool; Kenneth A. Johnson; David W. Taylor
<jats:title>Abstract</jats:title><jats:p>CRISPR–Cas9 as a programmable genome editing tool is hindered by off-target DNA cleavage<jats:sup>1–4</jats:sup>, and the underlying mechanisms by which Cas9 recognizes mismatches are poorly understood<jats:sup>5–7</jats:sup>. Although Cas9 variants with greater discrimination against mismatches have been designed<jats:sup>8–10</jats:sup>, these suffer from substantially reduced rates of on-target DNA cleavage<jats:sup>5,11</jats:sup>. Here we used kinetics-guided cryo-electron microscopy to determine the structure of Cas9 at different stages of mismatch cleavage. We observed a distinct, linear conformation of the guide RNA–DNA duplex formed in the presence of mismatches, which prevents Cas9 activation. Although the canonical kinked guide RNA–DNA duplex conformation facilitates DNA cleavage, we observe that substrates that contain mismatches distal to the protospacer adjacent motif are stabilized by reorganization of a loop in the RuvC domain. Mutagenesis of mismatch-stabilizing residues reduces off-target DNA cleavage but maintains rapid on-target DNA cleavage. By targeting regions that are exclusively involved in mismatch tolerance, we provide a proof of concept for the design of next-generation high-fidelity Cas9 variants.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 343-347
Marching in the streets for climate-crisis action
Christine Ro
Palabras clave: Multidisciplinary.
Pp. 349-351