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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Moving bar of light evokes vectorial spatial selectivity in the immobile rat hippocampus
Chinmay S. Purandare; Shonali Dhingra; Rodrigo Rios; Cliff Vuong; Thuc To; Ayaka Hachisuka; Krishna Choudhary; Mayank R. Mehta
Palabras clave: Multidisciplinary.
Pp. 461-467
Sensory representation and detection mechanisms of gut osmolality change
Takako Ichiki; Tongtong Wang; Ann Kennedy; Allan-Hermann Pool; Haruka Ebisu; David J. Anderson; Yuki Oka
Palabras clave: Multidisciplinary.
Pp. 468-474
VLDLR and ApoER2 are receptors for multiple alphaviruses
Lars E. Clark; Sarah A. Clark; ChieYu Lin; Jianying Liu; Adrian Coscia; Katherine G. Nabel; Pan Yang; Dylan V. Neel; Hyo Lee; Vesna Brusic; Iryna Stryapunina; Kenneth S. Plante; Asim A. Ahmed; Flaminia Catteruccia; Tracy L. Young-Pearse; Isaac M. Chiu; Paula Montero Llopis; Scott C. Weaver; Jonathan Abraham
Palabras clave: Multidisciplinary.
Pp. 475-480
SARS-CoV-2 infection in free-ranging white-tailed deer
Vanessa L. Hale; Patricia M. Dennis; Dillon S. McBride; Jacqueline M. Nolting; Christopher Madden; Devra Huey; Margot Ehrlich; Jennifer Grieser; Jenessa Winston; Dusty Lombardi; Stormy Gibson; Linda Saif; Mary L. Killian; Kristina Lantz; Rachel M. Tell; Mia Torchetti; Suelee Robbe-Austerman; Martha I. Nelson; Seth A. Faith; Andrew S. Bowman
Palabras clave: Multidisciplinary.
Pp. 481-486
Evolution of enhanced innate immune evasion by SARS-CoV-2
Lucy G. Thorne; Mehdi Bouhaddou; Ann-Kathrin Reuschl; Lorena Zuliani-Alvarez; Ben Polacco; Adrian Pelin; Jyoti Batra; Matthew V. X. Whelan; Myra Hosmillo; Andrea Fossati; Roberta Ragazzini; Irwin Jungreis; Manisha Ummadi; Ajda Rojc; Jane Turner; Marie L. Bischof; Kirsten Obernier; Hannes Braberg; Margaret Soucheray; Alicia Richards; Kuei-Ho Chen; Bhavya Harjai; Danish Memon; Joseph Hiatt; Romel Rosales; Briana L. McGovern; Aminu Jahun; Jacqueline M. Fabius; Kris White; Ian G. Goodfellow; Yasu Takeuchi; Paola Bonfanti; Kevan Shokat; Natalia Jura; Klim Verba; Mahdad Noursadeghi; Pedro Beltrao; Manolis Kellis; Danielle L. Swaney; Adolfo García-Sastre; Clare Jolly; Greg J. Towers; Nevan J. Krogan
<jats:title>Abstract</jats:title><jats:p>The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance human-to-human transmission<jats:sup>1,2</jats:sup>. Although much effort has focused on the characterization of changes in the spike protein in variants of concern, mutations outside of spike are likely to contribute to adaptation. Here, using unbiased abundance proteomics, phosphoproteomics, RNA sequencing and viral replication assays, we show that isolates of the Alpha (B.1.1.7) variant<jats:sup>3</jats:sup> suppress innate immune responses in airway epithelial cells more effectively than first-wave isolates. We found that the Alpha variant has markedly increased subgenomic RNA and protein levels of the nucleocapsid protein (N), Orf9b and Orf6—all known innate immune antagonists. Expression of Orf9b alone suppressed the innate immune response through interaction with TOM70, a mitochondrial protein that is required for activation of the RNA-sensing adaptor MAVS. Moreover, the activity of Orf9b and its association with TOM70 was regulated by phosphorylation. We propose that more effective innate immune suppression, through enhanced expression of specific viral antagonist proteins, increases the likelihood of successful transmission of the Alpha variant, and may increase in vivo replication and duration of infection<jats:sup>4</jats:sup>. The importance of mutations outside the spike coding region in the adaptation of SARS-CoV-2 to humans is underscored by the observation that similar mutations exist in the N and Orf9b regulatory regions of the Delta and Omicron variants.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 487-495
Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
Wanyan Deng; Yang Bai; Fan Deng; Youdong Pan; Shenglin Mei; Zengzhang Zheng; Rui Min; Zeyu Wu; Wu Li; Rui Miao; Zhibin Zhang; Thomas S. Kupper; Judy Lieberman; Xing Liu
Palabras clave: Multidisciplinary.
Pp. 496-502
Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
J. Joseph Melenhorst; Gregory M. Chen; Meng Wang; David L. Porter; Changya Chen; McKensie A. Collins; Peng Gao; Shovik Bandyopadhyay; Hongxing Sun; Ziran Zhao; Stefan Lundh; Iulian Pruteanu-Malinici; Christopher L. Nobles; Sayantan Maji; Noelle V. Frey; Saar I. Gill; Lifeng Tian; Irina Kulikovskaya; Minnal Gupta; David E. Ambrose; Megan M. Davis; Joseph A. Fraietta; Jennifer L. Brogdon; Regina M. Young; Anne Chew; Bruce L. Levine; Donald L. Siegel; Cécile Alanio; E. John Wherry; Frederic D. Bushman; Simon F. Lacey; Kai Tan; Carl H. June
Palabras clave: Multidisciplinary.
Pp. 503-509
Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA
Erik N. Bergstrom; Jens Luebeck; Mia Petljak; Azhar Khandekar; Mark Barnes; Tongwu Zhang; Christopher D. Steele; Nischalan Pillay; Maria Teresa Landi; Vineet Bafna; Paul S. Mischel; Reuben S. Harris; Ludmil B. Alexandrov
<jats:title>Abstract</jats:title><jats:p>Clustered somatic mutations are common in cancer genomes and previous analyses reveal several types of clustered single-base substitutions, which include doublet- and multi-base substitutions<jats:sup>1–5</jats:sup>, diffuse hypermutation termed omikli<jats:sup>6</jats:sup>, and longer strand-coordinated events termed kataegis<jats:sup>3,7–9</jats:sup>. Here we provide a comprehensive characterization of clustered substitutions and clustered small insertions and deletions (indels) across 2,583 whole-genome-sequenced cancers from 30 types of cancer<jats:sup>10</jats:sup>. Clustered mutations were highly enriched in driver genes and associated with differential gene expression and changes in overall survival. Several distinct mutational processes gave rise to clustered indels, including signatures that were enriched in tobacco smokers and homologous-recombination-deficient cancers. Doublet-base substitutions were caused by at least 12 mutational processes, whereas most multi-base substitutions were generated by either tobacco smoking or exposure to ultraviolet light. Omikli events, which have previously been attributed to APOBEC3 activity<jats:sup>6</jats:sup>, accounted for a large proportion of clustered substitutions; however, only 16.2% of omikli matched APOBEC3 patterns. Kataegis was generated by multiple mutational processes, and 76.1% of all kataegic events exhibited mutational patterns that are associated with the activation-induced deaminase (AID) and APOBEC3 family of deaminases. Co-occurrence of APOBEC3 kataegis and extrachromosomal DNA (ecDNA), termed kyklonas (Greek for cyclone), was found in 31% of samples with ecDNA. Multiple distinct kyklonic events were observed on most mutated ecDNA. ecDNA containing known cancer genes exhibited both positive selection and kyklonic hypermutation. Our results reveal the diversity of clustered mutational processes in human cancer and the role of APOBEC3 in recurrently mutating and fuelling the evolution of ecDNA.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 510-517
Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias
Chun Hu; Carlos A. Leche; Anatoly Kiyatkin; Zhaolong Yu; Steven E. Stayrook; Kathryn M. Ferguson; Mark A. Lemmon
Palabras clave: Multidisciplinary.
Pp. 518-522
A backbone-centred energy function of neural networks for protein design
Bin Huang; Yang Xu; Xiuhong Hu; Yongrui Liu; Shanhui Liao; Jiahai Zhang; Chengdong Huang; Jingjun Hong; Quan Chen; Haiyan Liu
Palabras clave: Multidisciplinary.
Pp. 523-528