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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Collective durotaxis along a self-generated stiffness gradient in vivo
Adam Shellard
; Roberto Mayor
Palabras clave: Multidisciplinary.
Pp. 690-694
Unrepresentative big surveys significantly overestimated US vaccine uptake
Valerie C. Bradley; Shiro Kuriwaki; Michael Isakov; Dino Sejdinovic; Xiao-Li Meng; Seth Flaxman
Palabras clave: Multidisciplinary.
Pp. 695-700
Immunogenicity and efficacy of          heterologous ChAdOx1–BNT162b2 vaccination
Bruno Pozzetto; Vincent Legros; Sophia Djebali; Véronique Barateau; Nicolas Guibert; Marine Villard; Loïc Peyrot; Omran Allatif; Jean-Baptiste Fassier; Amélie Massardier-Pilonchéry; Karen Brengel-Pesce; Melyssa Yaugel-Novoa; Solène Denolly; Bertrand Boson; Thomas Bourlet; Antonin Bal; Martine Valette; Thibault Andrieu; Bruno Lina; Kahina Saker; Christelle Compagnon; Bouchra Mokdad; Constance d’Aubarede; Virginie Pitiot; Vanessa Escuret; Florence Morfin; Mary-Anne Trabaud; Margaux Prieux; Valérie Dubois; Laurence Josset; Soizic Daniel; François-Loïc Cosset; Stéphane Paul; Thierry Defrance; Jacqueline Marvel; Thierry Walzer; Sophie Trouillet-Assant;
Palabras clave: Multidisciplinary.
Pp. 701-706
Antigen-presenting innate lymphoid cells orchestrate neuroinflammation
John B. Grigg; Arthi Shanmugavadivu; Tommy Regen; Christopher N. Parkhurst; Anees Ahmed; Ann M. Joseph; Michael Mazzucco; Konrad Gronke; Andreas Diefenbach; Gerard Eberl; Timothy Vartanian; Ari Waisman; Gregory F. Sonnenberg
Palabras clave: Multidisciplinary.
Pp. 707-712
Gut microbiota modulates weight gain in mice after discontinued smoke exposure
Leviel Fluhr; Uria Mor; Aleksandra A. Kolodziejczyk; Mally Dori-Bachash; Avner Leshem; Shlomik Itav; Yotam Cohen; Jotham Suez; Niv Zmora; Claudia Moresi; Shahar Molina; Niv Ayalon; Rafael Valdés-Mas; Shanni Hornstein; Hodaya Karbi; Denise Kviatcovsky; Adi Livne; Aurelie Bukimer; Shimrit Eliyahu-Miller; Alona Metz; Alexander Brandis; Tevie Mehlman; Yael Kuperman; Michael Tsoory; Noa Stettner; Alon Harmelin; Hagit Shapiro; Eran Elinav
Palabras clave: Multidisciplinary.
Pp. 713-719
A hormone complex of FABP4 and nucleoside kinases regulates islet function
Kacey J. Prentice; Jani Saksi; Lauren T. Robertson; Grace Y. Lee; Karen E. Inouye; Kosei Eguchi; Alexandra Lee; Ozgur Cakici; Emily Otterbeck; Paulina Cedillo; Peter Achenbach; Anette-Gabriele Ziegler; Ediz S. Calay; Feyza Engin; Gökhan S. Hotamisligil
Palabras clave: Multidisciplinary.
Pp. 720-726
The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer
Yelena Y. Janjigian; Akihito Kawazoe; Patricio Yañez; Ning Li; Sara Lonardi; Oleksii Kolesnik; Olga Barajas; Yuxian Bai; Lin Shen; Yong Tang; Lucjan S. Wyrwicz; Jianming Xu; Kohei Shitara; Shukui Qin; Eric Van Cutsem; Josep Tabernero; Lie Li; Sukrut Shah; Pooja Bhagia; Hyun Cheol Chung
Palabras clave: Multidisciplinary.
Pp. 727-730
ecDNA hubs drive cooperative intermolecular oncogene expression
King L. Hung; Kathryn E. Yost; Liangqi Xie; Quanming Shi; Konstantin Helmsauer; Jens Luebeck; Robert Schöpflin; Joshua T. Lange; Rocío Chamorro González; Natasha E. Weiser; Celine Chen; Maria E. Valieva; Ivy Tsz-Lo Wong; Sihan Wu; Siavash R. Dehkordi; Connor V. Duffy; Katerina Kraft; Jun Tang; Julia A. Belk; John C. Rose; M. Ryan Corces; Jeffrey M. Granja; Rui Li; Utkrisht Rajkumar; Jordan Friedlein; Anindya Bagchi; Ansuman T. Satpathy; Robert Tjian; Stefan Mundlos; Vineet Bafna; Anton G. Henssen; Paul S. Mischel; Zhe Liu; Howard Y. Chang
Palabras clave: Multidisciplinary.
Pp. 731-736
Sex-specific chromatin remodelling safeguards transcription in germ cells
Tien-Chi Huang; Yi-Fang Wang; Eric Vazquez-Ferrer; Ina Theofel; Cristina E. Requena; Courtney W. Hanna; Gavin Kelsey; Petra Hajkova
Palabras clave: Multidisciplinary.
Pp. 737-742
A conserved mechanism for regulating replisome disassembly in eukaryotes
Michael Jenkyn-Bedford; Morgan L. Jones; Yasemin Baris; Karim P. M. Labib; Giuseppe Cannone; Joseph T. P. Yeeles; Tom D. Deegan
<jats:title>Abstract</jats:title><jats:p>Replisome disassembly is the final step of eukaryotic DNA replication and is triggered by ubiquitylation of the CDC45–MCM–GINS (CMG) replicative helicase<jats:sup>1–3</jats:sup>. Despite being driven by evolutionarily diverse E3 ubiquitin ligases in different eukaryotes (SCF<jats:sup>Dia2</jats:sup> in budding yeast<jats:sup>1</jats:sup>, CUL2<jats:sup>LRR1</jats:sup> in metazoa<jats:sup>4–7</jats:sup>), replisome disassembly is governed by a common regulatory principle, in which ubiquitylation of CMG is suppressed before replication termination, to prevent replication fork collapse. Recent evidence suggests that this suppression is mediated by replication fork DNA<jats:sup>8–10</jats:sup>. However, it is unknown how SCF<jats:sup>Dia2</jats:sup> and CUL2<jats:sup>LRR1</jats:sup> discriminate terminated from elongating replisomes, to selectively ubiquitylate CMG only after termination. Here we used cryo-electron microscopy to solve high-resolution structures of budding yeast and human replisome–E3 ligase assemblies. Our structures show that the leucine-rich repeat domains of Dia2 and LRR1 are structurally distinct, but bind to a common site on CMG, including the MCM3 and MCM5 zinc-finger domains. The LRR–MCM interaction is essential for replisome disassembly and, crucially, is occluded by the excluded DNA strand at replication forks, establishing the structural basis for the suppression of CMG ubiquitylation before termination. Our results elucidate a conserved mechanism for the regulation of replisome disassembly in eukaryotes, and reveal a previously unanticipated role for DNA in preserving replisome integrity.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 743-747