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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Mental health concerns during the COVID-19 pandemic as revealed by helpline calls
Marius Brülhart
; Valentin Klotzbücher; Rafael Lalive; Stephanie K. Reich
Palabras clave: Multidisciplinary.
Pp. 121-126
Cryptic transmission of SARS-CoV-2 and the first COVID-19 wave
Jessica T. Davis; Matteo Chinazzi; Nicola Perra; Kunpeng Mu; Ana Pastore y Piontti; Marco Ajelli; Natalie E. Dean; Corrado Gioannini; Maria Litvinova; Stefano Merler; Luca Rossi; Kaiyuan Sun; Xinyue Xiong; Ira M. Longini; M. Elizabeth Halloran; Cécile Viboud; Alessandro Vespignani
<jats:title>Abstract</jats:title><jats:p>Considerable uncertainty surrounds the timeline of introductions and onsets of local transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) globally<jats:sup>1–7</jats:sup>. Although a limited number of SARS-CoV-2 introductions were reported in January and February 2020 (refs.<jats:sup>8,9</jats:sup>), the narrowness of the initial testing criteria, combined with a slow growth in testing capacity and porous travel screening<jats:sup>10</jats:sup>, left many countries vulnerable to unmitigated, cryptic transmission. Here we use a global metapopulation epidemic model to provide a mechanistic understanding of the early dispersal of infections and the temporal windows of the introduction of SARS-CoV-2 and onset of local transmission in Europe and the USA. We find that community transmission of SARS-CoV-2 was likely to have been present in several areas of Europe and the USA by January 2020, and estimate that by early March, only 1 to 4 in 100 SARS-CoV-2 infections were detected by surveillance systems. The modelling results highlight international travel as the key driver of the introduction of SARS-CoV-2, with possible introductions and transmission events as early as December 2019 to January 2020. We find a heterogeneous geographic distribution of cumulative infection attack rates by 4 July 2020, ranging from 0.78% to 15.2% across US states and 0.19% to 13.2% in European countries. Our approach complements phylogenetic analyses and other surveillance approaches and provides insights that can be used to design innovative, model-driven surveillance systems that guide enhanced testing and response strategies.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 127-132
Independent infections of porcine deltacoronavirus among Haitian children
John A. Lednicky; Massimiliano S. Tagliamonte; Sarah K. White; Maha A. Elbadry; Md. Mahbubul Alam; Caroline J. Stephenson; Tania S. Bonny; Julia C. Loeb; Taina Telisma; Sonese Chavannes; David A. Ostrov; Carla Mavian; Valery Madsen Beau De Rochars; Marco Salemi; J. Glenn Morris
<jats:title>Abstract</jats:title><jats:p>Coronaviruses have caused three major epidemics since 2003, including the ongoing SARS-CoV-2 pandemic. In each case, the emergence of coronavirus in our species has been associated with zoonotic transmissions from animal reservoirs<jats:sup>1,2</jats:sup>, underscoring how prone such pathogens are to spill over and adapt to new species. Among the four recognized genera of the family <jats:italic>Coronaviridae</jats:italic>, human infections reported so far have been limited to alphacoronaviruses and betacoronaviruses<jats:sup>3–5</jats:sup>. Here we identify porcine deltacoronavirus strains in plasma samples of three Haitian children with acute undifferentiated febrile illness. Genomic and evolutionary analyses reveal that human infections were the result of at least two independent zoonoses of distinct viral lineages that acquired the same mutational signature in the genes encoding Nsp15 and the spike glycoprotein. In particular, structural analysis predicts that one of the changes in the spike S1 subunit, which contains the receptor-binding domain, may affect the flexibility of the protein and its binding to the host cell receptor. Our findings highlight the potential for evolutionary change and adaptation leading to human infections by coronaviruses outside of the previously recognized human-associated coronavirus groups, particularly in settings where there may be close human–animal contact.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 133-137
Self-guarding of MORC3 enables virulence factor-triggered immunity
Moritz M. Gaidt; Alyssa Morrow; Marian R. Fairgrieve; Jonathan P. Karr; Nir Yosef; Russell E. Vance
Palabras clave: Multidisciplinary.
Pp. 138-142
Structural basis of cytokine-mediated activation of ALK family receptors
Steven De Munck; Mathias Provost; Michiko Kurikawa; Ikuko Omori; Junko Mukohyama; Jan Felix; Yehudi Bloch; Omar Abdel-Wahab; J. Fernando Bazan; Akihide Yoshimi; Savvas N. Savvides
Palabras clave: Multidisciplinary.
Pp. 143-147
Structural basis for ligand reception by anaplastic lymphoma kinase
Tongqing Li; Steven E. Stayrook; Yuko Tsutsui; Jianan Zhang; Yueyue Wang; Hengyi Li; Andrew Proffitt; Stefan G. Krimmer; Mansoor Ahmed; Olivia Belliveau; Ian X. Walker; Krishna C. Mudumbi; Yoshihisa Suzuki; Irit Lax; Diego Alvarado; Mark A. Lemmon; Joseph Schlessinger; Daryl E. Klein
Palabras clave: Multidisciplinary.
Pp. 148-152
Mechanism for the activation of the anaplastic lymphoma kinase receptor
Andrey V. Reshetnyak; Paolo Rossi; Alexander G. Myasnikov; Munia Sowaileh; Jyotidarsini Mohanty; Amanda Nourse; Darcie J. Miller; Irit Lax; Joseph Schlessinger; Charalampos G. Kalodimos
Palabras clave: Multidisciplinary.
Pp. 153-157
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
Lee Mulderrig; Juan I. Garaycoechea; Zewen K. Tuong; Christopher L. Millington; Felix A. Dingler; John R. Ferdinand; Liam Gaul; John A. Tadross; Mark J. Arends; Stephen O’Rahilly; Gerry P. Crossan; Menna R. Clatworthy; Ketan J. Patel
Palabras clave: Multidisciplinary.
Pp. 158-163
Structure, function and pharmacology of human itch receptor complexes
Fan Yang; Lulu Guo; Yu Li; Guopeng Wang; Jia Wang; Chao Zhang; Guo-Xing Fang; Xu Chen; Lei Liu; Xu Yan; Qun Liu; Changxiu Qu; Yunfei Xu; Peng Xiao; Zhongliang Zhu; Zijian Li; Jiuyao Zhou; Xiao Yu; Ning Gao; Jin-Peng Sun
Palabras clave: Multidisciplinary.
Pp. 164-169
Structure, function and pharmacology of human itch GPCRs
Can Cao; Hye Jin Kang; Isha Singh; He Chen; Chengwei Zhang; Wenlei Ye; Byron W. Hayes; Jing Liu; Ryan H. Gumpper; Brian J. Bender; Samuel T. Slocum; Brian E. Krumm; Katherine Lansu; John D. McCorvy; Wesley K. Kroeze; Justin G. English; Jeffrey F. DiBerto; Reid H. J. Olsen; Xi-Ping Huang; Shicheng Zhang; Yongfeng Liu; Kuglae Kim; Joel Karpiak; Lily Y. Jan; Soman N. Abraham; Jian Jin; Brian K. Shoichet; Jonathan F. Fay; Bryan L. Roth
Palabras clave: Multidisciplinary.
Pp. 170-175